Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes

Autores
Acosta, K.; Pigni, Natalia Belen; Oleas, N.; Bastida, J.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The plant family Amaryllidaceae presents a group of isoquinoline type alkaloids that have been subject of active research for almost 200 years and many of these compounds have been studied for diverse biomedical activities. This study has been focused on the analysis of Stenomesson aurantiacum from the Ecuadorian Andes, being one of the first studies of an Amaryllidaceae from Ecuador, where 33 Amaryllidaceae species have been described. The plant S. aurantiacum was collected in March 2013 from Cuicococha (Imbabura). The purified alkaloid extracts, of the different organs, were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). In total, 22 different Amaryllidaceae alkaloids were identified, with haemanthamine as the most abundant, found in concentrations above 15 % of the Total Ion Current (TIC) in all the organs, but higher in leaves. The next major alkaloids were tazettine in leaves, stem and flowers; and lycorine in bulb. This is an important finding, as previous, in vitro studies have shown that haemanthamine, lycorine and tazetine have antineoplastic and antiparasitic properties. We consider S. aurantiacum extracts could be useful in medical studies as these compounds may be effective treating tropical diseases such as Chagas or Malaria, as well as world-wide diseases such as cancer.
Fil: Acosta, K.. Escuela Superior Politécnica del Chimborazo; Ecuador
Fil: Pigni, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidad de Barcelona; España
Fil: Oleas, N.. Universidad Tecnologica Indoamerica.; Ecuador
Fil: Bastida, J.. Universidad de Barcelona; España
Materia
Alkaloids
Amaryllidaceae
Antineoplastic
Antiparasitic
Stenomesson Aurantiacum
Gc-Ms
Haemanthamine
Lycorine
Tazettine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33577
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33577
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andesAcosta, K.Pigni, Natalia BelenOleas, N.Bastida, J.AlkaloidsAmaryllidaceaeAntineoplasticAntiparasiticStenomesson AurantiacumGc-MsHaemanthamineLycorineTazettinehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The plant family Amaryllidaceae presents a group of isoquinoline type alkaloids that have been subject of active research for almost 200 years and many of these compounds have been studied for diverse biomedical activities. This study has been focused on the analysis of Stenomesson aurantiacum from the Ecuadorian Andes, being one of the first studies of an Amaryllidaceae from Ecuador, where 33 Amaryllidaceae species have been described. The plant S. aurantiacum was collected in March 2013 from Cuicococha (Imbabura). The purified alkaloid extracts, of the different organs, were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). In total, 22 different Amaryllidaceae alkaloids were identified, with haemanthamine as the most abundant, found in concentrations above 15 % of the Total Ion Current (TIC) in all the organs, but higher in leaves. The next major alkaloids were tazettine in leaves, stem and flowers; and lycorine in bulb. This is an important finding, as previous, in vitro studies have shown that haemanthamine, lycorine and tazetine have antineoplastic and antiparasitic properties. We consider S. aurantiacum extracts could be useful in medical studies as these compounds may be effective treating tropical diseases such as Chagas or Malaria, as well as world-wide diseases such as cancer.Fil: Acosta, K.. Escuela Superior Politécnica del Chimborazo; EcuadorFil: Pigni, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidad de Barcelona; EspañaFil: Oleas, N.. Universidad Tecnologica Indoamerica.; EcuadorFil: Bastida, J.. Universidad de Barcelona; EspañaSocietà Italo-Latinoamericana di Etnomedicina2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33577Acosta, K.; Pigni, Natalia Belen; Oleas, N.; Bastida, J.; Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes; Società Italo-Latinoamericana di Etnomedicina; Pharmacology Online; 3; 12-2014; 178-1831827-8620CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pharmacologyonline.silae.it/files/archives/2014/vol3/PhOL_2014_3_A025_Acosta_178_025.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:42Zoai:ri.conicet.gov.ar:11336/33577instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:43.094CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
title Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
spellingShingle Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
Acosta, K.
Alkaloids
Amaryllidaceae
Antineoplastic
Antiparasitic
Stenomesson Aurantiacum
Gc-Ms
Haemanthamine
Lycorine
Tazettine
title_short Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
title_full Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
title_fullStr Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
title_full_unstemmed Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
title_sort Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes
dc.creator.none.fl_str_mv Acosta, K.
