Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice

Autores
Navarro, Ana; Sánchez Pino, Maria Jesús; Gómez, Carmen; Bández, Manuel J.; Cadenas, Enrique; Boveris, Alberto Antonio
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Male mice on a diet supplemented with thioproline (l-thiazolidine-4-carboxylic acid), a physiological metabolite of 5-hydroxytryptamine, at 2.0 g/kg of food from 28 weeks of age and for their entire life, showed a 23-29% increased median and maximal life span. These survival increases were associated with improved neurological functions. Compared to control mice, thioproline-supplemented mice had a 20% lower integral spontaneous food intake, and 10% lower body weight at 100 weeks of age. Body weight showed a statistically significant inverse relationship with survival and neurological performances. Thioproline-supplemented mice exhibited a 58-70% decrease of the age-dependent oxidative damage in brain and liver mitochondria at 52 weeks (old mice) and 78 weeks (senescent mice) of age, respectively. The age-associated decrease of brain mitochondrial enzyme activities, NADH-dehydrogenase, cytochrome c oxidase, and mitochondrial nitric oxide synthase (mtNOS), in old and senescent mice were markedly prevented (51-74%) by thioproline. In vitro, thioproline neither exhibited direct antioxidant activity nor had any effect on the electron transfer or mtNOS functional activities of brain and liver mitochondria. It is surmised that thioproline induces an anorexic effect associated with improved survival and neurological function through a decreased oxidative damage and regulation that may involve hypothalamic appetite centers.
Fil: Navarro, Ana. Universidad de Cádiz; España
Fil: Sánchez Pino, Maria Jesús. Universidad de Cádiz; España
Fil: Gómez, Carmen. Universidad de Cádiz; España
Fil: Bández, Manuel J.. Universidad de Cádiz; España
Fil: Cadenas, Enrique. University of Southern California; Estados Unidos
Fil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
THIOPROLINE
SURVIVAL
NADH-DEHYDROGENASE
NITRIC OXIDE SYNTHASE
CITOCHROME C OXIDASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/254436
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/254436
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in MiceNavarro, AnaSánchez Pino, Maria JesúsGómez, CarmenBández, Manuel J.Cadenas, EnriqueBoveris, Alberto AntonioTHIOPROLINESURVIVALNADH-DEHYDROGENASENITRIC OXIDE SYNTHASECITOCHROME C OXIDASEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Male mice on a diet supplemented with thioproline (l-thiazolidine-4-carboxylic acid), a physiological metabolite of 5-hydroxytryptamine, at 2.0 g/kg of food from 28 weeks of age and for their entire life, showed a 23-29% increased median and maximal life span. These survival increases were associated with improved neurological functions. Compared to control mice, thioproline-supplemented mice had a 20% lower integral spontaneous food intake, and 10% lower body weight at 100 weeks of age. Body weight showed a statistically significant inverse relationship with survival and neurological performances. Thioproline-supplemented mice exhibited a 58-70% decrease of the age-dependent oxidative damage in brain and liver mitochondria at 52 weeks (old mice) and 78 weeks (senescent mice) of age, respectively. The age-associated decrease of brain mitochondrial enzyme activities, NADH-dehydrogenase, cytochrome c oxidase, and mitochondrial nitric oxide synthase (mtNOS), in old and senescent mice were markedly prevented (51-74%) by thioproline. In vitro, thioproline neither exhibited direct antioxidant activity nor had any effect on the electron transfer or mtNOS functional activities of brain and liver mitochondria. It is surmised that thioproline induces an anorexic effect associated with improved survival and neurological function through a decreased oxidative damage and regulation that may involve hypothalamic appetite centers.Fil: Navarro, Ana. Universidad de Cádiz; EspañaFil: Sánchez Pino, Maria Jesús. Universidad de Cádiz; EspañaFil: Gómez, Carmen. Universidad de Cádiz; EspañaFil: Bández, Manuel J.. Universidad de Cádiz; EspañaFil: Cadenas, Enrique. University of Southern California; Estados UnidosFil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaMary Ann Liebert2007-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/254436Navarro, Ana; Sánchez Pino, Maria Jesús; Gómez, Carmen; Bández, Manuel J.; Cadenas, Enrique; et al.; Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice; Mary Ann Liebert; Antioxidants & Redox Signaling; 9; 1; 1-2007; 131-1411523-0864CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/ars.2007.9.131info:eu-repo/semantics/altIdentifier/doi/10.1089/ars.2007.9.131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:58Zoai:ri.conicet.gov.ar:11336/254436instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:59.261CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
title Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
spellingShingle Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
Navarro, Ana
THIOPROLINE
SURVIVAL
NADH-DEHYDROGENASE
NITRIC OXIDE SYNTHASE
CITOCHROME C OXIDASE
title_short Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
title_full Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
title_fullStr Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
title_full_unstemmed Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
title_sort Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice
dc.creator.none.fl_str_mv Navarro, Ana
Sánchez Pino, Maria Jesús
Gómez, Carmen
Bández, Manuel J.
