Drug residues assessment after extra-label use of fipronil in laying hens

Autores
Cantón, Lucila; Farias, Cristina Elena; Dominguez, Maria Paula; Ceballos, Laura; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Moreno Torrejon, Laura
Año de publicación
2018
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Introduction: Current increase on Argentine poultry production is closely linked with the need of parasite control to achieve optimal production standards. However, the availability of approved antiparasitic compounds to use in poultry is scarce. Fipronil (FIP) is an insecticide belonging to the pyrazole class. FIP is authorized to control ectoparasites in small animals and cattle in some countries. It is suspected that FIP is worldwide used in an extra-label manner in poultry farming to control ectoparasites (mainly the poultry red mite Dermanyssus gallinae). A Maximum Residue Limit (MRL) (0.02 mg/kg) has been established for this molecule (sum of FIP and its sulfone metabolite, expressed as FIP) in eggs. Objective: The goal of the current study was to investigate the FIP and the FIP-sulfone metabolite residues profiles in eggs after its extra-label administration to laying hens.Materials and methods: Hens from a local farm were extralabel treated with FIP (ECTOLINE® 1%) in feed for a week. Eggs were collected for a 36 days post-treatment period. White and yolk egg samples were processed and analysed to determine FIP and FIP-sulfone metabolite residues by HPLC with diode array detection.Results and conclusions: Drug residues did not reach measurable residual concentrations in white samples after extra-label administration of FIP to laying-hens. Residual concentrations of fipronil-sulfone (active metabolite of FIP) were found in yolk egg at levels higher than those of the established MRL value. A maximum residue level (Cmax) of 2.10±0.34 µg/g was quantified at 9 days (tmax) after the beginning of treatment. Since a withdrawal period have not been established, these data strongly suggest that extra-label use of FIP could constitute a potential risk for consumers with the consequent negative economic repercussions in poultry production.
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
14 th International Congress of the European Association for Veterinary Pharmacology and Toxicology
Wroclaw
Polonia
European Association for Veterinary Pharmacology and Toxicology
Materia
Drug residues
Fipronil
Laying hens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167663
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Drug residues assessment after extra-label use of fipronil in laying hensCantón, LucilaFarias, Cristina ElenaDominguez, Maria PaulaCeballos, LauraLanusse, Carlos EdmundoAlvarez, Luis IgnacioMoreno Torrejon, LauraDrug residuesFipronilLaying henshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Introduction: Current increase on Argentine poultry production is closely linked with the need of parasite control to achieve optimal production standards. However, the availability of approved antiparasitic compounds to use in poultry is scarce. Fipronil (FIP) is an insecticide belonging to the pyrazole class. FIP is authorized to control ectoparasites in small animals and cattle in some countries. It is suspected that FIP is worldwide used in an extra-label manner in poultry farming to control ectoparasites (mainly the poultry red mite Dermanyssus gallinae). A Maximum Residue Limit (MRL) (0.02 mg/kg) has been established for this molecule (sum of FIP and its sulfone metabolite, expressed as FIP) in eggs. Objective: The goal of the current study was to investigate the FIP and the FIP-sulfone metabolite residues profiles in eggs after its extra-label administration to laying hens.Materials and methods: Hens from a local farm were extralabel treated with FIP (ECTOLINE® 1%) in feed for a week. Eggs were collected for a 36 days post-treatment period. White and yolk egg samples were processed and analysed to determine FIP and FIP-sulfone metabolite residues by HPLC with diode array detection.Results and conclusions: Drug residues did not reach measurable residual concentrations in white samples after extra-label administration of FIP to laying-hens. Residual concentrations of fipronil-sulfone (active metabolite of FIP) were found in yolk egg at levels higher than those of the established MRL value. A maximum residue level (Cmax) of 2.10±0.34 µg/g was quantified at 9 days (tmax) after the beginning of treatment. Since a withdrawal period have not been established, these data strongly suggest that extra-label use of FIP could constitute a potential risk for consumers with the consequent negative economic repercussions in poultry production.Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina14 th International Congress of the European Association for Veterinary Pharmacology and ToxicologyWroclawPoloniaEuropean Association for Veterinary Pharmacology and ToxicologyWiley2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167663Drug residues assessment after extra-label use of fipronil in laying hens; 14 th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Wroclaw; Polonia; 2018; 23-231365-2885CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/toc/13652885/2018/41/S1info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.12623Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:22Zoai:ri.conicet.gov.ar:11336/167663instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:22.881CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Drug residues assessment after extra-label use of fipronil in laying hens
title Drug residues assessment after extra-label use of fipronil in laying hens
spellingShingle Drug residues assessment after extra-label use of fipronil in laying hens
Cantón, Lucila
Drug residues
Fipronil
Laying hens
