Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis

Autores
García Mendívil, Laura; Pérez Zabalza, María; Mountris, Konstantinos; Duwé, Sam; Smisdom, Nick; Pérez, Marta; Luján, Lluís; Wolfs, Esther; Driesen, Ronald B.; Vallejo Gil, José María; Fresneda Roldán, Pedro Carlos; Fañanás Mastral, Javier; Vázquez Sancho, Manuel; Matamala Adell, Marta; Sorribas Berjón, Juan Fernando; Bellido Morales, Javier André; Mancebón Sierra, Francisco Javier; Vaca Núñez, Alexánder Sebastián; Ballester Cuenca, Carlos; Oliván Viguera, Aida; Diez, Emiliano Raúl; Ordovás, Laura; Pueyo, Esther
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics.
Fil: García Mendívil, Laura. Universidad de Zaragoza; España. BSICoS; España
Fil: Pérez Zabalza, María. Universidad de Zaragoza; España. BSICoS; España
Fil: Mountris, Konstantinos. Universidad de Zaragoza; España. BSICoS; España
Fil: Duwé, Sam. Hasselt University; Bélgica
Fil: Smisdom, Nick. Hasselt University; Bélgica
Fil: Pérez, Marta. Universidad de Zaragoza; España
Fil: Luján, Lluís. Universidad de Zaragoza; España
Fil: Wolfs, Esther. Hasselt University; Bélgica
Fil: Driesen, Ronald B.. Hasselt University; Bélgica
Fil: Vallejo Gil, José María. Universidad de Zaragoza; España
Fil: Fresneda Roldán, Pedro Carlos. Universidad de Zaragoza; España
Fil: Fañanás Mastral, Javier. Universidad de Zaragoza; España
Fil: Vázquez Sancho, Manuel. Universidad de Zaragoza; España
Fil: Matamala Adell, Marta. Universidad de Zaragoza; España
Fil: Sorribas Berjón, Juan Fernando. Universidad de Zaragoza; España
Fil: Bellido Morales, Javier André. Universidad de Zaragoza; España
Fil: Mancebón Sierra, Francisco Javier. Universidad de Zaragoza; España
Fil: Vaca Núñez, Alexánder Sebastián. Universidad de Zaragoza; España
Fil: Ballester Cuenca, Carlos. Universidad de Zaragoza; España
Fil: Oliván Viguera, Aida. Universidad de Zaragoza; España. BSICoS; España. Centro de Investigación en Red en Bioingeniería; España
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Ordovás, Laura. Universidad de Zaragoza; España. BSICoS; España. ARAID Foundation; España
Fil: Pueyo, Esther. Universidad de Zaragoza; España. BSICoS; España. Centro de Investigación en Red en Bioingeniería; España
Materia
COMPUTATIONAL BIOINFORMATICS
DISEASE
PATHOPHYSIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/232138
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/232138
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesisGarcía Mendívil, LauraPérez Zabalza, MaríaMountris, KonstantinosDuwé, SamSmisdom, NickPérez, MartaLuján, LluísWolfs, EstherDriesen, Ronald B.Vallejo Gil, José MaríaFresneda Roldán, Pedro CarlosFañanás Mastral, JavierVázquez Sancho, ManuelMatamala Adell, MartaSorribas Berjón, Juan FernandoBellido Morales, Javier AndréMancebón Sierra, Francisco JavierVaca Núñez, Alexánder SebastiánBallester Cuenca, CarlosOliván Viguera, AidaDiez, Emiliano RaúlOrdovás, LauraPueyo, EstherCOMPUTATIONAL BIOINFORMATICSDISEASEPATHOPHYSIOLOGYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics.Fil: García Mendívil, Laura. Universidad de Zaragoza; España. BSICoS; EspañaFil: Pérez Zabalza, María. Universidad de Zaragoza; España. BSICoS; EspañaFil: Mountris, Konstantinos. Universidad de Zaragoza; España. BSICoS; EspañaFil: Duwé, Sam. Hasselt University; BélgicaFil: Smisdom, Nick. Hasselt University; BélgicaFil: Pérez, Marta. Universidad de Zaragoza; EspañaFil: Luján, Lluís. Universidad de Zaragoza; EspañaFil: Wolfs, Esther. Hasselt University; BélgicaFil: Driesen, Ronald B.. Hasselt University; BélgicaFil: Vallejo Gil, José María. Universidad de Zaragoza; EspañaFil: Fresneda Roldán, Pedro Carlos. Universidad de Zaragoza; EspañaFil: Fañanás Mastral, Javier. Universidad de Zaragoza; EspañaFil: Vázquez Sancho, Manuel. Universidad de Zaragoza; EspañaFil: Matamala Adell, Marta. Universidad de Zaragoza; EspañaFil: Sorribas Berjón, Juan Fernando. Universidad de Zaragoza; EspañaFil: Bellido Morales, Javier André. Universidad de Zaragoza; EspañaFil: Mancebón Sierra, Francisco Javier. Universidad de Zaragoza; EspañaFil: Vaca Núñez, Alexánder Sebastián. Universidad de Zaragoza; EspañaFil: Ballester Cuenca, Carlos. Universidad de Zaragoza; EspañaFil: Oliván Viguera, Aida. Universidad de Zaragoza; España. BSICoS; España. Centro de Investigación en Red en Bioingeniería; EspañaFil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; ArgentinaFil: Ordovás, Laura. Universidad de Zaragoza; España. BSICoS; España. ARAID Foundation; EspañaFil: Pueyo, Esther. Universidad de Zaragoza; España. BSICoS; España. Centro de Investigación en Red en Bioingeniería; EspañaCell Press2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/232138García Mendívil, Laura; Pérez Zabalza, María; Mountris, Konstantinos; Duwé, Sam; Smisdom, Nick; et al.; Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis; Cell Press; iScience; 25; 2; 2-2022; 1-202589-0042CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S258900422200092Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.isci.2022.103822info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:53Zoai:ri.conicet.gov.ar:11336/232138instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:54.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
title Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
spellingShingle Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
García Mendívil, Laura
COMPUTATIONAL BIOINFORMATICS
DISEASE
PATHOPHYSIOLOGY
title_short Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
title_full Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
title_fullStr Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
title_full_unstemmed Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
title_sort Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
dc.creator.none.fl_str_mv García Mendívil, Laura
Pérez Zabalza, María
Mountris, Konstantinos
Duwé, Sam
Smisdom, Nick
Pérez, Marta
Luján, Lluís
Wolfs, Esther
Driesen, Ronald B.