Cadenas, Enrique
Boveris, Alberto Antonio
author Navarro, Ana
author_facet Navarro, Ana
Sánchez Pino, Maria Jesús
Gómez, Carmen
Bández, Manuel J.
Cadenas, Enrique
Boveris, Alberto Antonio
author_role author
author2 Sánchez Pino, Maria Jesús
Gómez, Carmen
Bández, Manuel J.
Cadenas, Enrique
Boveris, Alberto Antonio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv THIOPROLINE
SURVIVAL
NADH-DEHYDROGENASE
NITRIC OXIDE SYNTHASE
CITOCHROME C OXIDASE
topic THIOPROLINE
SURVIVAL
NADH-DEHYDROGENASE
NITRIC OXIDE SYNTHASE
CITOCHROME C OXIDASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Male mice on a diet supplemented with thioproline (l-thiazolidine-4-carboxylic acid), a physiological metabolite of 5-hydroxytryptamine, at 2.0 g/kg of food from 28 weeks of age and for their entire life, showed a 23-29% increased median and maximal life span. These survival increases were associated with improved neurological functions. Compared to control mice, thioproline-supplemented mice had a 20% lower integral spontaneous food intake, and 10% lower body weight at 100 weeks of age. Body weight showed a statistically significant inverse relationship with survival and neurological performances. Thioproline-supplemented mice exhibited a 58-70% decrease of the age-dependent oxidative damage in brain and liver mitochondria at 52 weeks (old mice) and 78 weeks (senescent mice) of age, respectively. The age-associated decrease of brain mitochondrial enzyme activities, NADH-dehydrogenase, cytochrome c oxidase, and mitochondrial nitric oxide synthase (mtNOS), in old and senescent mice were markedly prevented (51-74%) by thioproline. In vitro, thioproline neither exhibited direct antioxidant activity nor had any effect on the electron transfer or mtNOS functional activities of brain and liver mitochondria. It is surmised that thioproline induces an anorexic effect associated with improved survival and neurological function through a decreased oxidative damage and regulation that may involve hypothalamic appetite centers.
Fil: Navarro, Ana. Universidad de Cádiz; España
Fil: Sánchez Pino, Maria Jesús. Universidad de Cádiz; España
Fil: Gómez, Carmen. Universidad de Cádiz; España
Fil: Bández, Manuel J.. Universidad de Cádiz; España
Fil: Cadenas, Enrique. University of Southern California; Estados Unidos
Fil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description Male mice on a diet supplemented with thioproline (l-thiazolidine-4-carboxylic acid), a physiological metabolite of 5-hydroxytryptamine, at 2.0 g/kg of food from 28 weeks of age and for their entire life, showed a 23-29% increased median and maximal life span. These survival increases were associated with improved neurological functions. Compared to control mice, thioproline-supplemented mice had a 20% lower integral spontaneous food intake, and 10% lower body weight at 100 weeks of age. Body weight showed a statistically significant inverse relationship with survival and neurological performances. Thioproline-supplemented mice exhibited a 58-70% decrease of the age-dependent oxidative damage in brain and liver mitochondria at 52 weeks (old mice) and 78 weeks (senescent mice) of age, respectively. The age-associated decrease of brain mitochondrial enzyme activities, NADH-dehydrogenase, cytochrome c oxidase, and mitochondrial nitric oxide synthase (mtNOS), in old and senescent mice were markedly prevented (51-74%) by thioproline. In vitro, thioproline neither exhibited direct antioxidant activity nor had any effect on the electron transfer or mtNOS functional activities of brain and liver mitochondria. It is surmised that thioproline induces an anorexic effect associated with improved survival and neurological function through a decreased oxidative damage and regulation that may involve hypothalamic appetite centers.
publishDate 2007
dc.date.none.fl_str_mv 2007-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/254436
Navarro, Ana; Sánchez Pino, Maria Jesús; Gómez, Carmen; Bández, Manuel J.; Cadenas, Enrique; et al.; Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice; Mary Ann Liebert; Antioxidants & Redox Signaling; 9; 1; 1-2007; 131-141
1523-0864
CONICET Digital
CONICET
url http://hdl.handle.net/11336/254436
identifier_str_mv Navarro, Ana; Sánchez Pino, Maria Jesús; Gómez, Carmen; Bández, Manuel J.; Cadenas, Enrique; et al.; Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice; Mary Ann Liebert; Antioxidants & Redox Signaling; 9; 1; 1-2007; 131-141
1523-0864
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/ars.2007.9.131
info:eu-repo/semantics/altIdentifier/doi/10.1089/ars.2007.9.131
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082592924762112
score 13.221938

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