The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

Autores
de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia Belen; Berkov, Strahil; Font-Bardia, Mercè; Calvet, Teresa; Konrath, Eduardo Luis; Bueno, Kelly; Sachett, Liana G.; Dutilh, Julie H.; de Souza Borges, Warley; Viladomat, Francesc; Henriques, Amelia T.; Nair, Jerald J.; Zuanazzi, José Angelo S.; Bastida, Jaume
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
Fil: de Andrade, Jean Paulo. Universidad de Barcelona; España. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; Brasil
Fil: Giordani, Raquel B.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Torras-Claveria, Laura. Universidad de Barcelona; España. Universidad del Espiritu Santo; Brasil
Fil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Berkov, Strahil. Universidad de Barcelona; España. AgroBioInstitute; Bulgaria. Universidad del Espiritu Santo; Brasil
Fil: Font-Bardia, Mercè. Universidad de Barcelona; España
Fil: Calvet, Teresa. Universidade Estadual de Campinas; Brasil
Fil: Konrath, Eduardo Luis. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; Brasil
Fil: Bueno, Kelly. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Sachett, Liana G.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dutilh, Julie H.. Universidade Estadual de Campinas; Brasil. Universidad del Espiritu Santo; Brasil
Fil: de Souza Borges, Warley. Universidad del Espiritu Santo; Brasil
Fil: Viladomat, Francesc. Universidad de Barcelona; España
Fil: Henriques, Amelia T.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nair, Jerald J.. Universidad de Barcelona; España
Fil: Zuanazzi, José Angelo S.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bastida, Jaume. Universidad de Barcelona; España
Materia
Galanthamine
Gc-Ms
Hippeastrum
Sanguinine
X-Ray Crystallography
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48792
Acceder
id CONICETDig_e2b9df97ba0a29243aec4e9e75a413f3
oai_identifier_str oai:ri.conicet.gov.ar:11336/48792
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloidsde Andrade, Jean PauloGiordani, Raquel B.Torras-Claveria, LauraPigni, Natalia BelenBerkov, StrahilFont-Bardia, MercèCalvet, TeresaKonrath, Eduardo LuisBueno, KellySachett, Liana G.Dutilh, Julie H.de Souza Borges, WarleyViladomat, FrancescHenriques, Amelia T.Nair, Jerald J.Zuanazzi, José Angelo S.Bastida, JaumeGalanthamineGc-MsHippeastrumSanguinineX-Ray Crystallographyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.Fil: de Andrade, Jean Paulo. Universidad de Barcelona; España. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; BrasilFil: Giordani, Raquel B.. Universidade Federal do Rio Grande do Sul; BrasilFil: Torras-Claveria, Laura. Universidad de Barcelona; España. Universidad del Espiritu Santo; BrasilFil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Berkov, Strahil. Universidad de Barcelona; España. AgroBioInstitute; Bulgaria. Universidad del Espiritu Santo; BrasilFil: Font-Bardia, Mercè. Universidad de Barcelona; EspañaFil: Calvet, Teresa. Universidade Estadual de Campinas; BrasilFil: Konrath, Eduardo Luis. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; BrasilFil: Bueno, Kelly. Universidade Federal do Rio Grande do Sul; BrasilFil: Sachett, Liana G.. Universidade Federal do Rio Grande do Sul; BrasilFil: Dutilh, Julie H.. Universidade Estadual de Campinas; Brasil. Universidad del Espiritu Santo; BrasilFil: de Souza Borges, Warley. Universidad del Espiritu Santo; BrasilFil: Viladomat, Francesc. Universidad de Barcelona; EspañaFil: Henriques, Amelia T.. Universidade Federal do Rio Grande do Sul; BrasilFil: Nair, Jerald J.. Universidad de Barcelona; EspañaFil: Zuanazzi, José Angelo S.. Universidade Federal do Rio Grande do Sul; BrasilFil: Bastida, Jaume. Universidad de Barcelona; EspañaSpringer2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48792de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia Belen; Berkov, Strahil; et al.; The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids; Springer; Phytochemistry Reviews; 15; 1; 2-2016; 147-1601568-77671572-980XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs11101-015-9411-7info:eu-repo/semantics/altIdentifier/doi/10.1007/s11101-015-9411-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T12:53:00Zoai:ri.conicet.gov.ar:11336/48792instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 12:53:01.034CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
title The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
spellingShingle The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
de Andrade, Jean Paulo
Galanthamine
Gc-Ms
Hippeastrum
Sanguinine
X-Ray Crystallography
title_short The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
title_full The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
title_fullStr The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
title_full_unstemmed The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
title_sort The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
dc.creator.none.fl_str_mv de Andrade, Jean Paulo
Giordani, Raquel B.
