Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform

Autores
Conde, Alvaro José; Battalla, Milena; Cerda, Maria Belen; Mykhaylyk, Olga; Plank, Christian; Podhajcer, Osvaldo Luis; Cabaleiro, Juan Martin; Madrid, Rossana Elena; Policastro, Lucia Laura
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We present a low-cost, portable microfluidic platform that uses laminated polymethylmethacrylate chips, peristaltic micropumps and LEGO® Mindstorms components for the generation of magnetoliposomes that does not require extrusion steps. Mixtures of lipids reconstituted in ethanol and an aqueous phase were injected independently in order to generate a combination of laminar flows in such a way that we could effectively achieve four hydrodynamic focused nanovesicle generation streams. Monodisperse magnetoliposomes with characteristics comparable to those obtained by traditional methods have been obtained. The magnetoliposomes are responsive to external magnetic field gradients, a result that suggests that the nanovesicles can be used in research and applications in nanomedicine.
Fil: Conde, Alvaro José. Universidad Nacional de Tucuman. Facultad de Cs.exactas y Tecnologia. Departamento de Bioingenieria. Laboratorio de Medios E Interfases; Argentina
Fil: Battalla, Milena. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; Argentina
Fil: Cerda, Maria Belen. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; Argentina
Fil: Mykhaylyk, Olga. Technische Universität München. Institute of Experimental Oncology and Therapy Research; Alemania
Fil: Plank, Christian. Technische Universität München. Institute of Experimental Oncology and Therapy Research; Alemania
Fil: Podhajcer, Osvaldo Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Cabaleiro, Juan Martin. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Ingenieria Mecanica. Laboratorio de Fluidodinamica; Argentina
Fil: Madrid, Rossana Elena. Universidad Nacional de Tucuman. Facultad de Cs.exactas y Tecnologia. Departamento de Bioingenieria. Laboratorio de Medios E Interfases; Argentina
Fil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; Argentina
Materia
Microfluidics
Magnetoliposomes
Nanovesicles
Methacrylate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8733
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platformConde, Alvaro JoséBattalla, MilenaCerda, Maria BelenMykhaylyk, OlgaPlank, ChristianPodhajcer, Osvaldo LuisCabaleiro, Juan MartinMadrid, Rossana ElenaPolicastro, Lucia LauraMicrofluidicsMagnetoliposomesNanovesiclesMethacrylatehttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2We present a low-cost, portable microfluidic platform that uses laminated polymethylmethacrylate chips, peristaltic micropumps and LEGO® Mindstorms components for the generation of magnetoliposomes that does not require extrusion steps. Mixtures of lipids reconstituted in ethanol and an aqueous phase were injected independently in order to generate a combination of laminar flows in such a way that we could effectively achieve four hydrodynamic focused nanovesicle generation streams. Monodisperse magnetoliposomes with characteristics comparable to those obtained by traditional methods have been obtained. The magnetoliposomes are responsive to external magnetic field gradients, a result that suggests that the nanovesicles can be used in research and applications in nanomedicine.Fil: Conde, Alvaro José. Universidad Nacional de Tucuman. Facultad de Cs.exactas y Tecnologia. Departamento de Bioingenieria. Laboratorio de Medios E Interfases; ArgentinaFil: Battalla, Milena. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; ArgentinaFil: Cerda, Maria Belen. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; ArgentinaFil: Mykhaylyk, Olga. Technische Universität München. Institute of Experimental Oncology and Therapy Research; AlemaniaFil: Plank, Christian. Technische Universität München. Institute of Experimental Oncology and Therapy Research; AlemaniaFil: Podhajcer, Osvaldo Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Cabaleiro, Juan Martin. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Ingenieria Mecanica. Laboratorio de Fluidodinamica; ArgentinaFil: Madrid, Rossana Elena. Universidad Nacional de Tucuman. Facultad de Cs.exactas y Tecnologia. Departamento de Bioingenieria. Laboratorio de Medios E Interfases; ArgentinaFil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; ArgentinaRoyal Society Of Chemistry2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8733Conde, Alvaro José; Battalla, Milena; Cerda, Maria Belen; Mykhaylyk, Olga; Plank, Christian; et al.; Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform; Royal Society Of Chemistry; Lab On A Chip; 14; 23; 9-2014; 4506-45121473-0197enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/LC/C4LC00839A#!divAbstractinfo:eu-repo/semantics/altIdentifier/doi/0.1039/c4lc00839ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:48:06Zoai:ri.conicet.gov.ar:11336/8733instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:48:06.832CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
title Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
spellingShingle Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
Conde, Alvaro José
Microfluidics
Magnetoliposomes
Nanovesicles
Methacrylate
title_short Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
title_full Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
title_fullStr Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
title_full_unstemmed Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
title_sort Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform
dc.creator.none.fl_str_mv Conde, Alvaro José
Battalla, Milena
Cerda, Maria Belen
Mykhaylyk, Olga
Plank, Christian
Podhajcer, Osvaldo Luis
Cabaleiro, Juan Martin
Madrid, Rossana Elena
Policastro, Lucia Laura
author Conde, Alvaro José
author_facet Conde, Alvaro José
Battalla, Milena
Cerda, Maria Belen
Mykhaylyk, Olga
Plank, Christian
Podhajcer, Osvaldo Luis
Cabaleiro, Juan Martin
Madrid, Rossana Elena
Policastro, Lucia Laura
author_role author
author2 Battalla, Milena
Cerda, Maria Belen
Mykhaylyk, Olga
Plank, Christian
Podhajcer, Osvaldo Luis
Cabaleiro, Juan Martin
Madrid, Rossana Elena
Policastro, Lucia Laura
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Microfluidics
Magnetoliposomes
Nanovesicles
Methacrylate
topic Microfluidics
Magnetoliposomes
Nanovesicles
Methacrylate
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv We present a low-cost, portable microfluidic platform that uses laminated polymethylmethacrylate chips, peristaltic micropumps and LEGO® Mindstorms components for the generation of magnetoliposomes that does not require extrusion steps. Mixtures of lipids reconstituted in ethanol and an aqueous phase were injected independently in order to generate a combination of laminar flows in such a way that we could effectively achieve four hydrodynamic focused nanovesicle generation streams. Monodisperse magnetoliposomes with characteristics comparable to those obtained by traditional methods have been obtained. The magnetoliposomes are responsive to external magnetic field gradients, a result that suggests that the nanovesicles can be used in research and applications in nanomedicine.
Fil: Conde, Alvaro José. Universidad Nacional de Tucuman. Facultad de Cs.exactas y Tecnologia. Departamento de Bioingenieria. Laboratorio de Medios E Interfases; Argentina
Fil: Battalla, Milena. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; Argentina
Fil: Cerda, Maria Belen. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; Argentina
Fil: Mykhaylyk, Olga. Technische Universität München. Institute of Experimental Oncology and Therapy Research; Alemania
Fil: Plank, Christian. Technische Universität München. Institute of Experimental Oncology and Therapy Research; Alemania
Fil: Podhajcer, Osvaldo Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Cabaleiro, Juan Martin. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Ingenieria Mecanica. Laboratorio de Fluidodinamica; Argentina
Fil: Madrid, Rossana Elena. Universidad Nacional de Tucuman. Facultad de Cs.exactas y Tecnologia. Departamento de Bioingenieria. Laboratorio de Medios E Interfases; Argentina
Fil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica. Gerencia Quimica. CAC; Argentina
description We present a low-cost, portable microfluidic platform that uses laminated polymethylmethacrylate chips, peristaltic micropumps and LEGO® Mindstorms components for the generation of magnetoliposomes that does not require extrusion steps. Mixtures of lipids reconstituted in ethanol and an aqueous phase were injected independently in order to generate a combination of laminar flows in such a way that we could effectively achieve four hydrodynamic focused nanovesicle generation streams. Monodisperse magnetoliposomes with characteristics comparable to those obtained by traditional methods have been obtained. The magnetoliposomes are responsive to external magnetic field gradients, a result that suggests that the nanovesicles can be used in research and applications in nanomedicine.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8733
Conde, Alvaro José; Battalla, Milena; Cerda, Maria Belen; Mykhaylyk, Olga; Plank, Christian; et al.; Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform; Royal Society Of Chemistry; Lab On A Chip; 14; 23; 9-2014; 4506-4512
1473-0197
url http://hdl.handle.net/11336/8733
identifier_str_mv Conde, Alvaro José; Battalla, Milena; Cerda, Maria Belen; Mykhaylyk, Olga; Plank, Christian; et al.; Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform; Royal Society Of Chemistry; Lab On A Chip; 14; 23; 9-2014; 4506-4512
1473-0197
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/LC/C4LC00839A#!divAbstract
info:eu-repo/semantics/altIdentifier/doi/0.1039/c4lc00839a
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society Of Chemistry
publisher.none.fl_str_mv Royal Society Of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847426492335652864
score 13.10058

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