Online sample conditioning for portable breath analyzers

Autores
Prabhakar, Amlendu; Iglesias, Rodrigo Alejandro; Shan, Xiaonan; Xian, Xiaojun; Zhang, Lihua; Tsow, Francis; Forzani, Erica S.; Tao, Nongjian
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Various innovative chemical sensors have been developed in recent years to sense dangerous substances in air and trace biomarkers in breath. However, in order to solve real world problems, the sensors must be equipped with efficient sample conditioning that can, e.g., control the humidity, which is discussed much less in the literature. To meet the demand, a miniaturized mouthpiece was developed for personal breath analyzers. A key function of the mouthpiece is to condition the humidity in real breath samples without changing the analyte concentrations and introducing substantial backpressure, which is achieved with optimized packing of desiccant particles. Numerical simulations were carried out to determine the performance of the mouthpiece in terms of various controllable parameters, such as the size, density, and geometry of the packing. Mouthpieces with different configurations were built and tested, and the experimental data validated the simulation findings. A mouthpiece with optimized performance reducing relative humidity from 95% (27 000 ppmV) to 29% (8000 ppmV) whereas retaining 92% nitric oxide (50 ppbV to 46 ppbV) was built and integrated into a hand-held exhaled nitric oxide sensor, and the performance of exhaled nitric oxide measurement was in good agreement with the gold standard chemiluminescence technique. Acetone, carbon dioxide, oxygen, and ammonia samples were also measured after passing through the desiccant mouthpiece using commercial sensors to examine wide applicability of this breath conditioning approach. © 2012 American Chemical Society.
Fil: Prabhakar, Amlendu. Arizona State University; Estados Unidos
Fil: Iglesias, Rodrigo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Arizona State University; Estados Unidos
Fil: Shan, Xiaonan. Arizona State University; Estados Unidos
Fil: Xian, Xiaojun. Arizona State University; Estados Unidos
Fil: Zhang, Lihua. Arizona State University; Estados Unidos
Fil: Tsow, Francis. Arizona State University; Estados Unidos
Fil: Forzani, Erica S.. Arizona State University; Estados Unidos
Fil: Tao, Nongjian. Arizona State University; Estados Unidos
Materia
Chemical Sensor
Sample Preparation
Mouthpiece
Breath Analyzer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/62481
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Online sample conditioning for portable breath analyzersPrabhakar, AmlenduIglesias, Rodrigo AlejandroShan, XiaonanXian, XiaojunZhang, LihuaTsow, FrancisForzani, Erica S.Tao, NongjianChemical SensorSample PreparationMouthpieceBreath Analyzerhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Various innovative chemical sensors have been developed in recent years to sense dangerous substances in air and trace biomarkers in breath. However, in order to solve real world problems, the sensors must be equipped with efficient sample conditioning that can, e.g., control the humidity, which is discussed much less in the literature. To meet the demand, a miniaturized mouthpiece was developed for personal breath analyzers. A key function of the mouthpiece is to condition the humidity in real breath samples without changing the analyte concentrations and introducing substantial backpressure, which is achieved with optimized packing of desiccant particles. Numerical simulations were carried out to determine the performance of the mouthpiece in terms of various controllable parameters, such as the size, density, and geometry of the packing. Mouthpieces with different configurations were built and tested, and the experimental data validated the simulation findings. A mouthpiece with optimized performance reducing relative humidity from 95% (27 000 ppmV) to 29% (8000 ppmV) whereas retaining 92% nitric oxide (50 ppbV to 46 ppbV) was built and integrated into a hand-held exhaled nitric oxide sensor, and the performance of exhaled nitric oxide measurement was in good agreement with the gold standard chemiluminescence technique. Acetone, carbon dioxide, oxygen, and ammonia samples were also measured after passing through the desiccant mouthpiece using commercial sensors to examine wide applicability of this breath conditioning approach. © 2012 American Chemical Society.Fil: Prabhakar, Amlendu. Arizona State University; Estados UnidosFil: Iglesias, Rodrigo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Arizona State University; Estados UnidosFil: Shan, Xiaonan. Arizona State University; Estados UnidosFil: Xian, Xiaojun. Arizona State University; Estados UnidosFil: Zhang, Lihua. Arizona State University; Estados UnidosFil: Tsow, Francis. Arizona State University; Estados UnidosFil: Forzani, Erica S.. Arizona State University; Estados UnidosFil: Tao, Nongjian. Arizona State University; Estados UnidosAmerican Chemical Society2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/62481Prabhakar, Amlendu; Iglesias, Rodrigo Alejandro; Shan, Xiaonan; Xian, Xiaojun; Zhang, Lihua; et al.; Online sample conditioning for portable breath analyzers; American Chemical Society; Analytical Chemistry; 84; 16; 8-2012; 7172-71780003-2700CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/ac301542jinfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/ac301542jinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:04Zoai:ri.conicet.gov.ar:11336/62481instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:04.584CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Online sample conditioning for portable breath analyzers
title Online sample conditioning for portable breath analyzers
spellingShingle Online sample conditioning for portable breath analyzers
Prabhakar, Amlendu
Chemical Sensor
Sample Preparation
Mouthpiece
Breath Analyzer
title_short Online sample conditioning for portable breath analyzers
title_full Online sample conditioning for portable breath analyzers
title_fullStr Online sample conditioning for portable breath analyzers
title_full_unstemmed Online sample conditioning for portable breath analyzers
title_sort Online sample conditioning for portable breath analyzers
dc.creator.none.fl_str_mv Prabhakar, Amlendu
Iglesias, Rodrigo Alejandro
Shan, Xiaonan
Xian, Xiaojun
Zhang, Lihua
Tsow, Francis
Forzani, Erica S.