Vallejo Gil, José María
Fresneda Roldán, Pedro Carlos
Fañanás Mastral, Javier
Vázquez Sancho, Manuel
Matamala Adell, Marta
Sorribas Berjón, Juan Fernando
Bellido Morales, Javier André
Mancebón Sierra, Francisco Javier
Vaca Núñez, Alexánder Sebastián
Ballester Cuenca, Carlos
Oliván Viguera, Aida
Diez, Emiliano Raúl
Ordovás, Laura
Pueyo, Esther
author García Mendívil, Laura
author_facet García Mendívil, Laura
Pérez Zabalza, María
Mountris, Konstantinos
Duwé, Sam
Smisdom, Nick
Pérez, Marta
Luján, Lluís
Wolfs, Esther
Driesen, Ronald B.
Vallejo Gil, José María
Fresneda Roldán, Pedro Carlos
Fañanás Mastral, Javier
Vázquez Sancho, Manuel
Matamala Adell, Marta
Sorribas Berjón, Juan Fernando
Bellido Morales, Javier André
Mancebón Sierra, Francisco Javier
Vaca Núñez, Alexánder Sebastián
Ballester Cuenca, Carlos
Oliván Viguera, Aida
Diez, Emiliano Raúl
Ordovás, Laura
Pueyo, Esther
author_role author
author2 Pérez Zabalza, María
Mountris, Konstantinos
Duwé, Sam
Smisdom, Nick
Pérez, Marta
Luján, Lluís
Wolfs, Esther
Driesen, Ronald B.
Vallejo Gil, José María
Fresneda Roldán, Pedro Carlos
Fañanás Mastral, Javier
Vázquez Sancho, Manuel
Matamala Adell, Marta
Sorribas Berjón, Juan Fernando
Bellido Morales, Javier André
Mancebón Sierra, Francisco Javier
Vaca Núñez, Alexánder Sebastián
Ballester Cuenca, Carlos
Oliván Viguera, Aida
Diez, Emiliano Raúl
Ordovás, Laura
Pueyo, Esther
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COMPUTATIONAL BIOINFORMATICS
DISEASE
PATHOPHYSIOLOGY
topic COMPUTATIONAL BIOINFORMATICS
DISEASE
PATHOPHYSIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics.
Fil: García Mendívil, Laura. Universidad de Zaragoza; España. BSICoS; España
Fil: Pérez Zabalza, María. Universidad de Zaragoza; España. BSICoS; España
Fil: Mountris, Konstantinos. Universidad de Zaragoza; España. BSICoS; España
Fil: Duwé, Sam. Hasselt University; Bélgica
Fil: Smisdom, Nick. Hasselt University; Bélgica
Fil: Pérez, Marta. Universidad de Zaragoza; España
Fil: Luján, Lluís. Universidad de Zaragoza; España
Fil: Wolfs, Esther. Hasselt University; Bélgica
Fil: Driesen, Ronald B.. Hasselt University; Bélgica
Fil: Vallejo Gil, José María. Universidad de Zaragoza; España
Fil: Fresneda Roldán, Pedro Carlos. Universidad de Zaragoza; España
Fil: Fañanás Mastral, Javier. Universidad de Zaragoza; España
Fil: Vázquez Sancho, Manuel. Universidad de Zaragoza; España
Fil: Matamala Adell, Marta. Universidad de Zaragoza; España
Fil: Sorribas Berjón, Juan Fernando. Universidad de Zaragoza; España
Fil: Bellido Morales, Javier André. Universidad de Zaragoza; España
Fil: Mancebón Sierra, Francisco Javier. Universidad de Zaragoza; España
Fil: Vaca Núñez, Alexánder Sebastián. Universidad de Zaragoza; España
Fil: Ballester Cuenca, Carlos. Universidad de Zaragoza; España
Fil: Oliván Viguera, Aida. Universidad de Zaragoza; España. BSICoS; España. Centro de Investigación en Red en Bioingeniería; España
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Ordovás, Laura. Universidad de Zaragoza; España. BSICoS; España. ARAID Foundation; España
Fil: Pueyo, Esther. Universidad de Zaragoza; España. BSICoS; España. Centro de Investigación en Red en Bioingeniería; España
description Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/232138
García Mendívil, Laura; Pérez Zabalza, María; Mountris, Konstantinos; Duwé, Sam; Smisdom, Nick; et al.; Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis; Cell Press; iScience; 25; 2; 2-2022; 1-20
2589-0042
CONICET Digital
CONICET
url http://hdl.handle.net/11336/232138
identifier_str_mv García Mendívil, Laura; Pérez Zabalza, María; Mountris, Konstantinos; Duwé, Sam; Smisdom, Nick; et al.; Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis; Cell Press; iScience; 25; 2; 2-2022; 1-20
2589-0042
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S258900422200092X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.isci.2022.103822
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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