Recent Advances on Nanotechnology Applications to Cancer Drug Therapy

Autores
Bellera, Carolina Leticia; Gantner, Melisa Edith; Ruiz, María Esperanza; Talevi, Alan
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
One of the greatest challenges in cancer drug therapy is to maximize the effectiveness of the active ingredient while reducing its systemic adverse effects. Conventional (non-targeted) systemic drug therapy is characterized by unspecific distribution of the anticancer drugs: both healthy and affected tissues are thus exposed to the chemotherapeutic agent, giving raise to off-target side-effects. Besides, a number of widely-used chemoterapeutic agents present unfavorable physicochemical properties, such as low solubility or low stability issues, limiting their available routes of administration and therapeutic applications. Nano-delivery systems seem as promising solutions to these issues. They can be used for targeted-drug release, diagnostic imaging and therapy monitoring. Nanosystems allow the formulation of drug delivery systems with tailored properties (e.g. solubility, biodegradability, release kinetics and distribution) that provide means to improve cancer patients? quality of life by lowering the administered dose and, incidentally, the cost of clinical treatments. This article overviews the main features of different nanovehicles (linear and non-linear polymeric nanosystems, lipid-based systems, inorganic nanoparticles) and presents a selection of reports on applications of such systems to cancer therapy published between 2011 and 2013.
Fil: Bellera, Carolina Leticia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gantner, Melisa Edith. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ruiz, María Esperanza. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biologicas; Argentina
Fil: Talevi, Alan. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Anticancer Drug Therapy
Dendrimers
Inorganic Nanoparticles
Liposomes
Nanocapsules
Nanogels
Nanospheres
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9628
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Recent Advances on Nanotechnology Applications to Cancer Drug TherapyBellera, Carolina LeticiaGantner, Melisa EdithRuiz, María EsperanzaTalevi, AlanAnticancer Drug TherapyDendrimersInorganic NanoparticlesLiposomesNanocapsulesNanogelsNanosphereshttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2One of the greatest challenges in cancer drug therapy is to maximize the effectiveness of the active ingredient while reducing its systemic adverse effects. Conventional (non-targeted) systemic drug therapy is characterized by unspecific distribution of the anticancer drugs: both healthy and affected tissues are thus exposed to the chemotherapeutic agent, giving raise to off-target side-effects. Besides, a number of widely-used chemoterapeutic agents present unfavorable physicochemical properties, such as low solubility or low stability issues, limiting their available routes of administration and therapeutic applications. Nano-delivery systems seem as promising solutions to these issues. They can be used for targeted-drug release, diagnostic imaging and therapy monitoring. Nanosystems allow the formulation of drug delivery systems with tailored properties (e.g. solubility, biodegradability, release kinetics and distribution) that provide means to improve cancer patients? quality of life by lowering the administered dose and, incidentally, the cost of clinical treatments. This article overviews the main features of different nanovehicles (linear and non-linear polymeric nanosystems, lipid-based systems, inorganic nanoparticles) and presents a selection of reports on applications of such systems to cancer therapy published between 2011 and 2013.Fil: Bellera, Carolina Leticia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gantner, Melisa Edith. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ruiz, María Esperanza. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biologicas; ArgentinaFil: Talevi, Alan. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaLifescience Global2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9628Bellera, Carolina Leticia; Gantner, Melisa Edith; Ruiz, María Esperanza; Talevi, Alan; Recent Advances on Nanotechnology Applications to Cancer Drug Therapy; Lifescience Global; Journal of Cancer Research Updates; 2; 3; 7-2013; 151-1851929-2260enginfo:eu-repo/semantics/altIdentifier/url/http://www.lifescienceglobal.com/home/cart?view=product&id=658info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:49Zoai:ri.conicet.gov.ar:11336/9628instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:49.678CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
title Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
spellingShingle Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
Bellera, Carolina Leticia
Anticancer Drug Therapy
Dendrimers
Inorganic Nanoparticles
Liposomes
Nanocapsules
Nanogels
Nanospheres