Pigni, Natalia Belen
Oleas, N.
Bastida, J.
author Acosta, K.
author_facet Acosta, K.
Pigni, Natalia Belen
Oleas, N.
Bastida, J.
author_role author
author2 Pigni, Natalia Belen
Oleas, N.
Bastida, J.
author2_role author
author
author
dc.subject.none.fl_str_mv Alkaloids
Amaryllidaceae
Antineoplastic
Antiparasitic
Stenomesson Aurantiacum
Gc-Ms
Haemanthamine
Lycorine
Tazettine
topic Alkaloids
Amaryllidaceae
Antineoplastic
Antiparasitic
Stenomesson Aurantiacum
Gc-Ms
Haemanthamine
Lycorine
Tazettine
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The plant family Amaryllidaceae presents a group of isoquinoline type alkaloids that have been subject of active research for almost 200 years and many of these compounds have been studied for diverse biomedical activities. This study has been focused on the analysis of Stenomesson aurantiacum from the Ecuadorian Andes, being one of the first studies of an Amaryllidaceae from Ecuador, where 33 Amaryllidaceae species have been described. The plant S. aurantiacum was collected in March 2013 from Cuicococha (Imbabura). The purified alkaloid extracts, of the different organs, were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). In total, 22 different Amaryllidaceae alkaloids were identified, with haemanthamine as the most abundant, found in concentrations above 15 % of the Total Ion Current (TIC) in all the organs, but higher in leaves. The next major alkaloids were tazettine in leaves, stem and flowers; and lycorine in bulb. This is an important finding, as previous, in vitro studies have shown that haemanthamine, lycorine and tazetine have antineoplastic and antiparasitic properties. We consider S. aurantiacum extracts could be useful in medical studies as these compounds may be effective treating tropical diseases such as Chagas or Malaria, as well as world-wide diseases such as cancer.
Fil: Acosta, K.. Escuela Superior Politécnica del Chimborazo; Ecuador
Fil: Pigni, Natalia Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidad de Barcelona; España
Fil: Oleas, N.. Universidad Tecnologica Indoamerica.; Ecuador
Fil: Bastida, J.. Universidad de Barcelona; España
description The plant family Amaryllidaceae presents a group of isoquinoline type alkaloids that have been subject of active research for almost 200 years and many of these compounds have been studied for diverse biomedical activities. This study has been focused on the analysis of Stenomesson aurantiacum from the Ecuadorian Andes, being one of the first studies of an Amaryllidaceae from Ecuador, where 33 Amaryllidaceae species have been described. The plant S. aurantiacum was collected in March 2013 from Cuicococha (Imbabura). The purified alkaloid extracts, of the different organs, were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). In total, 22 different Amaryllidaceae alkaloids were identified, with haemanthamine as the most abundant, found in concentrations above 15 % of the Total Ion Current (TIC) in all the organs, but higher in leaves. The next major alkaloids were tazettine in leaves, stem and flowers; and lycorine in bulb. This is an important finding, as previous, in vitro studies have shown that haemanthamine, lycorine and tazetine have antineoplastic and antiparasitic properties. We consider S. aurantiacum extracts could be useful in medical studies as these compounds may be effective treating tropical diseases such as Chagas or Malaria, as well as world-wide diseases such as cancer.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33577
Acosta, K.; Pigni, Natalia Belen; Oleas, N.; Bastida, J.; Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes; Società Italo-Latinoamericana di Etnomedicina; Pharmacology Online; 3; 12-2014; 178-183
1827-8620
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33577
identifier_str_mv Acosta, K.; Pigni, Natalia Belen; Oleas, N.; Bastida, J.; Dentification of the alkaloids of stenomesson aurantiacum(kunth) herb., an amaryllidaceae species from the ecuadorian andes; Società Italo-Latinoamericana di Etnomedicina; Pharmacology Online; 3; 12-2014; 178-183
1827-8620
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pharmacologyonline.silae.it/files/archives/2014/vol3/PhOL_2014_3_A025_Acosta_178_025.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Società Italo-Latinoamericana di Etnomedicina
publisher.none.fl_str_mv Società Italo-Latinoamericana di Etnomedicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270131220119552
score 13.13397

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