Sphingolipids as critical players in retinal physiology and pathology

Autores
Simon, Maria Victoria; Basu, Sandip K.; Qaladize, Bano; Grambergs, Richards; Rotstein, Nora Patricia; Mandal, Nawajes .A.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sphingolipids have emerged as bioactive lipids involved in the regulation of many physiological and pathological processes. In the retina, they have been established toparticipate in numerousprocesses, suchas neuronal survival and death, proliferation and migration of neuronal and vascular cells, inflammation, and neovascularization. Dysregulation of sphingolipids is therefore crucial in the onset and progression of retinal diseases. This review examines the involvement of sphingolipids in retinal physiology and diseases. Ceramide (Cer) has emerged as a common mediator of inflammation and death of neuronal and retinal pigment epithelium cells in animal models of retinopathies such as glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa. Sphingosine- 1-phosphate (S1P) has opposite roles, preventing photoreceptor and ganglion cell degeneration but also promoting inflammation, fibrosis, and neovascularization in AMD, glaucoma, and pro-fibrotic disorders. Alterations in Cer, S1P, and ceramide 1- phosphate may also contribute to uveitis. Notably, use of inhibitors that either prevent Cer increase or modulate S1P signaling, such as Myriocin, desipramine, and Fingolimod (FTY720), preserves neuronal viability and retinal function. These findings underscore the relevance of alterations in the sphingolipid metabolic network in the etiology of multiple retinopathies and highlight the potential of modulating their metabolism for the design of novel therapeutic approaches.
Fil: Simon, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Basu, Sandip K.. University of Tennessee; Estados Unidos
Fil: Qaladize, Bano. University of Tennessee; Estados Unidos
Fil: Grambergs, Richards. University of Tennessee; Estados Unidos
Fil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Mandal, Nawajes .A.. University of Tennessee; Estados Unidos
Materia
AGE-RELATED MACULAR DEGENERATION
CERAMIDE
CERAMIDE-1-PHOSPHATE
PHOTORECEPTOR DEGENERATION
RETINITIS PIGMENTOSA
SPHINGOSINE-1-PHOSPHATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150731
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/150731
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sphingolipids as critical players in retinal physiology and pathologySimon, Maria VictoriaBasu, Sandip K.Qaladize, BanoGrambergs, RichardsRotstein, Nora PatriciaMandal, Nawajes .A.AGE-RELATED MACULAR DEGENERATIONCERAMIDECERAMIDE-1-PHOSPHATEPHOTORECEPTOR DEGENERATIONRETINITIS PIGMENTOSASPHINGOSINE-1-PHOSPHATEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Sphingolipids have emerged as bioactive lipids involved in the regulation of many physiological and pathological processes. In the retina, they have been established toparticipate in numerousprocesses, suchas neuronal survival and death, proliferation and migration of neuronal and vascular cells, inflammation, and neovascularization. Dysregulation of sphingolipids is therefore crucial in the onset and progression of retinal diseases. This review examines the involvement of sphingolipids in retinal physiology and diseases. Ceramide (Cer) has emerged as a common mediator of inflammation and death of neuronal and retinal pigment epithelium cells in animal models of retinopathies such as glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa. Sphingosine- 1-phosphate (S1P) has opposite roles, preventing photoreceptor and ganglion cell degeneration but also promoting inflammation, fibrosis, and neovascularization in AMD, glaucoma, and pro-fibrotic disorders. Alterations in Cer, S1P, and ceramide 1- phosphate may also contribute to uveitis. Notably, use of inhibitors that either prevent Cer increase or modulate S1P signaling, such as Myriocin, desipramine, and Fingolimod (FTY720), preserves neuronal viability and retinal function. These findings underscore the relevance of alterations in the sphingolipid metabolic network in the etiology of multiple retinopathies and highlight the potential of modulating their metabolism for the design of novel therapeutic approaches.Fil: Simon, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Basu, Sandip K.. University of Tennessee; Estados UnidosFil: Qaladize, Bano. University of Tennessee; Estados UnidosFil: Grambergs, Richards. University of Tennessee; Estados UnidosFil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Mandal, Nawajes .A.. University of Tennessee; Estados UnidosAmerican Society for Biochemistry and Molecular Biology2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150731Simon, Maria Victoria; Basu, Sandip K.; Qaladize, Bano; Grambergs, Richards; Rotstein, Nora Patricia; et al.; Sphingolipids as critical players in retinal physiology and pathology; American Society for Biochemistry and Molecular Biology; Journal of Lipid Research Papers In Press; 62; 1-2021; 1-260022-22751539-7262CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1194/jlr.TR120000972info:eu-repo/semantics/altIdentifier/url/https://www.jlr.org/article/S0022-2275(21)00017-1/fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:22:11Zoai:ri.conicet.gov.ar:11336/150731instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:22:11.728CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sphingolipids as critical players in retinal physiology and pathology
title Sphingolipids as critical players in retinal physiology and pathology
spellingShingle Sphingolipids as critical players in retinal physiology and pathology
Simon, Maria Victoria
AGE-RELATED MACULAR DEGENERATION
CERAMIDE
CERAMIDE-1-PHOSPHATE
PHOTORECEPTOR DEGENERATION
RETINITIS PIGMENTOSA
SPHINGOSINE-1-PHOSPHATE
title_short Sphingolipids as critical players in retinal physiology and pathology
title_full Sphingolipids as critical players in retinal physiology and pathology
title_fullStr Sphingolipids as critical players in retinal physiology and pathology
title_full_unstemmed Sphingolipids as critical players in retinal physiology and pathology
title_sort Sphingolipids as critical players in retinal physiology and pathology
dc.creator.none.fl_str_mv Simon, Maria Victoria
Basu, Sandip K.