title_short Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
title_full Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
title_fullStr Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
title_full_unstemmed Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
title_sort Recent Advances on Nanotechnology Applications to Cancer Drug Therapy
dc.creator.none.fl_str_mv Bellera, Carolina Leticia
Gantner, Melisa Edith
Ruiz, María Esperanza
Talevi, Alan
author Bellera, Carolina Leticia
author_facet Bellera, Carolina Leticia
Gantner, Melisa Edith
Ruiz, María Esperanza
Talevi, Alan
author_role author
author2 Gantner, Melisa Edith
Ruiz, María Esperanza
Talevi, Alan
author2_role author
author
author
dc.subject.none.fl_str_mv Anticancer Drug Therapy
Dendrimers
Inorganic Nanoparticles
Liposomes
Nanocapsules
Nanogels
Nanospheres
topic Anticancer Drug Therapy
Dendrimers
Inorganic Nanoparticles
Liposomes
Nanocapsules
Nanogels
Nanospheres
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv One of the greatest challenges in cancer drug therapy is to maximize the effectiveness of the active ingredient while reducing its systemic adverse effects. Conventional (non-targeted) systemic drug therapy is characterized by unspecific distribution of the anticancer drugs: both healthy and affected tissues are thus exposed to the chemotherapeutic agent, giving raise to off-target side-effects. Besides, a number of widely-used chemoterapeutic agents present unfavorable physicochemical properties, such as low solubility or low stability issues, limiting their available routes of administration and therapeutic applications. Nano-delivery systems seem as promising solutions to these issues. They can be used for targeted-drug release, diagnostic imaging and therapy monitoring. Nanosystems allow the formulation of drug delivery systems with tailored properties (e.g. solubility, biodegradability, release kinetics and distribution) that provide means to improve cancer patients? quality of life by lowering the administered dose and, incidentally, the cost of clinical treatments. This article overviews the main features of different nanovehicles (linear and non-linear polymeric nanosystems, lipid-based systems, inorganic nanoparticles) and presents a selection of reports on applications of such systems to cancer therapy published between 2011 and 2013.
Fil: Bellera, Carolina Leticia. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gantner, Melisa Edith. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ruiz, María Esperanza. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biologicas; Argentina
Fil: Talevi, Alan. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description One of the greatest challenges in cancer drug therapy is to maximize the effectiveness of the active ingredient while reducing its systemic adverse effects. Conventional (non-targeted) systemic drug therapy is characterized by unspecific distribution of the anticancer drugs: both healthy and affected tissues are thus exposed to the chemotherapeutic agent, giving raise to off-target side-effects. Besides, a number of widely-used chemoterapeutic agents present unfavorable physicochemical properties, such as low solubility or low stability issues, limiting their available routes of administration and therapeutic applications. Nano-delivery systems seem as promising solutions to these issues. They can be used for targeted-drug release, diagnostic imaging and therapy monitoring. Nanosystems allow the formulation of drug delivery systems with tailored properties (e.g. solubility, biodegradability, release kinetics and distribution) that provide means to improve cancer patients? quality of life by lowering the administered dose and, incidentally, the cost of clinical treatments. This article overviews the main features of different nanovehicles (linear and non-linear polymeric nanosystems, lipid-based systems, inorganic nanoparticles) and presents a selection of reports on applications of such systems to cancer therapy published between 2011 and 2013.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9628
Bellera, Carolina Leticia; Gantner, Melisa Edith; Ruiz, María Esperanza; Talevi, Alan; Recent Advances on Nanotechnology Applications to Cancer Drug Therapy; Lifescience Global; Journal of Cancer Research Updates; 2; 3; 7-2013; 151-185
1929-2260
url http://hdl.handle.net/11336/9628
identifier_str_mv Bellera, Carolina Leticia; Gantner, Melisa Edith; Ruiz, María Esperanza; Talevi, Alan; Recent Advances on Nanotechnology Applications to Cancer Drug Therapy; Lifescience Global; Journal of Cancer Research Updates; 2; 3; 7-2013; 151-185
1929-2260
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.lifescienceglobal.com/home/cart?view=product&id=658
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lifescience Global
publisher.none.fl_str_mv Lifescience Global
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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