Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies

Autores
Agotegaray, Mariela Alejandra; Boeris, M. A.; Diez, Alejandra Silvina; Prat, María Rosa; Quinzani, Oscar Valentín
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2]2H 2O (1) [dmf = N,N'-dimethylformamide; L = 4,4'-bipyridine (2), pyrazine (3), and 2,5-dimethylpyrazine (4)]. The new complexes were characterized by chemical analysis, spectroscopic, and thermogravimetric techniques. Antioxidant properties of 1-4 were evaluated for superoxide-dismutase-mimic activity employing the XTT method. Complex 2 presented the highest antioxidant activity (IC50 = 0.260 mol L-1). Anti-inflammatory properties of 2 were evaluated employing carrageenan-induced paw edema in mice, revealing that the Fenoprofen-copper(II) complex containing 4,4'-bipyridine does not present enhanced anti-inflammatory activity compared to the uncomplexed parent drug Fenoprofen calcium salt. © 2011 Taylor & Francis.
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Boeris, M. A.. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Diez, Alejandra Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Prat, María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Quinzani, Oscar Valentín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
Anti-Inflammatory
Copper
Fenoprofen
Sod
Spectroscopy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64702
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studiesAgotegaray, Mariela AlejandraBoeris, M. A.Diez, Alejandra SilvinaPrat, María RosaQuinzani, Oscar ValentínAnti-InflammatoryCopperFenoprofenSodSpectroscopyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2]2H 2O (1) [dmf = N,N'-dimethylformamide; L = 4,4'-bipyridine (2), pyrazine (3), and 2,5-dimethylpyrazine (4)]. The new complexes were characterized by chemical analysis, spectroscopic, and thermogravimetric techniques. Antioxidant properties of 1-4 were evaluated for superoxide-dismutase-mimic activity employing the XTT method. Complex 2 presented the highest antioxidant activity (IC50 = 0.260 mol L-1). Anti-inflammatory properties of 2 were evaluated employing carrageenan-induced paw edema in mice, revealing that the Fenoprofen-copper(II) complex containing 4,4'-bipyridine does not present enhanced anti-inflammatory activity compared to the uncomplexed parent drug Fenoprofen calcium salt. © 2011 Taylor & Francis.Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Boeris, M. A.. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; ArgentinaFil: Diez, Alejandra Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Prat, María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Quinzani, Oscar Valentín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaTaylor & Francis Ltd2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/64702Agotegaray, Mariela Alejandra; Boeris, M. A.; Diez, Alejandra Silvina; Prat, María Rosa; Quinzani, Oscar Valentín; Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies; Taylor & Francis Ltd; Journal of Coordination Chemistry; 64; 13; 7-2011; 2246-22610095-8972CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/00958972.2011.594508info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00958972.2011.594508info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:33:17Zoai:ri.conicet.gov.ar:11336/64702instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:33:17.619CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
title Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
spellingShingle Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
Agotegaray, Mariela Alejandra
Anti-Inflammatory
Copper
Fenoprofen
Sod
Spectroscopy
title_short Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
title_full Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
title_fullStr Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
title_full_unstemmed Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
title_sort Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies
dc.creator.none.fl_str_mv Agotegaray, Mariela Alejandra
Boeris, M. A.
Diez, Alejandra Silvina
Prat, María Rosa
Quinzani, Oscar Valentín
author Agotegaray, Mariela Alejandra
author_facet Agotegaray, Mariela Alejandra
Boeris, M. A.
Diez, Alejandra Silvina
Prat, María Rosa
Quinzani, Oscar Valentín
author_role author
author2 Boeris, M. A.
Diez, Alejandra Silvina
Prat, María Rosa
Quinzani, Oscar Valentín
author2_role author
author
author
author
dc.subject.none.fl_str_mv Anti-Inflammatory
Copper
Fenoprofen
Sod
Spectroscopy
topic Anti-Inflammatory
Copper
Fenoprofen
Sod
Spectroscopy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2]2H 2O (1) [dmf = N,N'-dimethylformamide; L = 4,4'-bipyridine (2), pyrazine (3), and 2,5-dimethylpyrazine (4)]. The new complexes were characterized by chemical analysis, spectroscopic, and thermogravimetric techniques. Antioxidant properties of 1-4 were evaluated for superoxide-dismutase-mimic activity employing the XTT method. Complex 2 presented the highest antioxidant activity (IC50 = 0.260 mol L-1). Anti-inflammatory properties of 2 were evaluated employing carrageenan-induced paw edema in mice, revealing that the Fenoprofen-copper(II) complex containing 4,4'-bipyridine does not present enhanced anti-inflammatory activity compared to the uncomplexed parent drug Fenoprofen calcium salt. © 2011 Taylor & Francis.
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Boeris, M. A.. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Diez, Alejandra Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Prat, María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Quinzani, Oscar Valentín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description Three dinuclear copper(II) complexes with the anti-inflammatory drug Fenoprofen [Hfen, 2-(3-phenoxyphenyl)propionic acid] and nitrogen donors of general formula [Cu2(fen)4(L)]n were prepared from [Cu2(fen)4(dmf)2]2H 2O (1) [dmf = N,N'-dimethylformamide; L = 4,4'-bipyridine (2), pyrazine (3), and 2,5-dimethylpyrazine (4)]. The new complexes were characterized by chemical analysis, spectroscopic, and thermogravimetric techniques. Antioxidant properties of 1-4 were evaluated for superoxide-dismutase-mimic activity employing the XTT method. Complex 2 presented the highest antioxidant activity (IC50 = 0.260 mol L-1). Anti-inflammatory properties of 2 were evaluated employing carrageenan-induced paw edema in mice, revealing that the Fenoprofen-copper(II) complex containing 4,4'-bipyridine does not present enhanced anti-inflammatory activity compared to the uncomplexed parent drug Fenoprofen calcium salt. © 2011 Taylor & Francis.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64702
Agotegaray, Mariela Alejandra; Boeris, M. A.; Diez, Alejandra Silvina; Prat, María Rosa; Quinzani, Oscar Valentín; Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies; Taylor & Francis Ltd; Journal of Coordination Chemistry; 64; 13; 7-2011; 2246-2261
0095-8972
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64702
identifier_str_mv Agotegaray, Mariela Alejandra; Boeris, M. A.; Diez, Alejandra Silvina; Prat, María Rosa; Quinzani, Oscar Valentín; Dinuclear copper(II) complexes of Fenoprofen: Synthesis, spectroscopic, thermal, and SOD-mimic activity studies; Taylor & Francis Ltd; Journal of Coordination Chemistry; 64; 13; 7-2011; 2246-2261
0095-8972
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/00958972.2011.594508
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00958972.2011.594508
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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