Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
- Autores
- Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda; Pignataro, Omar Pedro; Castillo, Victor Alejandro
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC.
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Fil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina - Materia
-
Dyslipidaemia
Hyperadrenocorticism
Insulin resistance
Metformin - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/95910
Ver los metadatos del registro completo
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Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticismMiceli, Diego DanielVidal, Patricia NoemiCabrera Batter, María FernandaPignataro, Omar PedroCastillo, Victor AlejandroDyslipidaemiaHyperadrenocorticismInsulin resistanceMetforminhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC.Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; ArgentinaFil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; ArgentinaFil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; ArgentinaUniversity of Tripoli. Faculty of Veterinary Medicine2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95910Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda ; Pignataro, Omar Pedro; Castillo, Victor Alejandro; Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 2; 6-2018; 193-1992226-4485CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/172549info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987352/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:19Zoai:ri.conicet.gov.ar:11336/95910instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:20.164CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
title |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
spellingShingle |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism Miceli, Diego Daniel Dyslipidaemia Hyperadrenocorticism Insulin resistance Metformin |
title_short |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
title_full |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
title_fullStr |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
title_full_unstemmed |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
title_sort |
Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism |
dc.creator.none.fl_str_mv |
Miceli, Diego Daniel Vidal, Patricia Noemi Cabrera Batter, María Fernanda Pignataro, Omar Pedro Castillo, Victor Alejandro |
author |
Miceli, Diego Daniel |
author_facet |
Miceli, Diego Daniel Vidal, Patricia Noemi Cabrera Batter, María Fernanda Pignataro, Omar Pedro Castillo, Victor Alejandro |
author_role |
author |
author2 |
Vidal, Patricia Noemi Cabrera Batter, María Fernanda Pignataro, Omar Pedro Castillo, Victor Alejandro |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Dyslipidaemia Hyperadrenocorticism Insulin resistance Metformin |
topic |
Dyslipidaemia Hyperadrenocorticism Insulin resistance Metformin |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC. Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina Fil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina |
description |
Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/95910 Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda ; Pignataro, Omar Pedro; Castillo, Victor Alejandro; Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 2; 6-2018; 193-199 2226-4485 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/95910 |
identifier_str_mv |
Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda ; Pignataro, Omar Pedro; Castillo, Victor Alejandro; Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 2; 6-2018; 193-199 2226-4485 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/172549 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987352/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
University of Tripoli. Faculty of Veterinary Medicine |
publisher.none.fl_str_mv |
University of Tripoli. Faculty of Veterinary Medicine |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269217209974784 |
score |
13.13397 |