Effects of Nutritional Deficiency of Boron on the Bones of the Appendicular Skeleton of Mice

• Autores: Gorustovich Alonso, Alejandro Adrian; Nielsen, Forrest H.
• Año de publicación: 2018
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Boron; Cortical bone; Osteocyte lacunae; Histomorphometry; Biomechanical properties
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Scientific evidence has shown the nutritional importance of boron (B) in the remodeling and repair of cancellous bone tissue. However, the effects of the nutritional deficiency of B on the cortical bone tissue of the appendicular skeleton have not yet been described. Thus, a study was performed to histomorphometrically evaluate the density of osteocyte lacunae of cortical bone of mouse femora under conditions of nutritional deficiency of B and to analyze the effects of the deficiency on the biomechanical properties of mouse tibiae. Weaning, 21-day-old male Swiss mice were assigned to the following two groups: Controls (B+; n = 10) and Experimental (B-; n = 10). Control mice were fed a basal diet containing 3 mg B/Kg, whereas experimental mice were fed a B-deficient diet containing 0.07 mg B/Kg for 9 weeks. The histological and histomorphometric evaluations of the mice fed a B-deficient diet showed a decrease in the density of osteocyte lacunae in the femoral cortical bone tissue and the evaluation of biomechanical properties showed lower bone rigidity in the tibia.
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Fil: Gorustovich Alonso, Alejandro Adrian. Universidad Católica de Salta; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina
Fil: Nielsen, Forrest H.. No especifíca;