Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory

Autores
Nanfaro, Federico; Cabrera Kreiker, Ricardo Jorge; Bazzocchini, Vanesa Silvana; Laconi, Myrian; Yunes, Roberto Miguel Federico
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present paper we show for the first time that pregnenolone sulfate (Preg-S) impairs rats' memory for novel object recognition when injected in lateral septum (1.2 μM). The effect of Preg-S is clearly related to the moment the reagent is administered: if administered shortly after the training phase, or prior to the test phase of the experiment, there is no amnesic effect. It is only amnesic when administered 30 min before training. Accordingly, Preg-S does not appear to affect the storage of new memories or their retrieval but rather the acquisition itself. Based on the described afferences and efferences of lateral septum, we suggest a possible stimulatory effect of Preg-S regarding glutamate receptors and/or an inhibitory effect of GABAreceptors located in local interneurons or recurrent axon collaterals, both of which have been reported to exist in the aforementioned nucleus.
Fil: Nanfaro, Federico. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Bazzocchini, Vanesa Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad de Mendoza; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Laconi, Myrian. Universidad Nacional de Cuyo; Argentina
Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad de Mendoza; Argentina. Universidad Nacional de Cuyo; Argentina
Materia
Lateral Septum
Male Rats (Sprague-Dawley)
Memory
Neuroactive Steroids
Novel Object Recognition
Pregnenolone Sulfate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/82307
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/82307
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memoryNanfaro, FedericoCabrera Kreiker, Ricardo JorgeBazzocchini, Vanesa SilvanaLaconi, MyrianYunes, Roberto Miguel FedericoLateral SeptumMale Rats (Sprague-Dawley)MemoryNeuroactive SteroidsNovel Object RecognitionPregnenolone Sulfatehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In the present paper we show for the first time that pregnenolone sulfate (Preg-S) impairs rats' memory for novel object recognition when injected in lateral septum (1.2 μM). The effect of Preg-S is clearly related to the moment the reagent is administered: if administered shortly after the training phase, or prior to the test phase of the experiment, there is no amnesic effect. It is only amnesic when administered 30 min before training. Accordingly, Preg-S does not appear to affect the storage of new memories or their retrieval but rather the acquisition itself. Based on the described afferences and efferences of lateral septum, we suggest a possible stimulatory effect of Preg-S regarding glutamate receptors and/or an inhibitory effect of GABAreceptors located in local interneurons or recurrent axon collaterals, both of which have been reported to exist in the aforementioned nucleus.Fil: Nanfaro, Federico. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cabrera Kreiker, Ricardo Jorge. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Bazzocchini, Vanesa Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad de Mendoza; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Laconi, Myrian. Universidad Nacional de Cuyo; ArgentinaFil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad de Mendoza; Argentina. Universidad Nacional de Cuyo; ArgentinaPolish Acad Sciences Inst Pharmacology2009-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/82307Nanfaro, Federico; Cabrera Kreiker, Ricardo Jorge; Bazzocchini, Vanesa Silvana; Laconi, Myrian; Yunes, Roberto Miguel Federico; Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory; Polish Acad Sciences Inst Pharmacology; Pharmacological Reports; 62; 2; 10-2009; 265-2721734-1140CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S1734-1140(10)70265-6info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1734114010702656info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:22:44Zoai:ri.conicet.gov.ar:11336/82307instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:22:44.241CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
title Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
spellingShingle Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
Nanfaro, Federico
Lateral Septum
Male Rats (Sprague-Dawley)
Memory
Neuroactive Steroids
Novel Object Recognition
Pregnenolone Sulfate
title_short Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
title_full Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
title_fullStr Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
title_full_unstemmed Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
title_sort Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory
dc.creator.none.fl_str_mv Nanfaro, Federico
Cabrera Kreiker, Ricardo Jorge
Bazzocchini, Vanesa Silvana
Laconi, Myrian
Yunes, Roberto Miguel Federico
author Nanfaro, Federico
author_facet Nanfaro, Federico
Cabrera Kreiker, Ricardo Jorge
Bazzocchini, Vanesa Silvana
Laconi, Myrian
Yunes, Roberto Miguel Federico
author_role author
author2 Cabrera Kreiker, Ricardo Jorge
Bazzocchini, Vanesa Silvana
Laconi, Myrian
Yunes, Roberto Miguel Federico
author2_role author
author
author
author
dc.subject.none.fl_str_mv Lateral Septum
Male Rats (Sprague-Dawley)
Memory
Neuroactive Steroids
Novel Object Recognition
Pregnenolone Sulfate
topic Lateral Septum
Male Rats (Sprague-Dawley)
Memory
Neuroactive Steroids
Novel Object Recognition
Pregnenolone Sulfate
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the present paper we show for the first time that pregnenolone sulfate (Preg-S) impairs rats' memory for novel object recognition when injected in lateral septum (1.2 μM). The effect of Preg-S is clearly related to the moment the reagent is administered: if administered shortly after the training phase, or prior to the test phase of the experiment, there is no amnesic effect. It is only amnesic when administered 30 min before training. Accordingly, Preg-S does not appear to affect the storage of new memories or their retrieval but rather the acquisition itself. Based on the described afferences and efferences of lateral septum, we suggest a possible stimulatory effect of Preg-S regarding glutamate receptors and/or an inhibitory effect of GABAreceptors located in local interneurons or recurrent axon collaterals, both of which have been reported to exist in the aforementioned nucleus.
Fil: Nanfaro, Federico. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Bazzocchini, Vanesa Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad de Mendoza; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Laconi, Myrian. Universidad Nacional de Cuyo; Argentina
Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad de Mendoza; Argentina. Universidad Nacional de Cuyo; Argentina
description In the present paper we show for the first time that pregnenolone sulfate (Preg-S) impairs rats' memory for novel object recognition when injected in lateral septum (1.2 μM). The effect of Preg-S is clearly related to the moment the reagent is administered: if administered shortly after the training phase, or prior to the test phase of the experiment, there is no amnesic effect. It is only amnesic when administered 30 min before training. Accordingly, Preg-S does not appear to affect the storage of new memories or their retrieval but rather the acquisition itself. Based on the described afferences and efferences of lateral septum, we suggest a possible stimulatory effect of Preg-S regarding glutamate receptors and/or an inhibitory effect of GABAreceptors located in local interneurons or recurrent axon collaterals, both of which have been reported to exist in the aforementioned nucleus.
publishDate 2009
dc.date.none.fl_str_mv 2009-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/82307
Nanfaro, Federico; Cabrera Kreiker, Ricardo Jorge; Bazzocchini, Vanesa Silvana; Laconi, Myrian; Yunes, Roberto Miguel Federico; Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory; Polish Acad Sciences Inst Pharmacology; Pharmacological Reports; 62; 2; 10-2009; 265-272
1734-1140
CONICET Digital
CONICET
url http://hdl.handle.net/11336/82307
identifier_str_mv Nanfaro, Federico; Cabrera Kreiker, Ricardo Jorge; Bazzocchini, Vanesa Silvana; Laconi, Myrian; Yunes, Roberto Miguel Federico; Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory; Polish Acad Sciences Inst Pharmacology; Pharmacological Reports; 62; 2; 10-2009; 265-272
1734-1140
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/S1734-1140(10)70265-6
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1734114010702656
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
application/pdf
dc.publisher.none.fl_str_mv Polish Acad Sciences Inst Pharmacology
publisher.none.fl_str_mv Polish Acad Sciences Inst Pharmacology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981252266721280
score 12.48226

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