Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids

Autores
Ortiz, Javier Esteban; Berkov, Strahil; Pigni, Natalia Belen; Theoduloz, Cristina; Roitman, German; Tapia, Alejandro; Bastida, Jaume; Feresin, Gabriela Egly
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops.
Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Berkov, Strahil. Universidad de Barcelona; España
Fil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Theoduloz, Cristina. Universidad de Talca; Chile
Fil: Roitman, German. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Bastida, Jaume. Universidad de Barcelona; España
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Materia
ACETYLCHOLINESTERASE INHIBITORS
ALKALOIDS
ARGENTINIAN AMARYLLIDACEAE WILD
GALANTHAMINE
LYCORINE
TAZETTINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/198703
Acceder
id CONICETDig_5d8f88132658249361ef1189d6ee4cd1
oai_identifier_str oai:ri.conicet.gov.ar:11336/198703
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloidsOrtiz, Javier EstebanBerkov, StrahilPigni, Natalia BelenTheoduloz, CristinaRoitman, GermanTapia, AlejandroBastida, JaumeFeresin, Gabriela EglyACETYLCHOLINESTERASE INHIBITORSALKALOIDSARGENTINIAN AMARYLLIDACEAE WILDGALANTHAMINELYCORINETAZETTINEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops.Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Berkov, Strahil. Universidad de Barcelona; EspañaFil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Theoduloz, Cristina. Universidad de Talca; ChileFil: Roitman, German. Universidad de Buenos Aires. Facultad de Agronomía; ArgentinaFil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Bastida, Jaume. Universidad de Barcelona; EspañaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaMolecular Diversity Preservation International2012-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/198703Ortiz, Javier Esteban; Berkov, Strahil; Pigni, Natalia Belen; Theoduloz, Cristina; Roitman, German; et al.; Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids; Molecular Diversity Preservation International; Molecules; 17; 11; 11-2012; 13473-134821420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules171113473info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/17/11/13473info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:18Zoai:ri.conicet.gov.ar:11336/198703instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:18.391CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
title Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
spellingShingle Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
Ortiz, Javier Esteban
ACETYLCHOLINESTERASE INHIBITORS
ALKALOIDS
ARGENTINIAN AMARYLLIDACEAE WILD
GALANTHAMINE
LYCORINE
TAZETTINE
title_short Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
title_full Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
title_fullStr Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
title_full_unstemmed Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
title_sort Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
dc.creator.none.fl_str_mv Ortiz, Javier Esteban
Berkov, Strahil
Pigni, Natalia Belen
Theoduloz, Cristina
Roitman, German
Tapia, Alejandro
Bastida, Jaume
Feresin, Gabriela Egly
author Ortiz, Javier Esteban
author_facet Ortiz, Javier Esteban
Berkov, Strahil
Pigni, Natalia Belen
Theoduloz, Cristina
Roitman, German
Tapia, Alejandro
Bastida, Jaume
Feresin, Gabriela Egly
author_role author
author2 Berkov, Strahil
Pigni, Natalia Belen
Theoduloz, Cristina
Roitman, German
Tapia, Alejandro
Bastida, Jaume
Feresin, Gabriela Egly
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACETYLCHOLINESTERASE INHIBITORS
ALKALOIDS
ARGENTINIAN AMARYLLIDACEAE WILD
GALANTHAMINE
LYCORINE
TAZETTINE
topic ACETYLCHOLINESTERASE INHIBITORS
ALKALOIDS
ARGENTINIAN AMARYLLIDACEAE WILD
GALANTHAMINE
LYCORINE
TAZETTINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops.
Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Berkov, Strahil. Universidad de Barcelona; España
Fil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Theoduloz, Cristina. Universidad de Talca; Chile
Fil: Roitman, German. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Bastida, Jaume. Universidad de Barcelona; España
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
description The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops.
publishDate 2012
dc.date.none.fl_str_mv 2012-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198703
Ortiz, Javier Esteban; Berkov, Strahil; Pigni, Natalia Belen; Theoduloz, Cristina; Roitman, German; et al.; Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids; Molecular Diversity Preservation International; Molecules; 17; 11; 11-2012; 13473-13482
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198703
identifier_str_mv Ortiz, Javier Esteban; Berkov, Strahil; Pigni, Natalia Belen; Theoduloz, Cristina; Roitman, German; et al.; Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids; Molecular Diversity Preservation International; Molecules; 17; 11; 11-2012; 13473-13482
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules171113473
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/17/11/13473
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268656994615296
score 13.13397

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