Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw

Autores
Picardo, S.N.; Rodriguez Genta, S.A.; Seijo, Mariana; Zeni, Susana Noemi; Rey, E.A.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bisphosphonates (BPs) are anticatabolic drugs of choice for treating bone diseases, includingbone metastases. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the possiblecomplications. Crosslaps (CTX) could be used as biochemical marker for risk of developing ONJ. VitaminD (VD) may be involved in this condition. VD status and CTX levels were evaluated and compared in BPtreated women without BRONJ (Group I; n=28) and with BRONJ (Group II; n=58). Women were older andduration of BP use was longer in Group II (p=0.0000036). No differences in calcemia, phosphatemia, orCTX levels were observed; BAP levels were significantly higher and 25OHD were significantly lower inGroup II (p=0.040 and p=0.035, respectively). The percentage of subjects with CTX levels between 100and 149mg/mL was similar in both groups. VD deficiency was observed in 18% of subjects in Group IIbut in none of the subjects in Group I. No significant differences in the percentage of subjects with VDinsufficiency and sufficiency were observed between groups (Group I: 50%; Group II: 40%). Conclusion:CTX levels did not prove useful as predictors of risk for developing BRONJ. The high percentage of womenwith VD deficiency who developed BRONJ suggests a possible relationship between both conditions andhighlights the importance of assessing Vitamin D status.
Fil: Picardo, S.N.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; Argentina
Fil: Rodriguez Genta, S.A.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; Argentina
Fil: Seijo, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Rey, E.A.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; Argentina
Materia
Bisphosphonates
Osteonecrosis of the jaw
CTX
Vitamin D
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140083
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/140083
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the JawPicardo, S.N.Rodriguez Genta, S.A.Seijo, MarianaZeni, Susana NoemiRey, E.A.BisphosphonatesOsteonecrosis of the jawCTXVitamin Dhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Bisphosphonates (BPs) are anticatabolic drugs of choice for treating bone diseases, includingbone metastases. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the possiblecomplications. Crosslaps (CTX) could be used as biochemical marker for risk of developing ONJ. VitaminD (VD) may be involved in this condition. VD status and CTX levels were evaluated and compared in BPtreated women without BRONJ (Group I; n=28) and with BRONJ (Group II; n=58). Women were older andduration of BP use was longer in Group II (p=0.0000036). No differences in calcemia, phosphatemia, orCTX levels were observed; BAP levels were significantly higher and 25OHD were significantly lower inGroup II (p=0.040 and p=0.035, respectively). The percentage of subjects with CTX levels between 100and 149mg/mL was similar in both groups. VD deficiency was observed in 18% of subjects in Group IIbut in none of the subjects in Group I. No significant differences in the percentage of subjects with VDinsufficiency and sufficiency were observed between groups (Group I: 50%; Group II: 40%). Conclusion:CTX levels did not prove useful as predictors of risk for developing BRONJ. The high percentage of womenwith VD deficiency who developed BRONJ suggests a possible relationship between both conditions andhighlights the importance of assessing Vitamin D status.Fil: Picardo, S.N.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; ArgentinaFil: Rodriguez Genta, S.A.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; ArgentinaFil: Seijo, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Rey, E.A.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; ArgentinaCrimson Publishing2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140083Picardo, S.N.; Rodriguez Genta, S.A.; Seijo, Mariana; Zeni, Susana Noemi; Rey, E.A.; Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw; Crimson Publishing; Global Journal of Endrocrinological Metabolism; 3; 3; 11-2020; 1-82637-8019CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://crimsonpublishers.com/gjem/pdf/GJEM.000561.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:58:01Zoai:ri.conicet.gov.ar:11336/140083instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:58:01.555CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
title Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
spellingShingle Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
Picardo, S.N.
Bisphosphonates
Osteonecrosis of the jaw
CTX
Vitamin D
title_short Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
title_full Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
title_fullStr Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
title_full_unstemmed Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
title_sort Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw
dc.creator.none.fl_str_mv Picardo, S.N.
Rodriguez Genta, S.A.
