A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery

Autores
Alcaina Hernando, Marta; Malvacio, Ivana; Ferraboschi, Ilaria; Huck Iriart, Cristián; Bianchera, Annalisa; Sala, Santi; Pedersen, Jan Skov; Ferrer Tasies, Lidia; Pescina, Silvia; Sissa, Cristina; Ventosa, Nora; Córdoba, Alba
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The finding of new vesicular systems is a challenging process that depends on different factors such as the components used, the interactions between them or the dispersant media. Our objective was to develop a new vesicular delivery system formed by self-assembly of β-Sitosterol (Sit), Lauryl Glucoside (LGL) and Lauryl Glucose Carboxylate (LGC) molecules, all plant-based, biodegradable and biocompatible components. Nanovesicles (NVs) with different molar ratios of Sit, LGL and LGC were prepared using a single step method named DELOS, and characterized by dynamic light scattering, cryo-electron microscopy and small-angle X-ray scattering. Antioxidant compound α-tocopherol (TCP) was integrated in the NVs showing their potential to nanoformulate hydrophobic payloads. Finally, in vitro biocompatibility assays with reconstructed human epidermis and ex vivo skin retention studies using multiphoton microscopy and NVs labelled with Nile Red (NR) were carried out. As a result of this work, a new platform of NVs has been obtained by the self-assembly of Sit, LGL and LGC, obtaining vesicular systems with tunable physicochemical properties in terms of size (130 – 220 nm), surface charge ((-70) – (-40) mV) and lamellarity (unilamellar and multilamellar vesicles), when the carbon chain of the alkyl polyglucoside was >12. The vesicles could efficiently integrate TCP, proving their potential role as delivery systems and maintaining its antioxidant activity after loading. Finally, they also showed biocompatibility with the skin and improved the permeability of the poorly water-soluble molecule NR in terms of time and depth through the epidermis. Overall, the results of this work point to the successful development of an attractive platform based on stable and homogeneous nanovesicles composed of plant-derived ingredients for topical delivery.
Fil: Alcaina Hernando, Marta. Nanomol Technologies S.l.; España. Institut de Ciència de Materials de Barcelona; España
Fil: Malvacio, Ivana. Nanomol Technologies S.l.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferraboschi, Ilaria. Università di Parma; Italia
Fil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina. ALBA Synchrotron Light Source; España
Fil: Bianchera, Annalisa. Universita Degli Studi Di Parma. Departamento de Alimentos y Drogas; Italia
Fil: Sala, Santi. Nanomol Technologies S.l.; España
Fil: Pedersen, Jan Skov. University Aarhus; Dinamarca
Fil: Ferrer Tasies, Lidia. Nanomol Technologies S.l.; España
Fil: Pescina, Silvia. Universita Degli Studi Di Parma. Departamento de Alimentos y Drogas; Italia
Fil: Sissa, Cristina. Università di Parma; Italia
Fil: Ventosa, Nora. Instituto de Salud Carlos Iii (isciii); . Institut de Ciència de Materials de Barcelona; España
Fil: Córdoba, Alba. Nanomol Technologies S.l.; España
Materia
Delivery system
Nanovesicle
Biocompatible
Plant based
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266915
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/266915
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical deliveryAlcaina Hernando, MartaMalvacio, IvanaFerraboschi, IlariaHuck Iriart, CristiánBianchera, AnnalisaSala, SantiPedersen, Jan SkovFerrer Tasies, LidiaPescina, SilviaSissa, CristinaVentosa, NoraCórdoba, AlbaDelivery systemNanovesicleBiocompatiblePlant basedhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The finding of new vesicular systems is a challenging process that depends on different factors such as the components used, the interactions between them or the dispersant media. Our objective was to develop a new vesicular delivery system formed by self-assembly of β-Sitosterol (Sit), Lauryl Glucoside (LGL) and Lauryl Glucose Carboxylate (LGC) molecules, all plant-based, biodegradable and biocompatible components. Nanovesicles (NVs) with different molar ratios of Sit, LGL and LGC were prepared using a single step method named DELOS, and characterized by dynamic light scattering, cryo-electron microscopy and small-angle X-ray scattering. Antioxidant compound α-tocopherol (TCP) was integrated in the NVs showing their potential to nanoformulate hydrophobic payloads. Finally, in vitro biocompatibility assays with reconstructed human epidermis and ex vivo skin retention studies using multiphoton microscopy and NVs labelled with Nile Red (NR) were carried out. As a result of this work, a new platform of NVs has been obtained by the self-assembly of Sit, LGL and LGC, obtaining vesicular systems with tunable physicochemical properties in terms of size (130 – 220 nm), surface charge ((-70) – (-40) mV) and lamellarity (unilamellar and multilamellar vesicles), when the carbon chain of the alkyl polyglucoside was >12. The vesicles could efficiently integrate TCP, proving their potential role as delivery systems and maintaining its antioxidant activity after loading. Finally, they also showed biocompatibility with the skin and improved the permeability of the poorly water-soluble molecule NR in terms of time and depth through the epidermis. Overall, the results of this work point to the successful development of an attractive platform based on stable and homogeneous nanovesicles composed of plant-derived ingredients for topical delivery.Fil: Alcaina Hernando, Marta. Nanomol Technologies S.l.; España. Institut de Ciència de Materials de Barcelona; EspañaFil: Malvacio, Ivana. Nanomol Technologies S.l.