Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism

Autores
Cabrera Blatter, M. F.; Del Prado, B.; Miceli, Diego Daniel; Gomez, N.; Ivanic, J.; Di Tollo, Beatriz Andrea; Gallelli, María Florencia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, two populations of dogs with pituitary dependent hypercortisolism (PDH) were compared over a 2-year period. One group had normal vision (Group A, n = 27) and one group was blind (Group B, n = 20). Group B was characterised by the rapid appearance of the clinical signs of PDH that precede blindness. We found increases in pre-adrenocorticotropic hormone cortisol (P = 0.002), IL-6 (P = 0.0001), insulin, and insulin sensitivity (detected with the Homeostatic Model Assessment, P < 0.0001) in Group B but not in Group A. The nitric oxide (NO) and the total adiponectin concentrations decreased (P = 0.0001 and P = 0.02, respectively) in Group B versus Group A. The IL-6 and insulin concentrations and the HOMA-A index were positively correlated with the cortisol concentration and were negatively correlated with the NO concentration. With the exception of adiponectin, the other variables were associated with blindness. We concluded that blindness in PDH is a haemodynamic event associated with metabolic changes, with the increase in the IL-6 concentration and the decrease in the NO concentration affecting the retinal vasculature and producing a high risk of vision loss.
Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Del Prado, B.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gomez, N.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Ivanic, J.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Di Tollo, Beatriz Andrea. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Gallelli, María Florencia. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Materia
Il-6
Enfermedad de Cushing
Insulina
Adiponectina
Dogs
Pdh
Insulin Metabolism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25078
Acceder
id CONICETDig_6a5bf30dc25f9fde76c30d7f97e680ee
oai_identifier_str oai:ri.conicet.gov.ar:11336/25078
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticismCabrera Blatter, M. F.Del Prado, B.Miceli, Diego DanielGomez, N.Ivanic, J.Di Tollo, Beatriz AndreaGallelli, María FlorenciaIl-6Enfermedad de CushingInsulinaAdiponectinaDogsPdhInsulin Metabolismhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In this study, two populations of dogs with pituitary dependent hypercortisolism (PDH) were compared over a 2-year period. One group had normal vision (Group A, n = 27) and one group was blind (Group B, n = 20). Group B was characterised by the rapid appearance of the clinical signs of PDH that precede blindness. We found increases in pre-adrenocorticotropic hormone cortisol (P = 0.002), IL-6 (P = 0.0001), insulin, and insulin sensitivity (detected with the Homeostatic Model Assessment, P < 0.0001) in Group B but not in Group A. The nitric oxide (NO) and the total adiponectin concentrations decreased (P = 0.0001 and P = 0.02, respectively) in Group B versus Group A. The IL-6 and insulin concentrations and the HOMA-A index were positively correlated with the cortisol concentration and were negatively correlated with the NO concentration. With the exception of adiponectin, the other variables were associated with blindness. We concluded that blindness in PDH is a haemodynamic event associated with metabolic changes, with the increase in the IL-6 concentration and the decrease in the NO concentration affecting the retinal vasculature and producing a high risk of vision loss.Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; ArgentinaFil: Del Prado, B.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; ArgentinaFil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Gomez, N.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; ArgentinaFil: Ivanic, J.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; ArgentinaFil: Di Tollo, Beatriz Andrea. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; ArgentinaFil: Gallelli, María Florencia. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; ArgentinaElsevier2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25078Cabrera Blatter, M. F.; Del Prado, B.; Miceli, Diego Daniel; Gomez, N.; Ivanic, J.; et al.; Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism; Elsevier; Research in Veterinary Science; 93; 3; 8-2012; 1195-12020034-52881532-2661CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528812000665info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2012.02.003info:eu-repo/semantics/altIdentifier/pmid/22381588info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:46Zoai:ri.conicet.gov.ar:11336/25078instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:46.971CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
title Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
spellingShingle Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
Cabrera Blatter, M. F.