Torras-Claveria, Laura
Pigni, Natalia Belen
Berkov, Strahil
Font-Bardia, Mercè
Calvet, Teresa
Konrath, Eduardo Luis
Bueno, Kelly
Sachett, Liana G.
Dutilh, Julie H.
de Souza Borges, Warley
Viladomat, Francesc
Henriques, Amelia T.
Nair, Jerald J.
Zuanazzi, José Angelo S.
Bastida, Jaume
author de Andrade, Jean Paulo
author_facet de Andrade, Jean Paulo
Giordani, Raquel B.
Torras-Claveria, Laura
Pigni, Natalia Belen
Berkov, Strahil
Font-Bardia, Mercè
Calvet, Teresa
Konrath, Eduardo Luis
Bueno, Kelly
Sachett, Liana G.
Dutilh, Julie H.
de Souza Borges, Warley
Viladomat, Francesc
Henriques, Amelia T.
Nair, Jerald J.
Zuanazzi, José Angelo S.
Bastida, Jaume
author_role author
author2 Giordani, Raquel B.
Torras-Claveria, Laura
Pigni, Natalia Belen
Berkov, Strahil
Font-Bardia, Mercè
Calvet, Teresa
Konrath, Eduardo Luis
Bueno, Kelly
Sachett, Liana G.
Dutilh, Julie H.
de Souza Borges, Warley
Viladomat, Francesc
Henriques, Amelia T.
Nair, Jerald J.
Zuanazzi, José Angelo S.
Bastida, Jaume
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Galanthamine
Gc-Ms
Hippeastrum
Sanguinine
X-Ray Crystallography
topic Galanthamine
Gc-Ms
Hippeastrum
Sanguinine
X-Ray Crystallography
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
Fil: de Andrade, Jean Paulo. Universidad de Barcelona; España. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; Brasil
Fil: Giordani, Raquel B.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Torras-Claveria, Laura. Universidad de Barcelona; España. Universidad del Espiritu Santo; Brasil
Fil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Berkov, Strahil. Universidad de Barcelona; España. AgroBioInstitute; Bulgaria. Universidad del Espiritu Santo; Brasil
Fil: Font-Bardia, Mercè. Universidad de Barcelona; España
Fil: Calvet, Teresa. Universidade Estadual de Campinas; Brasil
Fil: Konrath, Eduardo Luis. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; Brasil
Fil: Bueno, Kelly. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Sachett, Liana G.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dutilh, Julie H.. Universidade Estadual de Campinas; Brasil. Universidad del Espiritu Santo; Brasil
Fil: de Souza Borges, Warley. Universidad del Espiritu Santo; Brasil
Fil: Viladomat, Francesc. Universidad de Barcelona; España
Fil: Henriques, Amelia T.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nair, Jerald J.. Universidad de Barcelona; España
Fil: Zuanazzi, José Angelo S.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bastida, Jaume. Universidad de Barcelona; España
description Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48792
de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia Belen; Berkov, Strahil; et al.; The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids; Springer; Phytochemistry Reviews; 15; 1; 2-2016; 147-160
1568-7767
1572-980X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48792
identifier_str_mv de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia Belen; Berkov, Strahil; et al.; The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids; Springer; Phytochemistry Reviews; 15; 1; 2-2016; 147-160
1568-7767
1572-980X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs11101-015-9411-7
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11101-015-9411-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1853775278513324032
score 13.25844

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