Tao, Nongjian
author Prabhakar, Amlendu
author_facet Prabhakar, Amlendu
Iglesias, Rodrigo Alejandro
Shan, Xiaonan
Xian, Xiaojun
Zhang, Lihua
Tsow, Francis
Forzani, Erica S.
Tao, Nongjian
author_role author
author2 Iglesias, Rodrigo Alejandro
Shan, Xiaonan
Xian, Xiaojun
Zhang, Lihua
Tsow, Francis
Forzani, Erica S.
Tao, Nongjian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chemical Sensor
Sample Preparation
Mouthpiece
Breath Analyzer
topic Chemical Sensor
Sample Preparation
Mouthpiece
Breath Analyzer
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Various innovative chemical sensors have been developed in recent years to sense dangerous substances in air and trace biomarkers in breath. However, in order to solve real world problems, the sensors must be equipped with efficient sample conditioning that can, e.g., control the humidity, which is discussed much less in the literature. To meet the demand, a miniaturized mouthpiece was developed for personal breath analyzers. A key function of the mouthpiece is to condition the humidity in real breath samples without changing the analyte concentrations and introducing substantial backpressure, which is achieved with optimized packing of desiccant particles. Numerical simulations were carried out to determine the performance of the mouthpiece in terms of various controllable parameters, such as the size, density, and geometry of the packing. Mouthpieces with different configurations were built and tested, and the experimental data validated the simulation findings. A mouthpiece with optimized performance reducing relative humidity from 95% (27 000 ppmV) to 29% (8000 ppmV) whereas retaining 92% nitric oxide (50 ppbV to 46 ppbV) was built and integrated into a hand-held exhaled nitric oxide sensor, and the performance of exhaled nitric oxide measurement was in good agreement with the gold standard chemiluminescence technique. Acetone, carbon dioxide, oxygen, and ammonia samples were also measured after passing through the desiccant mouthpiece using commercial sensors to examine wide applicability of this breath conditioning approach. © 2012 American Chemical Society.
Fil: Prabhakar, Amlendu. Arizona State University; Estados Unidos
Fil: Iglesias, Rodrigo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Arizona State University; Estados Unidos
Fil: Shan, Xiaonan. Arizona State University; Estados Unidos
Fil: Xian, Xiaojun. Arizona State University; Estados Unidos
Fil: Zhang, Lihua. Arizona State University; Estados Unidos
Fil: Tsow, Francis. Arizona State University; Estados Unidos
Fil: Forzani, Erica S.. Arizona State University; Estados Unidos
Fil: Tao, Nongjian. Arizona State University; Estados Unidos
description Various innovative chemical sensors have been developed in recent years to sense dangerous substances in air and trace biomarkers in breath. However, in order to solve real world problems, the sensors must be equipped with efficient sample conditioning that can, e.g., control the humidity, which is discussed much less in the literature. To meet the demand, a miniaturized mouthpiece was developed for personal breath analyzers. A key function of the mouthpiece is to condition the humidity in real breath samples without changing the analyte concentrations and introducing substantial backpressure, which is achieved with optimized packing of desiccant particles. Numerical simulations were carried out to determine the performance of the mouthpiece in terms of various controllable parameters, such as the size, density, and geometry of the packing. Mouthpieces with different configurations were built and tested, and the experimental data validated the simulation findings. A mouthpiece with optimized performance reducing relative humidity from 95% (27 000 ppmV) to 29% (8000 ppmV) whereas retaining 92% nitric oxide (50 ppbV to 46 ppbV) was built and integrated into a hand-held exhaled nitric oxide sensor, and the performance of exhaled nitric oxide measurement was in good agreement with the gold standard chemiluminescence technique. Acetone, carbon dioxide, oxygen, and ammonia samples were also measured after passing through the desiccant mouthpiece using commercial sensors to examine wide applicability of this breath conditioning approach. © 2012 American Chemical Society.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/62481
Prabhakar, Amlendu; Iglesias, Rodrigo Alejandro; Shan, Xiaonan; Xian, Xiaojun; Zhang, Lihua; et al.; Online sample conditioning for portable breath analyzers; American Chemical Society; Analytical Chemistry; 84; 16; 8-2012; 7172-7178
0003-2700
CONICET Digital
CONICET
url http://hdl.handle.net/11336/62481
identifier_str_mv Prabhakar, Amlendu; Iglesias, Rodrigo Alejandro; Shan, Xiaonan; Xian, Xiaojun; Zhang, Lihua; et al.; Online sample conditioning for portable breath analyzers; American Chemical Society; Analytical Chemistry; 84; 16; 8-2012; 7172-7178
0003-2700
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/ac301542j
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/ac301542j
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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