A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor

Autores
Municoy, Sofia; Bellino, Martin Gonzalo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Controlling the functions that arise in biomolecular nanostructures is a major challenge in biotechnology developments. Liposomes have been used to encapsulate a wide variety of enzymes, but the emergent properties of systems in which enzymatic activity is controlled by surrounding liposomes have not been explored. Here, we report an assembly to actuate the reactivity of ureases through the change of the liposome permeability by means of temperature control. Using this approach, externally controlled enzyme inhibition and activation are successfully demonstrated. Furthermore, deposited on a sacrificial mesoporous thin film, this biosystem controllably rebuilds its surface to generate a 3D silica shell, which provides an additional demonstration to the proposed principle.
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Bellino, Martin Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Materia
Liposome
Nanocapsule
Enzymes
Biomineralization
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/83227
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactorMunicoy, SofiaBellino, Martin GonzaloLiposomeNanocapsuleEnzymesBiomineralizationhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Controlling the functions that arise in biomolecular nanostructures is a major challenge in biotechnology developments. Liposomes have been used to encapsulate a wide variety of enzymes, but the emergent properties of systems in which enzymatic activity is controlled by surrounding liposomes have not been explored. Here, we report an assembly to actuate the reactivity of ureases through the change of the liposome permeability by means of temperature control. Using this approach, externally controlled enzyme inhibition and activation are successfully demonstrated. Furthermore, deposited on a sacrificial mesoporous thin film, this biosystem controllably rebuilds its surface to generate a 3D silica shell, which provides an additional demonstration to the proposed principle.Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Bellino, Martin Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaRoyal Society of Chemistry2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/83227Municoy, Sofia; Bellino, Martin Gonzalo; A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor; Royal Society of Chemistry; RSC Advances; 7; 1; 1-2017; 67-702046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2017/ra/c6ra26676binfo:eu-repo/semantics/altIdentifier/doi/10.1039/c6ra26676binfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:46:00Zoai:ri.conicet.gov.ar:11336/83227instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:46:01.1CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
title A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
spellingShingle A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
Municoy, Sofia
Liposome
Nanocapsule
Enzymes
Biomineralization
title_short A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
title_full A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
title_fullStr A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
title_full_unstemmed A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
title_sort A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor
dc.creator.none.fl_str_mv Municoy, Sofia
Bellino, Martin Gonzalo
author Municoy, Sofia
author_facet Municoy, Sofia
Bellino, Martin Gonzalo
author_role author
author2 Bellino, Martin Gonzalo
author2_role author
dc.subject.none.fl_str_mv Liposome
Nanocapsule
Enzymes
Biomineralization
topic Liposome
Nanocapsule
Enzymes
Biomineralization
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Controlling the functions that arise in biomolecular nanostructures is a major challenge in biotechnology developments. Liposomes have been used to encapsulate a wide variety of enzymes, but the emergent properties of systems in which enzymatic activity is controlled by surrounding liposomes have not been explored. Here, we report an assembly to actuate the reactivity of ureases through the change of the liposome permeability by means of temperature control. Using this approach, externally controlled enzyme inhibition and activation are successfully demonstrated. Furthermore, deposited on a sacrificial mesoporous thin film, this biosystem controllably rebuilds its surface to generate a 3D silica shell, which provides an additional demonstration to the proposed principle.
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Bellino, Martin Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
description Controlling the functions that arise in biomolecular nanostructures is a major challenge in biotechnology developments. Liposomes have been used to encapsulate a wide variety of enzymes, but the emergent properties of systems in which enzymatic activity is controlled by surrounding liposomes have not been explored. Here, we report an assembly to actuate the reactivity of ureases through the change of the liposome permeability by means of temperature control. Using this approach, externally controlled enzyme inhibition and activation are successfully demonstrated. Furthermore, deposited on a sacrificial mesoporous thin film, this biosystem controllably rebuilds its surface to generate a 3D silica shell, which provides an additional demonstration to the proposed principle.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/83227
Municoy, Sofia; Bellino, Martin Gonzalo; A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor; Royal Society of Chemistry; RSC Advances; 7; 1; 1-2017; 67-70
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/83227
identifier_str_mv Municoy, Sofia; Bellino, Martin Gonzalo; A liposome-actuated enzyme system and its capability as a self-biomineralized silica nanoreactor; Royal Society of Chemistry; RSC Advances; 7; 1; 1-2017; 67-70
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2017/ra/c6ra26676b
info:eu-repo/semantics/altIdentifier/doi/10.1039/c6ra26676b
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082971378909184
score 13.22299

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