More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
- Autores
- Presman, Diego Martin; Hager, Gordon L.
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer.
Fil: Presman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Institutes of Health; Estados Unidos
Fil: Hager, Gordon L.. National Institutes of Health; Estados Unidos - Materia
-
DIMER
DNA BINDING
GLUCOCORTICOID RECEPTOR
MONOMER
STEROID RECEPTORS
TETRAMER - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
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- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/64876
Ver los metadatos del registro completo
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More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?Presman, Diego MartinHager, Gordon L.DIMERDNA BINDINGGLUCOCORTICOID RECEPTORMONOMERSTEROID RECEPTORSTETRAMERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer.Fil: Presman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Institutes of Health; Estados UnidosFil: Hager, Gordon L.. National Institutes of Health; Estados UnidosTaylor2017-01-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64876Presman, Diego Martin; Hager, Gordon L.; More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?; Taylor ; Transcription; 8; 1; 8-1-2017; 32-392154-1272CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1080/21541264.2016.1249045info:eu-repo/semantics/altIdentifier/doi/10.1080/21541264.2016.1249045info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:06Zoai:ri.conicet.gov.ar:11336/64876instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:06.991CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| title |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| spellingShingle |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? Presman, Diego Martin DIMER DNA BINDING GLUCOCORTICOID RECEPTOR MONOMER STEROID RECEPTORS TETRAMER |
| title_short |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| title_full |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| title_fullStr |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| title_full_unstemmed |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| title_sort |
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? |
| dc.creator.none.fl_str_mv |
Presman, Diego Martin Hager, Gordon L. |
| author |
Presman, Diego Martin |
| author_facet |
Presman, Diego Martin Hager, Gordon L. |
| author_role |
author |
| author2 |
Hager, Gordon L. |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
DIMER DNA BINDING GLUCOCORTICOID RECEPTOR MONOMER STEROID RECEPTORS TETRAMER |
| topic |
DIMER DNA BINDING GLUCOCORTICOID RECEPTOR MONOMER STEROID RECEPTORS TETRAMER |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer. Fil: Presman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Institutes of Health; Estados Unidos Fil: Hager, Gordon L.. National Institutes of Health; Estados Unidos |
| description |
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-01-08 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/64876 Presman, Diego Martin; Hager, Gordon L.; More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?; Taylor ; Transcription; 8; 1; 8-1-2017; 32-39 2154-1272 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/64876 |
| identifier_str_mv |
Presman, Diego Martin; Hager, Gordon L.; More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?; Taylor ; Transcription; 8; 1; 8-1-2017; 32-39 2154-1272 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1080/21541264.2016.1249045 info:eu-repo/semantics/altIdentifier/doi/10.1080/21541264.2016.1249045 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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application/pdf application/pdf |
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Taylor |
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Taylor |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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