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferraboschi, Ilaria. Università di Parma; ItaliaFil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina. ALBA Synchrotron Light Source; EspañaFil: Bianchera, Annalisa. Universita Degli Studi Di Parma. Departamento de Alimentos y Drogas; ItaliaFil: Sala, Santi. Nanomol Technologies S.l.; EspañaFil: Pedersen, Jan Skov. University Aarhus; DinamarcaFil: Ferrer Tasies, Lidia. Nanomol Technologies S.l.; EspañaFil: Pescina, Silvia. Universita Degli Studi Di Parma. Departamento de Alimentos y Drogas; ItaliaFil: Sissa, Cristina. Università di Parma; ItaliaFil: Ventosa, Nora. Instituto de Salud Carlos Iii (isciii); . Institut de Ciència de Materials de Barcelona; EspañaFil: Córdoba, Alba. Nanomol Technologies S.l.; EspañaElsevier2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266915Alcaina Hernando, Marta; Malvacio, Ivana; Ferraboschi, Ilaria; Huck Iriart, Cristián; Bianchera, Annalisa; et al.; A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery; Elsevier; Applied Materials Today; 41; 102467; 12-2024; 1-132352-9407CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2352940724004128info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apmt.2024.102467info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:42:20Zoai:ri.conicet.gov.ar:11336/266915instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:42:20.715CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
title A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
spellingShingle A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
Alcaina Hernando, Marta
Delivery system
Nanovesicle
Biocompatible
Plant based
title_short A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
title_full A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
title_fullStr A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
title_full_unstemmed A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
title_sort A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
dc.creator.none.fl_str_mv Alcaina Hernando, Marta
Malvacio, Ivana
Ferraboschi, Ilaria
Huck Iriart, Cristián
Bianchera, Annalisa
Sala, Santi
Pedersen, Jan Skov
Ferrer Tasies, Lidia
Pescina, Silvia
Sissa, Cristina
Ventosa, Nora
Córdoba, Alba
author Alcaina Hernando, Marta
author_facet Alcaina Hernando, Marta
Malvacio, Ivana
Ferraboschi, Ilaria
Huck Iriart, Cristián
Bianchera, Annalisa
Sala, Santi
Pedersen, Jan Skov
Ferrer Tasies, Lidia
Pescina, Silvia
Sissa, Cristina
Ventosa, Nora
Córdoba, Alba
author_role author
author2 Malvacio, Ivana
Ferraboschi, Ilaria
Huck Iriart, Cristián
Bianchera, Annalisa
Sala, Santi
Pedersen, Jan Skov
Ferrer Tasies, Lidia
Pescina, Silvia
Sissa, Cristina
Ventosa, Nora
Córdoba, Alba
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Delivery system
Nanovesicle
Biocompatible
Plant based
topic Delivery system
Nanovesicle
Biocompatible
Plant based
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The finding of new vesicular systems is a challenging process that depends on different factors such as the components used, the interactions between them or the dispersant media. Our objective was to develop a new vesicular delivery system formed by self-assembly of β-Sitosterol (Sit), Lauryl Glucoside (LGL) and Lauryl Glucose Carboxylate (LGC) molecules, all plant-based, biodegradable and biocompatible components. Nanovesicles (NVs) with different molar ratios of Sit, LGL and LGC were prepared using a single step method named DELOS, and characterized by dynamic light scattering, cryo-electron microscopy and small-angle X-ray scattering. Antioxidant compound α-tocopherol (TCP) was integrated in the NVs showing their potential to nanoformulate hydrophobic payloads. Finally, in vitro biocompatibility assays with reconstructed human epidermis and ex vivo skin retention studies using multiphoton microscopy and NVs labelled with Nile Red (NR) were carried out. As a result of this work, a new platform of NVs has been obtained by the self-assembly of Sit, LGL and LGC, obtaining vesicular systems with tunable physicochemical properties in terms of size (130 – 220 nm), surface charge ((-70) – (-40) mV) and lamellarity (unilamellar and multilamellar vesicles), when the carbon chain of the alkyl polyglucoside was >12. The vesicles could efficiently integrate TCP, proving their potential role as delivery systems and maintaining its antioxidant activity after loading. Finally, they also showed biocompatibility with the skin and improved the permeability of the poorly water-soluble molecule NR in terms of time and depth through the epidermis. Overall, the results of this work point to the successful development of an attractive platform based on stable and homogeneous nanovesicles composed of plant-derived ingredients for topical delivery.
