Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin

Autores
Vanden Braber, Noelia Luciana; Paredes, Alejandro Javier; Rossi, Yanina Estefanía; Porporatto, Carina; Allemandi, Daniel Alberto; Borsarelli, Claudio Darío; Correa, Silvia Graciela; Montenegro, Mariana Angélica
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinked microcapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) as wall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-drying technique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5 μm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, being the release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almost double than those made with Ch under gastric conditions, but the same release rate was observed for both Qr-MC under intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) including hydroxyl radical HO • , anion superoxide O 2 •− and singlet oxygen 1 O 2 was observed, indicating that Ch biopolymers are also suitable functional coating materials for flavonoid microencapsulation, regarding the gastro resistance, antioxidant activity and controlled release properties that could increase the bioavailability of the flavonoid.
Fil: Vanden Braber, Noelia Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Porporatto, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina; Argentina
Fil: Borsarelli, Claudio Darío. Instituto de Bionanotecnología del NOA, (INBIONATEC), Universidad Nacional de Santiago del Estero (UNSE), CONICET; Argentina
Fil: Silvia G. Correa. Centro de Investigación en Bioquímica Clínica e Inmunología (CIBICI- CONICET), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina; Argentina
Fil: Mariana A. Montenegro. Centro de Investigaciones y Transferencia de Villa María (CITVM-CONICET), Universidad Nacional de Villa María, Campus Universitario, Arturo Jauretche 1555, Villa María, Córdoba, Argentina; Argentina
Materia
CHITOSAN
CONTROLLED RELEASE
CROSSLINKING
MICROCAPSULES
REACTIVE OXYGEN SPECIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92601
Acceder
id CONICETDig_e4c2cb57ea664d107ef633decc170ec0
oai_identifier_str oai:ri.conicet.gov.ar:11336/92601
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetinVanden Braber, Noelia LucianaParedes, Alejandro JavierRossi, Yanina EstefaníaPorporatto, CarinaAllemandi, Daniel AlbertoBorsarelli, Claudio DaríoCorrea, Silvia GracielaMontenegro, Mariana AngélicaCHITOSANCONTROLLED RELEASECROSSLINKINGMICROCAPSULESREACTIVE OXYGEN SPECIEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinked microcapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) as wall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-drying technique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5 μm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, being the release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almost double than those made with Ch under gastric conditions, but the same release rate was observed for both Qr-MC under intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) including hydroxyl radical HO • , anion superoxide O 2 •− and singlet oxygen 1 O 2 was observed, indicating that Ch biopolymers are also suitable functional coating materials for flavonoid microencapsulation, regarding the gastro resistance, antioxidant activity and controlled release properties that could increase the bioavailability of the flavonoid.Fil: Vanden Braber, Noelia Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Porporatto, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; ArgentinaFil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina; ArgentinaFil: Borsarelli, Claudio Darío. Instituto de Bionanotecnología del NOA, (INBIONATEC), Universidad Nacional de Santiago del Estero (UNSE), CONICET; ArgentinaFil: Silvia G. Correa. Centro de Investigación en Bioquímica Clínica e Inmunología (CIBICI- CONICET), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina; ArgentinaFil: Mariana A. Montenegro. Centro de Investigaciones y Transferencia de Villa María (CITVM-CONICET), Universidad Nacional de Villa María, Campus Universitario, Arturo Jauretche 1555, Villa María, Córdoba, Argentina; ArgentinaElsevier Science2018-06-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92601Vanden Braber, Noelia Luciana; Paredes, Alejandro Javier; Rossi, Yanina Estefanía; Porporatto, Carina; Allemandi, Daniel Alberto; et al.; Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin; Elsevier Science; International Journal of Biological Macromolecules; 112; 13-6-2018; 399-4040141-8130CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0141813017338667info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2018.01.085info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:40Zoai:ri.conicet.gov.ar:11336/92601instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:41.049CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
title Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
