Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium

Autores
Mateos, Melina Valeria; Tenconi, Paula Estefania; Giusto, Norma Maria; Salvador, Gabriela Alejandra
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The retinal pigment epithelium (RPE) is essential for the integrity and function of the retina. RPE cells exert key functions to maintain photoreceptors´ (PRs) viability and functionality, such as light absorption and protection against photo-oxidation, phagocytosis of photoreceptor outer segments (POS), transport of nutrients and water, secretion of several growth factors and reisomerization of all-trans-retinal. The RPE is also part of the outer blood-retinal barrier (BRB) and can secrete immunomodulatory molecules. This review summarizes signaling events elicited in RPE cells under stress conditions, such as bacterial endophthalmitis, hyperglycemia and oxidative stress (OS). Inflammation and OS participate in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD),diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Elucidating the molecular events involved in the inflammatory process in the RPE could thus lead to the discovery of new therapeutic targets for the treatment of retinal degenerative diseases. RPE response to inflammatory situations can mediate retinal damage or survival depending on the inflammatory context and stress duration. Independently of the nature of the stress inductor, intracellular events involved in RPE cell damage could be postulated as therapeutic targets for the treatment of ocular inflammatory diseases, among them: extracellular signal-regulated kinase (ERK) as well as the nuclear transcription factor-κB (NF-κB) activation and increased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
Fil: Mateos, Melina Valeria. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Tenconi, Paula Estefania. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Giusto, Norma Maria. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Salvador, Gabriela Alejandra. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Materia
RETINAL PIGMENT EPITHELIUM
INFLAMMATION
OXIDATIVE STRESS
DIABETIC RETINOPATHY
AGE RELATED MACULAR DEGENERATION
LYPOPOLYSACCHARIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4542
Acceder
id CONICETDig_b284e5ea193062dd41eb95fcb5f050b1
oai_identifier_str oai:ri.conicet.gov.ar:11336/4542
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epitheliumMateos, Melina ValeriaTenconi, Paula EstefaniaGiusto, Norma MariaSalvador, Gabriela AlejandraRETINAL PIGMENT EPITHELIUMINFLAMMATIONOXIDATIVE STRESSDIABETIC RETINOPATHYAGE RELATED MACULAR DEGENERATIONLYPOPOLYSACCHARIDEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The retinal pigment epithelium (RPE) is essential for the integrity and function of the retina. RPE cells exert key functions to maintain photoreceptors´ (PRs) viability and functionality, such as light absorption and protection against photo-oxidation, phagocytosis of photoreceptor outer segments (POS), transport of nutrients and water, secretion of several growth factors and reisomerization of all-trans-retinal. The RPE is also part of the outer blood-retinal barrier (BRB) and can secrete immunomodulatory molecules. This review summarizes signaling events elicited in RPE cells under stress conditions, such as bacterial endophthalmitis, hyperglycemia and oxidative stress (OS). Inflammation and OS participate in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD),diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Elucidating the molecular events involved in the inflammatory process in the RPE could thus lead to the discovery of new therapeutic targets for the treatment of retinal degenerative diseases. RPE response to inflammatory situations can mediate retinal damage or survival depending on the inflammatory context and stress duration. Independently of the nature of the stress inductor, intracellular events involved in RPE cell damage could be postulated as therapeutic targets for the treatment of ocular inflammatory diseases, among them: extracellular signal-regulated kinase (ERK) as well as the nuclear transcription factor-κB (NF-κB) activation and increased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.Fil: Mateos, Melina Valeria. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); ArgentinaFil: Tenconi, Paula Estefania. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); ArgentinaFil: Giusto, Norma Maria. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); ArgentinaFil: Salvador, Gabriela Alejandra. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); ArgentinaClinMed International Library2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4542Mateos, Melina Valeria; Tenconi, Paula Estefania; Giusto, Norma Maria; Salvador, Gabriela Alejandra; Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium; ClinMed International Library; International Journal of Ophthalmology and Clinical Research; 2; 3; 8-2015; 1-72378-346Xenginfo:eu-repo/semantics/altIdentifier/url/http://clinmedjournals.org/articles/ijocr/international-journal-of-ophthalmology-and-clinical-research-ijocr-2-033.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:44Zoai:ri.conicet.gov.ar:11336/4542instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:44.282CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
title Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
spellingShingle Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
Mateos, Melina Valeria
RETINAL PIGMENT EPITHELIUM
INFLAMMATION
OXIDATIVE STRESS
