Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum

Autores
Rodriguez, María Victoria; Butassi, Estefanía; Funes, Matías Daniel; Zacchino, Susana Alicia Stella
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The new neo-clerodane dimer (DACD) likely formed by a [4+2] photo-cycloaddition between two molecules of ent-15,16-epoxy-19-hydroxy-1,3,13(16),14-clerodatetraen-18-oic acid (DAC), both isolated from Baccharis flabellata Hook et Arn. var. flabellata (Asteraceae), were tested in combination withterbinafine (Terb) against Trichophyton rubrum. The interactions were assessed with different methodologies such as 3D CombiTool software, LoeweCombination Index (CI) and isobolograms. Results showed that the monomer DAC as well as its dimer DACD act synergistically with Terb against T. rubrum.DAC/Terb and DACD/Terb showed eight and twelve synergistic mixtures respectively in the CombiTool graphics thus suggesting that DACD/Terb was moresynergistic with Terb than DAC. These results were corroborated by the CI values and the isobolograms of the detected combinations. DACD/Terb showedmuch lower CIs (0.34-0.47) than DAC/Terb (0.57-1.15) at the different inhibition percentages tested. Concomitantly, DACD/Terb isobolograms were moreconcave than for DAC/Terb at the different inhibition percentages. This is the first report showing antifungal synergistic interactions of neo-clerodanes dimers and add new evidences that neo-clerodanes monomers interact synergistically with Terb against T. rubrum.
Fil: Rodriguez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Butassi, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Funes, Matías Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Materia
TERBINAFINE
TRICHOPHYTON RUBRUM
NEO-CLERODANE MONOMER
NEO-CLERODANE DIMER
SYNERGISM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114492
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/114492
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrumRodriguez, María VictoriaButassi, EstefaníaFunes, Matías DanielZacchino, Susana Alicia StellaTERBINAFINETRICHOPHYTON RUBRUMNEO-CLERODANE MONOMERNEO-CLERODANE DIMERSYNERGISMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The new neo-clerodane dimer (DACD) likely formed by a [4+2] photo-cycloaddition between two molecules of ent-15,16-epoxy-19-hydroxy-1,3,13(16),14-clerodatetraen-18-oic acid (DAC), both isolated from Baccharis flabellata Hook et Arn. var. flabellata (Asteraceae), were tested in combination withterbinafine (Terb) against Trichophyton rubrum. The interactions were assessed with different methodologies such as 3D CombiTool software, LoeweCombination Index (CI) and isobolograms. Results showed that the monomer DAC as well as its dimer DACD act synergistically with Terb against T. rubrum.DAC/Terb and DACD/Terb showed eight and twelve synergistic mixtures respectively in the CombiTool graphics thus suggesting that DACD/Terb was moresynergistic with Terb than DAC. These results were corroborated by the CI values and the isobolograms of the detected combinations. DACD/Terb showedmuch lower CIs (0.34-0.47) than DAC/Terb (0.57-1.15) at the different inhibition percentages tested. Concomitantly, DACD/Terb isobolograms were moreconcave than for DAC/Terb at the different inhibition percentages. This is the first report showing antifungal synergistic interactions of neo-clerodanes dimers and add new evidences that neo-clerodanes monomers interact synergistically with Terb against T. rubrum.Fil: Rodriguez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Butassi, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Funes, Matías Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaNatural Products2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114492Rodriguez, María Victoria; Butassi, Estefanía; Funes, Matías Daniel; Zacchino, Susana Alicia Stella; Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum; Natural Products; Natural Product Communications; 14; 1; 1-2019; 1-41934-578X1555-9475CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177%2F1934578X1901400101info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1901400101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:39Zoai:ri.conicet.gov.ar:11336/114492instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:39.845CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
title Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
spellingShingle Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
Rodriguez, María Victoria
TERBINAFINE
TRICHOPHYTON RUBRUM
NEO-CLERODANE MONOMER
NEO-CLERODANE DIMER
SYNERGISM
title_short Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
title_full Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
