Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation

Autores
Berkovic, Andrea Mariela; Cantón, Lucila; Valente, Marcela; Dominguez, Maria Paula; Moriones, Lucila; Lanusse, Carlos Edmundo; Moreno Torrejon, Laura
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fipronil (FIP) is a pyrazole insecticide authorized to control ectoparasites in small animals(worldwide) and cattle (in some countries). Few approved antiparasitic compounds are available forpoultry. As consequence, the extra-label use of FIP has been described in this species to control thered mite Dermanyssus gallinae, an ectoparasite that constitutes an important health problem withhuge economic repercussions in poultry production. Since FIP and its fipronil sulfone (FIP-SO2)metabolite residue profiles in eggs after administration to laying hens have been reported, the maingoal of the current study was to investigate the FIP and the FIP- SO2 metabolite residues profiles inedible and other tissues after extra-label administration in laying hens. Hens were treated extralabelled with FIP (ECTOLINE® 1%) in feed and via topical application. Following animal welfarestandards, the hens were slaughtered at different times within a 60-day post-treatment period. Plasma,muscle, liver, kidney, fat, skin, feathers, and feces samples were collected and analysed to quantifyFIP and FIP- SO2 residues by UFLC-MS/MS. The withdrawal period was estimated by linearregression analysis of the log residual concentrations (fipronil+fipronil-SO2) measured in edibletissues vs. time of the terminal elimination phase. The Maximum Residue Limits (MRLs) establishedfor this species related to fipronil use as a pesticide were considered for the calculations. FIP and FIPSO2 residues were quantified in all tissues following both routes of administration. The FIP-SO2residues were the highest in most tissues. After oral administration, FIP was quantified mainly infeathers (maximum residue level [Cmax] of 0.24±0.16 µg/g at 9 days post-treatment [tmax]), and fat(Cmax= 0.49±0.46 µg/g; tmax= 6 days). The highest FIP-SO2 residue profiles were found in fat (Cmax=9.9±4.2 µg/g; tmax= 15 days), skin (Cmax= 1.7±0.6 µg/g; tmax= 9 days), and liver (Cmax= 1.1±0.5 µg/g;tmax= 6 days). Meanwhile, after topical administration, the highest residues were for FIP in feathers(Cmax: 17.6±5.3 µg/g) at 5 days post-treatment. High FIP-SO2 residues were also quantified in feathers(Cmax: 2.2±1.7 µg/g; tmax= 5 days), fat (Cmax: 1.8±0.8 µg/g; tmax= 15 days), and skin (Cmax: 0.44±0.1 µg/g; tmax= 15 days). Fipronil marker residue profiles following both administration methods exceeded tolerances and MRLs in poultry tissues. Fortunately, the lowest residue levels were found in the main edible tissue, the muscle (meat), in both administration methods. However, the estimated withdrawal periods were long and economically impractical. In poultry production, it is crucial to consider that laying hens reaching the end of their productive period are intended for consumption. These results show that the consumption of edible tissues from treated chickens could pose undesirable health effects. Fortunately, low concentrations were found in muscle. Future studies applying the risk analysis tool will be necessary to determine if there is a potential risk to consumers.
Fil: Berkovic, Andrea Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Valente, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
XXVII Congreso Panamericano de Ciencias Veterinarias
Montevideo
Uruguay
Colegio de Veterinarios del Uruguay
Universidad de la República. Facultad de Ciencias Veterinarias
Sociedad de Medicina Veterinaria del Uruguay
Materia
FIPRONIL
TISSUE RESIDUES
LAYING HENS
WITHDRAWAL TIME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257748
Acceder
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spelling Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimationBerkovic, Andrea MarielaCantón, LucilaValente, MarcelaDominguez, Maria PaulaMoriones, LucilaLanusse, Carlos EdmundoMoreno Torrejon, LauraFIPRONILTISSUE RESIDUESLAYING HENSWITHDRAWAL TIMEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Fipronil (FIP) is a pyrazole insecticide authorized to control ectoparasites in small animals(worldwide) and cattle (in some countries). Few approved antiparasitic compounds are available forpoultry. As consequence, the extra-label use of FIP has been described in this species to control thered mite Dermanyssus gallinae, an ectoparasite that constitutes an important health problem withhuge economic repercussions in poultry production. Since FIP and its fipronil sulfone (FIP-SO2)metabolite residue profiles in eggs after administration to laying hens have been reported, the maingoal of the current study was to investigate the FIP and the FIP- SO2 metabolite residues profiles inedible and other tissues after extra-label administration in laying hens. Hens were treated extralabelled with FIP (ECTOLINE® 1%) in feed and via topical application. Following animal welfarestandards, the hens were slaughtered at different times within a 60-day post-treatment period. Plasma,muscle, liver, kidney, fat, skin, feathers, and feces samples were collected and analysed to quantifyFIP and FIP- SO2 residues by UFLC-MS/MS. The withdrawal period was estimated by linearregression analysis of the log residual concentrations (fipronil+fipronil-SO2) measured in edibletissues vs. time of the terminal elimination phase. The Maximum Residue Limits (MRLs) establishedfor this species related to fipronil use as a pesticide were considered for the calculations. FIP and FIPSO2 residues were quantified in all tissues following both routes of administration. The FIP-SO2residues were the highest in most tissues. After oral administration, FIP was quantified mainly infeathers (maximum residue level [Cmax] of 0.24±0.16 µg/g at 9 days post-treatment [tmax]), and fat(Cmax= 0.49±0.46 µg/g; tmax= 6 days). The highest FIP-SO2 residue profiles were found in fat (Cmax=9.9±4.2 µg/g; tmax= 15 days), skin (Cmax= 1.7±0.6 µg/g; tmax= 9 days), and liver (Cmax= 1.1±0.5 µg/g;tmax= 6 days). Meanwhile, after topical administration, the highest residues were for FIP in feathers(Cmax: 