spellingShingle Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
Vanden Braber, Noelia Luciana
CHITOSAN
CONTROLLED RELEASE
CROSSLINKING
MICROCAPSULES
REACTIVE OXYGEN SPECIES
title_short Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
title_full Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
title_fullStr Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
title_full_unstemmed Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
title_sort Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
dc.creator.none.fl_str_mv Vanden Braber, Noelia Luciana
Paredes, Alejandro Javier
Rossi, Yanina Estefanía
Porporatto, Carina
Allemandi, Daniel Alberto
Borsarelli, Claudio Darío
Correa, Silvia Graciela
Montenegro, Mariana Angélica
author Vanden Braber, Noelia Luciana
author_facet Vanden Braber, Noelia Luciana
Paredes, Alejandro Javier
Rossi, Yanina Estefanía
Porporatto, Carina
Allemandi, Daniel Alberto
Borsarelli, Claudio Darío
Correa, Silvia Graciela
Montenegro, Mariana Angélica
author_role author
author2 Paredes, Alejandro Javier
Rossi, Yanina Estefanía
Porporatto, Carina
Allemandi, Daniel Alberto
Borsarelli, Claudio Darío
Correa, Silvia Graciela
Montenegro, Mariana Angélica
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHITOSAN
CONTROLLED RELEASE
CROSSLINKING
MICROCAPSULES
REACTIVE OXYGEN SPECIES
topic CHITOSAN
CONTROLLED RELEASE
CROSSLINKING
MICROCAPSULES
REACTIVE OXYGEN SPECIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinked microcapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) as wall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-drying technique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5 μm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, being the release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almost double than those made with Ch under gastric conditions, but the same release rate was observed for both Qr-MC under intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) including hydroxyl radical HO • , anion superoxide O 2 •− and singlet oxygen 1 O 2 was observed, indicating that Ch biopolymers are also suitable functional coating materials for flavonoid microencapsulation, regarding the gastro resistance, antioxidant activity and controlled release properties that could increase the bioavailability of the flavonoid.
Fil: Vanden Braber, Noelia Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Porporatto, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina; Argentina
Fil: Borsarelli, Claudio Darío. Instituto de Bionanotecnología del NOA, (INBIONATEC), Universidad Nacional de Santiago del Estero (UNSE), CONICET; Argentina
Fil: Silvia G. Correa. Centro de Investigación en Bioquímica Clínica e Inmunología (CIBICI- CONICET), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina; Argentina
Fil: Mariana A. Montenegro. Centro de Investigaciones y Transferencia de Villa María (CITVM-CONICET), Universidad Nacional de Villa María, Campus Universitario, Arturo Jauretche 1555, Villa María, Córdoba, Argentina; Argentina
description The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinked microcapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) as wall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-drying technique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5 μm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, being the release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almost double than those made with Ch under gastric conditions, but the same release rate was observed for both Qr-MC under intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) including hydroxyl radical HO • , anion superoxide O 2 •− and singlet oxygen 1 O 2 was observed, indicating that Ch biopolymers are also suitable functional coating materials for flavonoid microencapsulation, regarding the gastro resistance, antioxidant activity and controlled release properties that could increase the bioavailability of the flavonoid.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92601
Vanden Braber, Noelia Luciana; Paredes, Alejandro Javier; Rossi, Yanina Estefanía; Porporatto, Carina; Allemandi, Daniel Alberto; et al.; Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin; Elsevier Science; International Journal of Biological Macromolecules; 112; 13-6-2018; 399-404
0141-8130
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92601
identifier_str_mv Vanden Braber, Noelia Luciana; Paredes, Alejandro Javier; Rossi, Yanina Estefanía; Porporatto, Carina; Allemandi, Daniel Alberto; et al.; Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin; Elsevier Science; International Journal of Biological Macromolecules; 112; 13-6-2018; 399-404
0141-8130
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0141813017338667
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2018.01.085
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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