Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease

Autores
Castro, Eduardo Fidel; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Fogel, Fernando Adrián; Franci, Rodolfo; Denzoin, Laura; Ortega, Irma
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.
Fil: Castro, Eduardo Fidel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fogel, Fernando Adrián. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Franci, Rodolfo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Denzoin, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Ortega, Irma. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Materia
CATS
FENOPROFEN
CHIRAL INVERSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/106498
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/106498
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic diseaseCastro, Eduardo FidelSoraci, Alejandro LuisTapia, Maria OfeliaFogel, Fernando AdriánFranci, RodolfoDenzoin, LauraOrtega, IrmaCATSFENOPROFENCHIRAL INVERSIONhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.Fil: Castro, Eduardo Fidel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; ArgentinaFil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; ArgentinaFil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fogel, Fernando Adrián. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; ArgentinaFil: Franci, Rodolfo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; ArgentinaFil: Denzoin, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; ArgentinaFil: Ortega, Irma. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; ArgentinaMedwell Online2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106498Castro, Eduardo Fidel; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Fogel, Fernando Adrián; Franci, Rodolfo; et al.; Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease; Medwell Online; Journal of Animal and Veterinary Advances; 5; 3; 12-2006; 176-1831680-55931993-601XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://medwelljournals.com/abstract/?doi=javaa.2006.176.183info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:01Zoai:ri.conicet.gov.ar:11336/106498instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:01.865CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
title Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
spellingShingle Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
Castro, Eduardo Fidel
CATS
FENOPROFEN
CHIRAL INVERSION
title_short Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
title_full Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
title_fullStr Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
title_full_unstemmed Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
title_sort Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease
dc.creator.none.fl_str_mv Castro, Eduardo Fidel
Soraci, Alejandro Luis
Tapia, Maria Ofelia
Fogel, Fernando Adrián
Franci, Rodolfo
Denzoin, Laura
Ortega, Irma
author Castro, Eduardo Fidel
author_facet Castro, Eduardo Fidel
Soraci, Alejandro Luis
Tapia, Maria Ofelia
Fogel, Fernando Adrián
Franci, Rodolfo
Denzoin, Laura
Ortega, Irma
author_role author
author2 Soraci, Alejandro Luis
Tapia, Maria Ofelia
Fogel, Fernando Adrián
Franci, Rodolfo
Denzoin, Laura
Ortega, Irma
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CATS
FENOPROFEN
CHIRAL INVERSION
topic CATS
FENOPROFEN
CHIRAL INVERSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.
Fil: Castro, Eduardo Fidel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fogel, Fernando Adrián. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Franci, Rodolfo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Denzoin, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
Fil: Ortega, Irma. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
description The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/106498
Castro, Eduardo Fidel; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Fogel, Fernando Adrián; Franci, Rodolfo; et al.; Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease; Medwell Online; Journal of Animal and Veterinary Advances; 5; 3; 12-2006; 176-183
1680-5593
1993-601X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/106498
identifier_str_mv Castro, Eduardo Fidel; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Fogel, Fernando Adrián; Franci, Rodolfo; et al.; Chiral inversion of R-(-) Fenoprofen enantiomer in cats with toxic hepatic disease; Medwell Online; Journal of Animal and Veterinary Advances; 5; 3; 12-2006; 176-183
1680-5593
1993-601X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://medwelljournals.com/abstract/?doi=javaa.2006.176.183
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Medwell Online
publisher.none.fl_str_mv Medwell Online
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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