Seijo, Mariana
Zeni, Susana Noemi
Rey, E.A.
author Picardo, S.N.
author_facet Picardo, S.N.
Rodriguez Genta, S.A.
Seijo, Mariana
Zeni, Susana Noemi
Rey, E.A.
author_role author
author2 Rodriguez Genta, S.A.
Seijo, Mariana
Zeni, Susana Noemi
Rey, E.A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bisphosphonates
Osteonecrosis of the jaw
CTX
Vitamin D
topic Bisphosphonates
Osteonecrosis of the jaw
CTX
Vitamin D
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Bisphosphonates (BPs) are anticatabolic drugs of choice for treating bone diseases, includingbone metastases. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the possiblecomplications. Crosslaps (CTX) could be used as biochemical marker for risk of developing ONJ. VitaminD (VD) may be involved in this condition. VD status and CTX levels were evaluated and compared in BPtreated women without BRONJ (Group I; n=28) and with BRONJ (Group II; n=58). Women were older andduration of BP use was longer in Group II (p=0.0000036). No differences in calcemia, phosphatemia, orCTX levels were observed; BAP levels were significantly higher and 25OHD were significantly lower inGroup II (p=0.040 and p=0.035, respectively). The percentage of subjects with CTX levels between 100and 149mg/mL was similar in both groups. VD deficiency was observed in 18% of subjects in Group IIbut in none of the subjects in Group I. No significant differences in the percentage of subjects with VDinsufficiency and sufficiency were observed between groups (Group I: 50%; Group II: 40%). Conclusion:CTX levels did not prove useful as predictors of risk for developing BRONJ. The high percentage of womenwith VD deficiency who developed BRONJ suggests a possible relationship between both conditions andhighlights the importance of assessing Vitamin D status.
Fil: Picardo, S.N.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; Argentina
Fil: Rodriguez Genta, S.A.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; Argentina
Fil: Seijo, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Rey, E.A.. Universidad de Buenos Aires. Facultad de Odontologia. Hospital Odontologico Universitario.; Argentina
description Bisphosphonates (BPs) are anticatabolic drugs of choice for treating bone diseases, includingbone metastases. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the possiblecomplications. Crosslaps (CTX) could be used as biochemical marker for risk of developing ONJ. VitaminD (VD) may be involved in this condition. VD status and CTX levels were evaluated and compared in BPtreated women without BRONJ (Group I; n=28) and with BRONJ (Group II; n=58). Women were older andduration of BP use was longer in Group II (p=0.0000036). No differences in calcemia, phosphatemia, orCTX levels were observed; BAP levels were significantly higher and 25OHD were significantly lower inGroup II (p=0.040 and p=0.035, respectively). The percentage of subjects with CTX levels between 100and 149mg/mL was similar in both groups. VD deficiency was observed in 18% of subjects in Group IIbut in none of the subjects in Group I. No significant differences in the percentage of subjects with VDinsufficiency and sufficiency were observed between groups (Group I: 50%; Group II: 40%). Conclusion:CTX levels did not prove useful as predictors of risk for developing BRONJ. The high percentage of womenwith VD deficiency who developed BRONJ suggests a possible relationship between both conditions andhighlights the importance of assessing Vitamin D status.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140083
Picardo, S.N.; Rodriguez Genta, S.A.; Seijo, Mariana; Zeni, Susana Noemi; Rey, E.A.; Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw; Crimson Publishing; Global Journal of Endrocrinological Metabolism; 3; 3; 11-2020; 1-8
2637-8019
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140083
identifier_str_mv Picardo, S.N.; Rodriguez Genta, S.A.; Seijo, Mariana; Zeni, Susana Noemi; Rey, E.A.; Serum Crosslaps (CTX) and 25hydroxyvitamin D Levels as Risk Predictors of Bisphosphonate- Related Osteonecrosis of the Jaw; Crimson Publishing; Global Journal of Endrocrinological Metabolism; 3; 3; 11-2020; 1-8
2637-8019
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://crimsonpublishers.com/gjem/pdf/GJEM.000561.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Crimson Publishing
publisher.none.fl_str_mv Crimson Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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