17.6±5.3 µg/g) at 5 days post-treatment. High FIP-SO2 residues were also quantified in feathers(Cmax: 2.2±1.7 µg/g; tmax= 5 days), fat (Cmax: 1.8±0.8 µg/g; tmax= 15 days), and skin (Cmax: 0.44±0.1 µg/g; tmax= 15 days). Fipronil marker residue profiles following both administration methods exceeded tolerances and MRLs in poultry tissues. Fortunately, the lowest residue levels were found in the main edible tissue, the muscle (meat), in both administration methods. However, the estimated withdrawal periods were long and economically impractical. In poultry production, it is crucial to consider that laying hens reaching the end of their productive period are intended for consumption. These results show that the consumption of edible tissues from treated chickens could pose undesirable health effects. Fortunately, low concentrations were found in muscle. Future studies applying the risk analysis tool will be necessary to determine if there is a potential risk to consumers.Fil: Berkovic, Andrea Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Valente, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaXXVII Congreso Panamericano de Ciencias VeterinariasMontevideoUruguayColegio de Veterinarios del UruguayUniversidad de la República. Facultad de Ciencias VeterinariasSociedad de Medicina Veterinaria del UruguayColegio de Veterinarios del Uruguay2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257748Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation; XXVII Congreso Panamericano de Ciencias Veterinarias; Montevideo; Uruguay; 2024; 293-293CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.panvet2024.uy/_files/ugd/d0b038_3e3bd8f2500f4eba967245d820276927.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:48Zoai:ri.conicet.gov.ar:11336/257748instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:49.142CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
title Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
spellingShingle Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
Berkovic, Andrea Mariela
FIPRONIL
TISSUE RESIDUES
LAYING HENS
WITHDRAWAL TIME
title_short Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
title_full Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
title_fullStr Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
title_full_unstemmed Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
title_sort Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation
dc.creator.none.fl_str_mv Berkovic, Andrea Mariela
Cantón, Lucila
Valente, Marcela
Dominguez, Maria Paula
Moriones, Lucila
Lanusse, Carlos Edmundo
Moreno Torrejon, Laura
author Berkovic, Andrea Mariela
author_facet Berkovic, Andrea Mariela
Cantón, Lucila
Valente, Marcela
Dominguez, Maria Paula
Moriones, Lucila
Lanusse, Carlos Edmundo
Moreno Torrejon, Laura
author_role author
author2 Cantón, Lucila
Valente, Marcela
Dominguez, Maria Paula
Moriones, Lucila
Lanusse, Carlos Edmundo
Moreno Torrejon, Laura
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv FIPRONIL
TISSUE RESIDUES
LAYING HENS
WITHDRAWAL TIME
topic FIPRONIL
TISSUE RESIDUES
LAYING HENS
WITHDRAWAL TIME
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Fipronil (FIP) is a pyrazole insecticide authorized to control ectoparasites in small animals(worldwide) and cattle (in some countries). Few approved antiparasitic compounds are available forpoultry. As consequence, the extra-label use of FIP has been described in this species to control thered mite Dermanyssus gallinae, an ectoparasite that constitutes an important health problem withhuge economic repercussions in poultry production. Since FIP and its fipronil sulfone (FIP-SO2)metabolite residue profiles in eggs after administration to laying hens have been reported, the maingoal of the current study was to investigate the FIP and the FIP- SO2 metabolite residues profiles inedible and other tissues after extra-label administration in laying hens. Hens were treated extralabelled with FIP (ECTOLINE® 1%) in feed and via topical application. Following animal welfarestandards, the hens were slaughtered at different times within a 60-day post-treatment period. Plasma,muscle, liver, kidney, fat, skin, feathers, and feces samples were collected and analysed to quantifyFIP and FIP- SO2 residues by UFLC-MS/MS. The withdrawal period was estimated by linearregression analysis of the log residual concentrations (fipronil+fipronil-SO2) measured in edibletissues vs. time of the terminal elimination phase. The Maximum Residue Limits (MRLs) establishedfor this species related to fipronil use as a pesticide were considered for the calculations. FIP and FIPSO2 residues were quantified in all tissues following both routes of administration. The FIP-SO2residues were the highest in most tissues. After oral administration, FIP was quantified mainly infeathers (maximum residue level [Cmax] of 0.24±0.16 µg/g at 9 days post-treatment [tmax]), and fat(Cmax= 0.49±0.46 µg/g; tmax= 6 days). The highest FIP-SO2 residue profiles were found in fat (Cmax=9.9±4.2 µg/g; tmax= 15 days), skin (Cmax= 1.7±0.6 µg/g; tmax= 9 days), and liver (Cmax= 1.1±0.5 µg/g;tmax= 6 days). Meanwhile, after topical administration, the highest residues were for FIP in feathers(Cmax: 17.6±5.3 µg/g) at 5 days post-treatment. High FIP-SO2 residues were also quantified in feathers(Cmax: 2.2±1.7 µg/g; tmax= 5 days), fat (Cmax: 1.8±0.8 µg/g; tmax= 15 days), and skin (Cmax: 0.44±0.1 µg/g; tmax= 15 days). Fipronil marker residue profiles following both administration methods exceeded tolerances and MRLs in poultry tissues. Fortunately, the lowest residue levels were found in the main edible tissue, the muscle (meat), in both administration methods. However, the estimated withdrawal periods were long and economically impractical. In poultry production, it is crucial to consider that laying hens reaching the end of their productive period are intended for consumption. These results show that the consumption of edible tissues from treated chickens could pose undesirable health effects. Fortunately, low concentrations were found in muscle. Future studies applying the risk analysis tool will be necessary to determine if there is a potential risk to consumers.