DIABETIC RETINOPATHY
AGE RELATED MACULAR DEGENERATION
LYPOPOLYSACCHARIDE
title_short Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
title_full Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
title_fullStr Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
title_full_unstemmed Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
title_sort Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
dc.creator.none.fl_str_mv Mateos, Melina Valeria
Tenconi, Paula Estefania
Giusto, Norma Maria
Salvador, Gabriela Alejandra
author Mateos, Melina Valeria
author_facet Mateos, Melina Valeria
Tenconi, Paula Estefania
Giusto, Norma Maria
Salvador, Gabriela Alejandra
author_role author
author2 Tenconi, Paula Estefania
Giusto, Norma Maria
Salvador, Gabriela Alejandra
author2_role author
author
author
dc.subject.none.fl_str_mv RETINAL PIGMENT EPITHELIUM
INFLAMMATION
OXIDATIVE STRESS
DIABETIC RETINOPATHY
AGE RELATED MACULAR DEGENERATION
LYPOPOLYSACCHARIDE
topic RETINAL PIGMENT EPITHELIUM
INFLAMMATION
OXIDATIVE STRESS
DIABETIC RETINOPATHY
AGE RELATED MACULAR DEGENERATION
LYPOPOLYSACCHARIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The retinal pigment epithelium (RPE) is essential for the integrity and function of the retina. RPE cells exert key functions to maintain photoreceptors´ (PRs) viability and functionality, such as light absorption and protection against photo-oxidation, phagocytosis of photoreceptor outer segments (POS), transport of nutrients and water, secretion of several growth factors and reisomerization of all-trans-retinal. The RPE is also part of the outer blood-retinal barrier (BRB) and can secrete immunomodulatory molecules. This review summarizes signaling events elicited in RPE cells under stress conditions, such as bacterial endophthalmitis, hyperglycemia and oxidative stress (OS). Inflammation and OS participate in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD),diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Elucidating the molecular events involved in the inflammatory process in the RPE could thus lead to the discovery of new therapeutic targets for the treatment of retinal degenerative diseases. RPE response to inflammatory situations can mediate retinal damage or survival depending on the inflammatory context and stress duration. Independently of the nature of the stress inductor, intracellular events involved in RPE cell damage could be postulated as therapeutic targets for the treatment of ocular inflammatory diseases, among them: extracellular signal-regulated kinase (ERK) as well as the nuclear transcription factor-κB (NF-κB) activation and increased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
Fil: Mateos, Melina Valeria. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Tenconi, Paula Estefania. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Giusto, Norma Maria. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Salvador, Gabriela Alejandra. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
description The retinal pigment epithelium (RPE) is essential for the integrity and function of the retina. RPE cells exert key functions to maintain photoreceptors´ (PRs) viability and functionality, such as light absorption and protection against photo-oxidation, phagocytosis of photoreceptor outer segments (POS), transport of nutrients and water, secretion of several growth factors and reisomerization of all-trans-retinal. The RPE is also part of the outer blood-retinal barrier (BRB) and can secrete immunomodulatory molecules. This review summarizes signaling events elicited in RPE cells under stress conditions, such as bacterial endophthalmitis, hyperglycemia and oxidative stress (OS). Inflammation and OS participate in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD),diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Elucidating the molecular events involved in the inflammatory process in the RPE could thus lead to the discovery of new therapeutic targets for the treatment of retinal degenerative diseases. RPE response to inflammatory situations can mediate retinal damage or survival depending on the inflammatory context and stress duration. Independently of the nature of the stress inductor, intracellular events involved in RPE cell damage could be postulated as therapeutic targets for the treatment of ocular inflammatory diseases, among them: extracellular signal-regulated kinase (ERK) as well as the nuclear transcription factor-κB (NF-κB) activation and increased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4542
Mateos, Melina Valeria; Tenconi, Paula Estefania; Giusto, Norma Maria; Salvador, Gabriela Alejandra; Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium; ClinMed International Library; International Journal of Ophthalmology and Clinical Research; 2; 3; 8-2015; 1-7
2378-346X
url http://hdl.handle.net/11336/4542
identifier_str_mv Mateos, Melina Valeria; Tenconi, Paula Estefania; Giusto, Norma Maria; Salvador, Gabriela Alejandra; Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium; ClinMed International Library; International Journal of Ophthalmology and Clinical Research; 2; 3; 8-2015; 1-7
2378-346X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://clinmedjournals.org/articles/ijocr/international-journal-of-ophthalmology-and-clinical-research-ijocr-2-033.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ClinMed International Library
publisher.none.fl_str_mv ClinMed International Library
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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