Il-6
Enfermedad de Cushing
Insulina
Adiponectina
Dogs
Pdh
Insulin Metabolism
title_short Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
title_full Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
title_fullStr Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
title_full_unstemmed Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
title_sort Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism
dc.creator.none.fl_str_mv Cabrera Blatter, M. F.
Del Prado, B.
Miceli, Diego Daniel
Gomez, N.
Ivanic, J.
Di Tollo, Beatriz Andrea
Gallelli, María Florencia
author Cabrera Blatter, M. F.
author_facet Cabrera Blatter, M. F.
Del Prado, B.
Miceli, Diego Daniel
Gomez, N.
Ivanic, J.
Di Tollo, Beatriz Andrea
Gallelli, María Florencia
author_role author
author2 Del Prado, B.
Miceli, Diego Daniel
Gomez, N.
Ivanic, J.
Di Tollo, Beatriz Andrea
Gallelli, María Florencia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Il-6
Enfermedad de Cushing
Insulina
Adiponectina
Dogs
Pdh
Insulin Metabolism
topic Il-6
Enfermedad de Cushing
Insulina
Adiponectina
Dogs
Pdh
Insulin Metabolism
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this study, two populations of dogs with pituitary dependent hypercortisolism (PDH) were compared over a 2-year period. One group had normal vision (Group A, n = 27) and one group was blind (Group B, n = 20). Group B was characterised by the rapid appearance of the clinical signs of PDH that precede blindness. We found increases in pre-adrenocorticotropic hormone cortisol (P = 0.002), IL-6 (P = 0.0001), insulin, and insulin sensitivity (detected with the Homeostatic Model Assessment, P < 0.0001) in Group B but not in Group A. The nitric oxide (NO) and the total adiponectin concentrations decreased (P = 0.0001 and P = 0.02, respectively) in Group B versus Group A. The IL-6 and insulin concentrations and the HOMA-A index were positively correlated with the cortisol concentration and were negatively correlated with the NO concentration. With the exception of adiponectin, the other variables were associated with blindness. We concluded that blindness in PDH is a haemodynamic event associated with metabolic changes, with the increase in the IL-6 concentration and the decrease in the NO concentration affecting the retinal vasculature and producing a high risk of vision loss.
Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Del Prado, B.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gomez, N.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Ivanic, J.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Di Tollo, Beatriz Andrea. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
Fil: Gallelli, María Florencia. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina
description In this study, two populations of dogs with pituitary dependent hypercortisolism (PDH) were compared over a 2-year period. One group had normal vision (Group A, n = 27) and one group was blind (Group B, n = 20). Group B was characterised by the rapid appearance of the clinical signs of PDH that precede blindness. We found increases in pre-adrenocorticotropic hormone cortisol (P = 0.002), IL-6 (P = 0.0001), insulin, and insulin sensitivity (detected with the Homeostatic Model Assessment, P < 0.0001) in Group B but not in Group A. The nitric oxide (NO) and the total adiponectin concentrations decreased (P = 0.0001 and P = 0.02, respectively) in Group B versus Group A. The IL-6 and insulin concentrations and the HOMA-A index were positively correlated with the cortisol concentration and were negatively correlated with the NO concentration. With the exception of adiponectin, the other variables were associated with blindness. We concluded that blindness in PDH is a haemodynamic event associated with metabolic changes, with the increase in the IL-6 concentration and the decrease in the NO concentration affecting the retinal vasculature and producing a high risk of vision loss.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25078
Cabrera Blatter, M. F.; Del Prado, B.; Miceli, Diego Daniel; Gomez, N.; Ivanic, J.; et al.; Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism; Elsevier; Research in Veterinary Science; 93; 3; 8-2012; 1195-1202
0034-5288
1532-2661
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25078
identifier_str_mv Cabrera Blatter, M. F.; Del Prado, B.; Miceli, Diego Daniel; Gomez, N.; Ivanic, J.; et al.; Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism; Elsevier; Research in Veterinary Science; 93; 3; 8-2012; 1195-1202
0034-5288
1532-2661
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528812000665
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2012.02.003
info:eu-repo/semantics/altIdentifier/pmid/22381588
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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