Fil: Alcaina Hernando, Marta. Nanomol Technologies S.l.; España. Institut de Ciència de Materials de Barcelona; España
Fil: Malvacio, Ivana. Nanomol Technologies S.l.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferraboschi, Ilaria. Università di Parma; Italia
Fil: Huck Iriart, Cristián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina. ALBA Synchrotron Light Source; España
Fil: Bianchera, Annalisa. Universita Degli Studi Di Parma. Departamento de Alimentos y Drogas; Italia
Fil: Sala, Santi. Nanomol Technologies S.l.; España
Fil: Pedersen, Jan Skov. University Aarhus; Dinamarca
Fil: Ferrer Tasies, Lidia. Nanomol Technologies S.l.; España
Fil: Pescina, Silvia. Universita Degli Studi Di Parma. Departamento de Alimentos y Drogas; Italia
Fil: Sissa, Cristina. Università di Parma; Italia
Fil: Ventosa, Nora. Instituto de Salud Carlos Iii (isciii); . Institut de Ciència de Materials de Barcelona; España
Fil: Córdoba, Alba. Nanomol Technologies S.l.; España
description The finding of new vesicular systems is a challenging process that depends on different factors such as the components used, the interactions between them or the dispersant media. Our objective was to develop a new vesicular delivery system formed by self-assembly of β-Sitosterol (Sit), Lauryl Glucoside (LGL) and Lauryl Glucose Carboxylate (LGC) molecules, all plant-based, biodegradable and biocompatible components. Nanovesicles (NVs) with different molar ratios of Sit, LGL and LGC were prepared using a single step method named DELOS, and characterized by dynamic light scattering, cryo-electron microscopy and small-angle X-ray scattering. Antioxidant compound α-tocopherol (TCP) was integrated in the NVs showing their potential to nanoformulate hydrophobic payloads. Finally, in vitro biocompatibility assays with reconstructed human epidermis and ex vivo skin retention studies using multiphoton microscopy and NVs labelled with Nile Red (NR) were carried out. As a result of this work, a new platform of NVs has been obtained by the self-assembly of Sit, LGL and LGC, obtaining vesicular systems with tunable physicochemical properties in terms of size (130 – 220 nm), surface charge ((-70) – (-40) mV) and lamellarity (unilamellar and multilamellar vesicles), when the carbon chain of the alkyl polyglucoside was >12. The vesicles could efficiently integrate TCP, proving their potential role as delivery systems and maintaining its antioxidant activity after loading. Finally, they also showed biocompatibility with the skin and improved the permeability of the poorly water-soluble molecule NR in terms of time and depth through the epidermis. Overall, the results of this work point to the successful development of an attractive platform based on stable and homogeneous nanovesicles composed of plant-derived ingredients for topical delivery.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266915
Alcaina Hernando, Marta; Malvacio, Ivana; Ferraboschi, Ilaria; Huck Iriart, Cristián; Bianchera, Annalisa; et al.; A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery; Elsevier; Applied Materials Today; 41; 102467; 12-2024; 1-13
2352-9407
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266915
identifier_str_mv Alcaina Hernando, Marta; Malvacio, Ivana; Ferraboschi, Ilaria; Huck Iriart, Cristián; Bianchera, Annalisa; et al.; A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery; Elsevier; Applied Materials Today; 41; 102467; 12-2024; 1-13
2352-9407
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2352940724004128
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apmt.2024.102467
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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