Fil: Berkovic, Andrea Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Valente, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
XXVII Congreso Panamericano de Ciencias Veterinarias
Montevideo
Uruguay
Colegio de Veterinarios del Uruguay
Universidad de la República. Facultad de Ciencias Veterinarias
Sociedad de Medicina Veterinaria del Uruguay
description Fipronil (FIP) is a pyrazole insecticide authorized to control ectoparasites in small animals(worldwide) and cattle (in some countries). Few approved antiparasitic compounds are available forpoultry. As consequence, the extra-label use of FIP has been described in this species to control thered mite Dermanyssus gallinae, an ectoparasite that constitutes an important health problem withhuge economic repercussions in poultry production. Since FIP and its fipronil sulfone (FIP-SO2)metabolite residue profiles in eggs after administration to laying hens have been reported, the maingoal of the current study was to investigate the FIP and the FIP- SO2 metabolite residues profiles inedible and other tissues after extra-label administration in laying hens. Hens were treated extralabelled with FIP (ECTOLINE® 1%) in feed and via topical application. Following animal welfarestandards, the hens were slaughtered at different times within a 60-day post-treatment period. Plasma,muscle, liver, kidney, fat, skin, feathers, and feces samples were collected and analysed to quantifyFIP and FIP- SO2 residues by UFLC-MS/MS. The withdrawal period was estimated by linearregression analysis of the log residual concentrations (fipronil+fipronil-SO2) measured in edibletissues vs. time of the terminal elimination phase. The Maximum Residue Limits (MRLs) establishedfor this species related to fipronil use as a pesticide were considered for the calculations. FIP and FIPSO2 residues were quantified in all tissues following both routes of administration. The FIP-SO2residues were the highest in most tissues. After oral administration, FIP was quantified mainly infeathers (maximum residue level [Cmax] of 0.24±0.16 µg/g at 9 days post-treatment [tmax]), and fat(Cmax= 0.49±0.46 µg/g; tmax= 6 days). The highest FIP-SO2 residue profiles were found in fat (Cmax=9.9±4.2 µg/g; tmax= 15 days), skin (Cmax= 1.7±0.6 µg/g; tmax= 9 days), and liver (Cmax= 1.1±0.5 µg/g;tmax= 6 days). Meanwhile, after topical administration, the highest residues were for FIP in feathers(Cmax: 17.6±5.3 µg/g) at 5 days post-treatment. High FIP-SO2 residues were also quantified in feathers(Cmax: 2.2±1.7 µg/g; tmax= 5 days), fat (Cmax: 1.8±0.8 µg/g; tmax= 15 days), and skin (Cmax: 0.44±0.1 µg/g; tmax= 15 days). Fipronil marker residue profiles following both administration methods exceeded tolerances and MRLs in poultry tissues. Fortunately, the lowest residue levels were found in the main edible tissue, the muscle (meat), in both administration methods. However, the estimated withdrawal periods were long and economically impractical. In poultry production, it is crucial to consider that laying hens reaching the end of their productive period are intended for consumption. These results show that the consumption of edible tissues from treated chickens could pose undesirable health effects. Fortunately, low concentrations were found in muscle. Future studies applying the risk analysis tool will be necessary to determine if there is a potential risk to consumers.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257748
Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation; XXVII Congreso Panamericano de Ciencias Veterinarias; Montevideo; Uruguay; 2024; 293-293
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257748
identifier_str_mv Fipronil administration in laying hens: tissue residue profiles and wihtdrawal-time estimation; XXVII Congreso Panamericano de Ciencias Veterinarias; Montevideo; Uruguay; 2024; 293-293
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Colegio de Veterinarios del Uruguay
publisher.none.fl_str_mv Colegio de Veterinarios del Uruguay
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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