Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism

Autores
Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda; Pignataro, Omar Pedro; Castillo, Victor Alejandro
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC.
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Fil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Materia
Dyslipidaemia
Hyperadrenocorticism
Insulin resistance
Metformin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95910
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticismMiceli, Diego DanielVidal, Patricia NoemiCabrera Batter, María FernandaPignataro, Omar PedroCastillo, Victor AlejandroDyslipidaemiaHyperadrenocorticismInsulin resistanceMetforminhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC.Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; ArgentinaFil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; ArgentinaFil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; ArgentinaUniversity of Tripoli. Faculty of Veterinary Medicine2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95910Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda ; Pignataro, Omar Pedro; Castillo, Victor Alejandro; Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 2; 6-2018; 193-1992226-4485CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/172549info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987352/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:22Zoai:ri.conicet.gov.ar:11336/95910instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:22.282CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
title Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
spellingShingle Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
Miceli, Diego Daniel
Dyslipidaemia
Hyperadrenocorticism
Insulin resistance
Metformin
title_short Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
title_full Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
title_fullStr Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
title_full_unstemmed Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
title_sort Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
dc.creator.none.fl_str_mv Miceli, Diego Daniel
Vidal, Patricia Noemi
Cabrera Batter, María Fernanda
Pignataro, Omar Pedro
Castillo, Victor Alejandro
author Miceli, Diego Daniel
author_facet Miceli, Diego Daniel
Vidal, Patricia Noemi
Cabrera Batter, María Fernanda
Pignataro, Omar Pedro
Castillo, Victor Alejandro
author_role author
author2 Vidal, Patricia Noemi
Cabrera Batter, María Fernanda
Pignataro, Omar Pedro
Castillo, Victor Alejandro
author2_role author
author
author
author
dc.subject.none.fl_str_mv Dyslipidaemia
Hyperadrenocorticism
Insulin resistance
Metformin
topic Dyslipidaemia
Hyperadrenocorticism
Insulin resistance
Metformin
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC.
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Fil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina
description Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95910
Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda ; Pignataro, Omar Pedro; Castillo, Victor Alejandro; Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 2; 6-2018; 193-199
2226-4485
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95910
identifier_str_mv Miceli, Diego Daniel; Vidal, Patricia Noemi; Cabrera Batter, María Fernanda ; Pignataro, Omar Pedro; Castillo, Victor Alejandro; Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 2; 6-2018; 193-199
2226-4485
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/172549
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987352/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Tripoli. Faculty of Veterinary Medicine
publisher.none.fl_str_mv University of Tripoli. Faculty of Veterinary Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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