title_fullStr Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
title_full_unstemmed Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
title_sort Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum
dc.creator.none.fl_str_mv Rodriguez, María Victoria
Butassi, Estefanía
Funes, Matías Daniel
Zacchino, Susana Alicia Stella
author Rodriguez, María Victoria
author_facet Rodriguez, María Victoria
Butassi, Estefanía
Funes, Matías Daniel
Zacchino, Susana Alicia Stella
author_role author
author2 Butassi, Estefanía
Funes, Matías Daniel
Zacchino, Susana Alicia Stella
author2_role author
author
author
dc.subject.none.fl_str_mv TERBINAFINE
TRICHOPHYTON RUBRUM
NEO-CLERODANE MONOMER
NEO-CLERODANE DIMER
SYNERGISM
topic TERBINAFINE
TRICHOPHYTON RUBRUM
NEO-CLERODANE MONOMER
NEO-CLERODANE DIMER
SYNERGISM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The new neo-clerodane dimer (DACD) likely formed by a [4+2] photo-cycloaddition between two molecules of ent-15,16-epoxy-19-hydroxy-1,3,13(16),14-clerodatetraen-18-oic acid (DAC), both isolated from Baccharis flabellata Hook et Arn. var. flabellata (Asteraceae), were tested in combination withterbinafine (Terb) against Trichophyton rubrum. The interactions were assessed with different methodologies such as 3D CombiTool software, LoeweCombination Index (CI) and isobolograms. Results showed that the monomer DAC as well as its dimer DACD act synergistically with Terb against T. rubrum.DAC/Terb and DACD/Terb showed eight and twelve synergistic mixtures respectively in the CombiTool graphics thus suggesting that DACD/Terb was moresynergistic with Terb than DAC. These results were corroborated by the CI values and the isobolograms of the detected combinations. DACD/Terb showedmuch lower CIs (0.34-0.47) than DAC/Terb (0.57-1.15) at the different inhibition percentages tested. Concomitantly, DACD/Terb isobolograms were moreconcave than for DAC/Terb at the different inhibition percentages. This is the first report showing antifungal synergistic interactions of neo-clerodanes dimers and add new evidences that neo-clerodanes monomers interact synergistically with Terb against T. rubrum.
Fil: Rodriguez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Butassi, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Funes, Matías Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
description The new neo-clerodane dimer (DACD) likely formed by a [4+2] photo-cycloaddition between two molecules of ent-15,16-epoxy-19-hydroxy-1,3,13(16),14-clerodatetraen-18-oic acid (DAC), both isolated from Baccharis flabellata Hook et Arn. var. flabellata (Asteraceae), were tested in combination withterbinafine (Terb) against Trichophyton rubrum. The interactions were assessed with different methodologies such as 3D CombiTool software, LoeweCombination Index (CI) and isobolograms. Results showed that the monomer DAC as well as its dimer DACD act synergistically with Terb against T. rubrum.DAC/Terb and DACD/Terb showed eight and twelve synergistic mixtures respectively in the CombiTool graphics thus suggesting that DACD/Terb was moresynergistic with Terb than DAC. These results were corroborated by the CI values and the isobolograms of the detected combinations. DACD/Terb showedmuch lower CIs (0.34-0.47) than DAC/Terb (0.57-1.15) at the different inhibition percentages tested. Concomitantly, DACD/Terb isobolograms were moreconcave than for DAC/Terb at the different inhibition percentages. This is the first report showing antifungal synergistic interactions of neo-clerodanes dimers and add new evidences that neo-clerodanes monomers interact synergistically with Terb against T. rubrum.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114492
Rodriguez, María Victoria; Butassi, Estefanía; Funes, Matías Daniel; Zacchino, Susana Alicia Stella; Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum; Natural Products; Natural Product Communications; 14; 1; 1-2019; 1-4
1934-578X
1555-9475
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114492
identifier_str_mv Rodriguez, María Victoria; Butassi, Estefanía; Funes, Matías Daniel; Zacchino, Susana Alicia Stella; Synergism between Terbinafine and a Neo-clerodane Dimer or a Monomer Isolated from Baccharis flabellata against Trichophyton rubrum; Natural Products; Natural Product Communications; 14; 1; 1-2019; 1-4
1934-578X
1555-9475
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177%2F1934578X1901400101
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1901400101
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Natural Products
publisher.none.fl_str_mv Natural Products
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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