title_short Drug residues assessment after extra-label use of fipronil in laying hens
title_full Drug residues assessment after extra-label use of fipronil in laying hens
title_fullStr Drug residues assessment after extra-label use of fipronil in laying hens
title_full_unstemmed Drug residues assessment after extra-label use of fipronil in laying hens
title_sort Drug residues assessment after extra-label use of fipronil in laying hens
dc.creator.none.fl_str_mv Cantón, Lucila
Farias, Cristina Elena
Dominguez, Maria Paula
Ceballos, Laura
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Moreno Torrejon, Laura
author Cantón, Lucila
author_facet Cantón, Lucila
Farias, Cristina Elena
Dominguez, Maria Paula
Ceballos, Laura
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Moreno Torrejon, Laura
author_role author
author2 Farias, Cristina Elena
Dominguez, Maria Paula
Ceballos, Laura
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Moreno Torrejon, Laura
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Drug residues
Fipronil
Laying hens
topic Drug residues
Fipronil
Laying hens
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Introduction: Current increase on Argentine poultry production is closely linked with the need of parasite control to achieve optimal production standards. However, the availability of approved antiparasitic compounds to use in poultry is scarce. Fipronil (FIP) is an insecticide belonging to the pyrazole class. FIP is authorized to control ectoparasites in small animals and cattle in some countries. It is suspected that FIP is worldwide used in an extra-label manner in poultry farming to control ectoparasites (mainly the poultry red mite Dermanyssus gallinae). A Maximum Residue Limit (MRL) (0.02 mg/kg) has been established for this molecule (sum of FIP and its sulfone metabolite, expressed as FIP) in eggs. Objective: The goal of the current study was to investigate the FIP and the FIP-sulfone metabolite residues profiles in eggs after its extra-label administration to laying hens.Materials and methods: Hens from a local farm were extralabel treated with FIP (ECTOLINE® 1%) in feed for a week. Eggs were collected for a 36 days post-treatment period. White and yolk egg samples were processed and analysed to determine FIP and FIP-sulfone metabolite residues by HPLC with diode array detection.Results and conclusions: Drug residues did not reach measurable residual concentrations in white samples after extra-label administration of FIP to laying-hens. Residual concentrations of fipronil-sulfone (active metabolite of FIP) were found in yolk egg at levels higher than those of the established MRL value. A maximum residue level (Cmax) of 2.10±0.34 µg/g was quantified at 9 days (tmax) after the beginning of treatment. Since a withdrawal period have not been established, these data strongly suggest that extra-label use of FIP could constitute a potential risk for consumers with the consequent negative economic repercussions in poultry production.
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
14 th International Congress of the European Association for Veterinary Pharmacology and Toxicology
Wroclaw
Polonia
European Association for Veterinary Pharmacology and Toxicology
description Introduction: Current increase on Argentine poultry production is closely linked with the need of parasite control to achieve optimal production standards. However, the availability of approved antiparasitic compounds to use in poultry is scarce. Fipronil (FIP) is an insecticide belonging to the pyrazole class. FIP is authorized to control ectoparasites in small animals and cattle in some countries. It is suspected that FIP is worldwide used in an extra-label manner in poultry farming to control ectoparasites (mainly the poultry red mite Dermanyssus gallinae). A Maximum Residue Limit (MRL) (0.02 mg/kg) has been established for this molecule (sum of FIP and its sulfone metabolite, expressed as FIP) in eggs. Objective: The goal of the current study was to investigate the FIP and the FIP-sulfone metabolite residues profiles in eggs after its extra-label administration to laying hens.Materials and methods: Hens from a local farm were extralabel treated with FIP (ECTOLINE® 1%) in feed for a week. Eggs were collected for a 36 days post-treatment period. White and yolk egg samples were processed and analysed to determine FIP and FIP-sulfone metabolite residues by HPLC with diode array detection.Results and conclusions: Drug residues did not reach measurable residual concentrations in white samples after extra-label administration of FIP to laying-hens. Residual concentrations of fipronil-sulfone (active metabolite of FIP) were found in yolk egg at levels higher than those of the established MRL value. A maximum residue level (Cmax) of 2.10±0.34 µg/g was quantified at 9 days (tmax) after the beginning of treatment. Since a withdrawal period have not been established, these data strongly suggest that extra-label use of FIP could constitute a potential risk for consumers with the consequent negative economic repercussions in poultry production.
publishDate 2018
dc.date.none.fl_str_mv 2018
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info:eu-repo/semantics/conferenceObject
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Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167663
Drug residues assessment after extra-label use of fipronil in laying hens; 14 th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Wroclaw; Polonia; 2018; 23-23
1365-2885
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167663
identifier_str_mv Drug residues assessment after extra-label use of fipronil in laying hens; 14 th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Wroclaw; Polonia; 2018; 23-23
1365-2885
CONICET Digital
CONICET
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