Qaladize, Bano
Grambergs, Richards
Rotstein, Nora Patricia
Mandal, Nawajes .A.
author Simon, Maria Victoria
author_facet Simon, Maria Victoria
Basu, Sandip K.
Qaladize, Bano
Grambergs, Richards
Rotstein, Nora Patricia
Mandal, Nawajes .A.
author_role author
author2 Basu, Sandip K.
Qaladize, Bano
Grambergs, Richards
Rotstein, Nora Patricia
Mandal, Nawajes .A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AGE-RELATED MACULAR DEGENERATION
CERAMIDE
CERAMIDE-1-PHOSPHATE
PHOTORECEPTOR DEGENERATION
RETINITIS PIGMENTOSA
SPHINGOSINE-1-PHOSPHATE
topic AGE-RELATED MACULAR DEGENERATION
CERAMIDE
CERAMIDE-1-PHOSPHATE
PHOTORECEPTOR DEGENERATION
RETINITIS PIGMENTOSA
SPHINGOSINE-1-PHOSPHATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Sphingolipids have emerged as bioactive lipids involved in the regulation of many physiological and pathological processes. In the retina, they have been established toparticipate in numerousprocesses, suchas neuronal survival and death, proliferation and migration of neuronal and vascular cells, inflammation, and neovascularization. Dysregulation of sphingolipids is therefore crucial in the onset and progression of retinal diseases. This review examines the involvement of sphingolipids in retinal physiology and diseases. Ceramide (Cer) has emerged as a common mediator of inflammation and death of neuronal and retinal pigment epithelium cells in animal models of retinopathies such as glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa. Sphingosine- 1-phosphate (S1P) has opposite roles, preventing photoreceptor and ganglion cell degeneration but also promoting inflammation, fibrosis, and neovascularization in AMD, glaucoma, and pro-fibrotic disorders. Alterations in Cer, S1P, and ceramide 1- phosphate may also contribute to uveitis. Notably, use of inhibitors that either prevent Cer increase or modulate S1P signaling, such as Myriocin, desipramine, and Fingolimod (FTY720), preserves neuronal viability and retinal function. These findings underscore the relevance of alterations in the sphingolipid metabolic network in the etiology of multiple retinopathies and highlight the potential of modulating their metabolism for the design of novel therapeutic approaches.
Fil: Simon, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Basu, Sandip K.. University of Tennessee; Estados Unidos
Fil: Qaladize, Bano. University of Tennessee; Estados Unidos
Fil: Grambergs, Richards. University of Tennessee; Estados Unidos
Fil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Mandal, Nawajes .A.. University of Tennessee; Estados Unidos
description Sphingolipids have emerged as bioactive lipids involved in the regulation of many physiological and pathological processes. In the retina, they have been established toparticipate in numerousprocesses, suchas neuronal survival and death, proliferation and migration of neuronal and vascular cells, inflammation, and neovascularization. Dysregulation of sphingolipids is therefore crucial in the onset and progression of retinal diseases. This review examines the involvement of sphingolipids in retinal physiology and diseases. Ceramide (Cer) has emerged as a common mediator of inflammation and death of neuronal and retinal pigment epithelium cells in animal models of retinopathies such as glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa. Sphingosine- 1-phosphate (S1P) has opposite roles, preventing photoreceptor and ganglion cell degeneration but also promoting inflammation, fibrosis, and neovascularization in AMD, glaucoma, and pro-fibrotic disorders. Alterations in Cer, S1P, and ceramide 1- phosphate may also contribute to uveitis. Notably, use of inhibitors that either prevent Cer increase or modulate S1P signaling, such as Myriocin, desipramine, and Fingolimod (FTY720), preserves neuronal viability and retinal function. These findings underscore the relevance of alterations in the sphingolipid metabolic network in the etiology of multiple retinopathies and highlight the potential of modulating their metabolism for the design of novel therapeutic approaches.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150731
Simon, Maria Victoria; Basu, Sandip K.; Qaladize, Bano; Grambergs, Richards; Rotstein, Nora Patricia; et al.; Sphingolipids as critical players in retinal physiology and pathology; American Society for Biochemistry and Molecular Biology; Journal of Lipid Research Papers In Press; 62; 1-2021; 1-26
0022-2275
1539-7262
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150731
identifier_str_mv Simon, Maria Victoria; Basu, Sandip K.; Qaladize, Bano; Grambergs, Richards; Rotstein, Nora Patricia; et al.; Sphingolipids as critical players in retinal physiology and pathology; American Society for Biochemistry and Molecular Biology; Journal of Lipid Research Papers In Press; 62; 1-2021; 1-26
0022-2275
1539-7262
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1194/jlr.TR120000972
info:eu-repo/semantics/altIdentifier/url/https://www.jlr.org/article/S0022-2275(21)00017-1/fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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