Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities

Autores
Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria; Solano, Godofredo; Zacchino, Susana Alicia Stella; Gupta, Mahabir P.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
Fil: Tamayo Castillo, Giselle. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Vásquez, Victor. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Ríos, Maria Isabel. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Solano, Godofredo. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gupta, Mahabir P.. Universidad de Panama; Panamá
Materia
Godmania Aesculifolia
Lapachol
Chavicol Diglycoside
Bignoniaceae
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21815
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal ActivitiesTamayo Castillo, GiselleVásquez, VictorRíos, Maria IsabelRodriguez, María VictoriaSolano, GodofredoZacchino, Susana Alicia StellaGupta, Mahabir P.Godmania AesculifoliaLapacholChavicol DiglycosideBignoniaceaehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.Fil: Tamayo Castillo, Giselle. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa RicaFil: Vásquez, Victor. Instituto Nacional de Biodiversidad; Costa RicaFil: Ríos, Maria Isabel. Instituto Nacional de Biodiversidad; Costa RicaFil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Solano, Godofredo. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa RicaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gupta, Mahabir P.. Universidad de Panama; PanamáGeorg Thieme Verlag Kg2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21815Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria; Solano, Godofredo; et al.; Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities; Georg Thieme Verlag Kg; Planta Medica; 79; 18; 2-2013; 1749-17550032-0943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1055/s-0033-1351025info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1351025info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:48Zoai:ri.conicet.gov.ar:11336/21815instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:49.27CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
title Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
spellingShingle Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
Tamayo Castillo, Giselle
Godmania Aesculifolia
Lapachol
Chavicol Diglycoside
Bignoniaceae
title_short Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
title_full Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
title_fullStr Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
title_full_unstemmed Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
title_sort Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
dc.creator.none.fl_str_mv Tamayo Castillo, Giselle
Vásquez, Victor
Ríos, Maria Isabel
Rodriguez, María Victoria
Solano, Godofredo
Zacchino, Susana Alicia Stella
Gupta, Mahabir P.
author Tamayo Castillo, Giselle
author_facet Tamayo Castillo, Giselle
Vásquez, Victor
Ríos, Maria Isabel
Rodriguez, María Victoria
Solano, Godofredo
Zacchino, Susana Alicia Stella
Gupta, Mahabir P.
author_role author
author2 Vásquez, Victor
Ríos, Maria Isabel
Rodriguez, María Victoria
Solano, Godofredo
Zacchino, Susana Alicia Stella
Gupta, Mahabir P.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Godmania Aesculifolia
Lapachol
Chavicol Diglycoside
Bignoniaceae
topic Godmania Aesculifolia
Lapachol
Chavicol Diglycoside
Bignoniaceae
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
Fil: Tamayo Castillo, Giselle. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Vásquez, Victor. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Ríos, Maria Isabel. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Solano, Godofredo. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa Rica
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gupta, Mahabir P.. Universidad de Panama; Panamá
description From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21815
Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria; Solano, Godofredo; et al.; Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities; Georg Thieme Verlag Kg; Planta Medica; 79; 18; 2-2013; 1749-1755
0032-0943
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21815
identifier_str_mv Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria; Solano, Godofredo; et al.; Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities; Georg Thieme Verlag Kg; Planta Medica; 79; 18; 2-2013; 1749-1755
0032-0943
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0033-1351025
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1351025
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613319292354560
score 13.070432

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