Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach

• Autores: Paquet, Maryse; Cerasuolo, Joshua O.; Thorburn, Victoria; Fridman, Sebastian; Alsubaie, Rasha; Lopes, Renato D.; Cipriano, Lauren E.; Salamone, Paula Celeste; Melling, C. W. James; Khan, Ali R.; Sedeño, Lucas; Fang, Jiming; Drangova, Maria; Montero Odasso, Manuel; Mandzia, Jennifer; Khaw, Alexander V.; Racosta, Juan M.; Paturel, Justin; Samoilov, Lucy; Stirling, Devin; Balint, Brittany; Jaremek, Victoria; Koschinsky, Marlys L.; Boffa, Michael B.; Summers, Kelly; Ibañez, Agustin Mariano; Mrkobrada, Marko; Saposnik, Gustavo; Kimpinski, Kurt; Whitehead, Shawn N.; Sposato, Luciano A.
• Año de publicación: 2018
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Atrial Fibrillation; Ischemic Stroke; Outcome; Pathophysiology; Prognosis; Recurrence
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background: It has been hypothesized that ischemic stroke can cause atrial fibrillation. By elucidating the mechanisms of neurogenically mediated paroxysmal atrial fibrillation, novel therapeutic strategies could be developed to prevent atrial fibrillation occurrence and perpetuation after stroke. This could result in fewer recurrent strokes and deaths, a reduction or delay in dementia onset, and in the lessening of the functional, structural, and metabolic consequences of atrial fibrillation on the heart. Methods: The Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE) study is an investigator-driven, translational, integrated, and transdisciplinary initiative. It comprises 3 complementary research streams that focus on atrial fibrillation detected after stroke: experimental, clinical, and epidemiological. The experimental stream will assess pre- and poststroke electrocardiographic, autonomic, anatomic (brain and heart pathology), and inflammatory trajectories in an animal model of selective insular cortex ischemic stroke. The clinical stream will prospectively investigate autonomic, inflammatory, and neurocognitive changes among patients diagnosed with atrial fibrillation detected after stroke by employing comprehensive and validated instruments. The epidemiological stream will focus on the demographics, clinical characteristics, and outcomes of atrial fibrillation detected after stroke at the population level by means of the Ontario Stroke Registry, a prospective clinical database that comprises over 23,000 patients with ischemic stroke. Conclusions: PARADISE is a translational research initiative comprising experimental, clinical, and epidemiological research aimed at characterizing clinical features, the pathophysiology, and outcomes of neurogenic atrial fibrillation detected after stroke.
Fil: Paquet, Maryse. Institute for Clinical Evaluative Sciences; Canadá
Fil: Cerasuolo, Joshua O.. Institute for Clinical Evaluative Sciences; Canadá
Fil: Thorburn, Victoria. Institute for Clinical Evaluative Sciences; Canadá
Fil: Fridman, Sebastian. Institute for Clinical Evaluative Sciences; Canadá
Fil: Alsubaie, Rasha. Institute for Clinical Evaluative Sciences; Canadá
Fil: Lopes, Renato D.. University of Duke; Estados Unidos
Fil: Cipriano, Lauren E.. Institute for Clinical Evaluative Sciences; Canadá
Fil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina
Fil: Melling, C. W. James. Institute for Clinical Evaluative Sciences; Canadá
Fil: Khan, Ali R.. Institute for Clinical Evaluative Sciences; Canadá
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina
Fil: Fang, Jiming. Institute for Clinical Evaluative Sciences; Canadá
Fil: Drangova, Maria. Western University; Canadá
Fil: Montero Odasso, Manuel. Western University; Canadá. Parkwood Institute and Lawson Health Research Institute; Canadá
Fil: Mandzia, Jennifer. Western University; Canadá
Fil: Khaw, Alexander V.. Western University; Canadá
Fil: Racosta, Juan M.. Western University; Canadá
Fil: Paturel, Justin. Western University; Canadá
Fil: Samoilov, Lucy. Western University; Canadá
Fil: Stirling, Devin. Western University; Canadá
Fil: Balint, Brittany. Western University; Canadá
Fil: Jaremek, Victoria. Western University; Canadá
Fil: Koschinsky, Marlys L.. Western University; Canadá
Fil: Boffa, Michael B.. Western University; Canadá
Fil: Summers, Kelly. Western University; Canadá
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina. Universidad Adolfo Ibañez; Chile. Universidad Autónoma del Caribe; Colombia. Australian Research Council; Australia
Fil: Mrkobrada, Marko. Western University; Canadá
Fil: Saposnik, Gustavo. University of Toronto; Canadá
Fil: Kimpinski, Kurt. Western University; Canadá
Fil: Whitehead, Shawn N.. Western University; Canadá
Fil: Sposato, Luciano A.. Western University; Canadá