Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism

Autores
Miceli, Diego Daniel; Gallelli, M. F.; Cabrera Blatter, M. F.; Martiarena, B.; Brañas, M. M.; Ortemberg, L. R.; Gómez, N. V.; Castillo, V. A.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diabetes is often associated with pituitary-dependent hyperadrenocorticism (PDH). Hypercortisolism causes insulin resistance and affects β-cell function. The purpose of this study was to test if daily administration of a long-acting insulin analogue during the first month of anti-PDH treatment can prevent progress to diabetes in these animals. Twenty-six PDH dogs were divided into three groups: one group with glycaemia <5.83 mmol/L and two groups with glycaemia >5.83 mmol/L and <9.35 mmol/L, one of which received insulin detemir during 4 months. Dogs with glycaemia <5.83 mmol/L and those with glycaemia >5.83 mmol/L which received insulin did not develop diabetes. In the non-insulin group, 6/7 dogs developed diabetes after the third month. There is a 13-fold higher risk of diabetes in dogs with glycaemia >5.83 mmol/L and no insulin treatment. Administering insulin detemir to dogs with PDH and glycaemia >5.83 mmol/L could prevent progression to diabetes.
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Gallelli, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Martiarena, B.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Brañas, M. M.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Ortemberg, L. R.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Gómez, N. V.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Castillo, V. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Materia
Pituitary Dependent Hyperadrenocorticorticism
Diabetes Mellitus
Insulin Determir
Insulin Resistence
Blood Glucose
Dogs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8454
Acceder
id CONICETDig_e31a36f676070064a1a14da7dea3a415
oai_identifier_str oai:ri.conicet.gov.ar:11336/8454
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticismMiceli, Diego DanielGallelli, M. F.Cabrera Blatter, M. F.Martiarena, B.Brañas, M. M.Ortemberg, L. R.Gómez, N. V.Castillo, V. A.Pituitary Dependent HyperadrenocorticorticismDiabetes MellitusInsulin DetermirInsulin ResistenceBlood GlucoseDogshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Diabetes is often associated with pituitary-dependent hyperadrenocorticism (PDH). Hypercortisolism causes insulin resistance and affects β-cell function. The purpose of this study was to test if daily administration of a long-acting insulin analogue during the first month of anti-PDH treatment can prevent progress to diabetes in these animals. Twenty-six PDH dogs were divided into three groups: one group with glycaemia <5.83 mmol/L and two groups with glycaemia >5.83 mmol/L and <9.35 mmol/L, one of which received insulin detemir during 4 months. Dogs with glycaemia <5.83 mmol/L and those with glycaemia >5.83 mmol/L which received insulin did not develop diabetes. In the non-insulin group, 6/7 dogs developed diabetes after the third month. There is a 13-fold higher risk of diabetes in dogs with glycaemia >5.83 mmol/L and no insulin treatment. Administering insulin detemir to dogs with PDH and glycaemia >5.83 mmol/L could prevent progression to diabetes.Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Gallelli, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Martiarena, B.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Brañas, M. M.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Ortemberg, L. R.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Gómez, N. V.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Castillo, V. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaElsevier2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8454Miceli, Diego Daniel; Gallelli, M. F.; Cabrera Blatter, M. F.; Martiarena, B.; Brañas, M. M.; et al.; Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism; Elsevier; Research In Veterinary Science; 93; 1; 8-2012; 114-1200034-52881532-2661enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2011.07.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528811002554info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:31Zoai:ri.conicet.gov.ar:11336/8454instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:32.143CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
title Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
spellingShingle Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
Miceli, Diego Daniel
Pituitary Dependent Hyperadrenocorticorticism
Diabetes Mellitus
Insulin Determir
Insulin Resistence
Blood Glucose
Dogs
title_short Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
title_full Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
title_fullStr Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
title_full_unstemmed Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
title_sort Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism
dc.creator.none.fl_str_mv Miceli, Diego Daniel
Gallelli, M. F.
Cabrera Blatter, M. F.
Martiarena, B.
Brañas, M. M.
Ortemberg, L. R.
Gómez, N. V.
Castillo, V. A.
author Miceli, Diego Daniel
author_facet Miceli, Diego Daniel
Gallelli, M. F.
Cabrera Blatter, M. F.
Martiarena, B.
Brañas, M. M.
Ortemberg, L. R.
Gómez, N. V.
Castillo, V. A.
author_role author
author2 Gallelli, M. F.
Cabrera Blatter, M. F.
Martiarena, B.
Brañas, M. M.
Ortemberg, L. R.
Gómez, N. V.
Castillo, V. A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pituitary Dependent Hyperadrenocorticorticism
Diabetes Mellitus
Insulin Determir
Insulin Resistence
Blood Glucose
Dogs
topic Pituitary Dependent Hyperadrenocorticorticism
Diabetes Mellitus
Insulin Determir
Insulin Resistence
Blood Glucose
Dogs
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Diabetes is often associated with pituitary-dependent hyperadrenocorticism (PDH). Hypercortisolism causes insulin resistance and affects β-cell function. The purpose of this study was to test if daily administration of a long-acting insulin analogue during the first month of anti-PDH treatment can prevent progress to diabetes in these animals. Twenty-six PDH dogs were divided into three groups: one group with glycaemia <5.83 mmol/L and two groups with glycaemia >5.83 mmol/L and <9.35 mmol/L, one of which received insulin detemir during 4 months. Dogs with glycaemia <5.83 mmol/L and those with glycaemia >5.83 mmol/L which received insulin did not develop diabetes. In the non-insulin group, 6/7 dogs developed diabetes after the third month. There is a 13-fold higher risk of diabetes in dogs with glycaemia >5.83 mmol/L and no insulin treatment. Administering insulin detemir to dogs with PDH and glycaemia >5.83 mmol/L could prevent progression to diabetes.
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Gallelli, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Martiarena, B.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Brañas, M. M.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Ortemberg, L. R.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Gómez, N. V.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Castillo, V. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
description Diabetes is often associated with pituitary-dependent hyperadrenocorticism (PDH). Hypercortisolism causes insulin resistance and affects β-cell function. The purpose of this study was to test if daily administration of a long-acting insulin analogue during the first month of anti-PDH treatment can prevent progress to diabetes in these animals. Twenty-six PDH dogs were divided into three groups: one group with glycaemia <5.83 mmol/L and two groups with glycaemia >5.83 mmol/L and <9.35 mmol/L, one of which received insulin detemir during 4 months. Dogs with glycaemia <5.83 mmol/L and those with glycaemia >5.83 mmol/L which received insulin did not develop diabetes. In the non-insulin group, 6/7 dogs developed diabetes after the third month. There is a 13-fold higher risk of diabetes in dogs with glycaemia >5.83 mmol/L and no insulin treatment. Administering insulin detemir to dogs with PDH and glycaemia >5.83 mmol/L could prevent progression to diabetes.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8454
Miceli, Diego Daniel; Gallelli, M. F.; Cabrera Blatter, M. F.; Martiarena, B.; Brañas, M. M.; et al.; Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism; Elsevier; Research In Veterinary Science; 93; 1; 8-2012; 114-120
0034-5288
1532-2661
url http://hdl.handle.net/11336/8454
identifier_str_mv Miceli, Diego Daniel; Gallelli, M. F.; Cabrera Blatter, M. F.; Martiarena, B.; Brañas, M. M.; et al.; Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism; Elsevier; Research In Veterinary Science; 93; 1; 8-2012; 114-120
0034-5288
1532-2661
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2011.07.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528811002554
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269407565316096
score 13.13397

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