Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.

Autores
Rovetto, Laura Jorgelina; Aieta, Niccolo V.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cannabis sativa L. extracts with high concentration of δ9-tetrahydrocannabinolic acid (THCA) and δ9-tetrahydrocannabinol (THC) were obtained by supercritical carbon dioxide (CO2) extraction. The objective of this work was to investigate the cannabinoid concentration of the extracts, the overall process yield under different extraction conditions, and the effect of ethanol as co-solvent. Extraction experiments were carried out with multistage pressure increments and at constant pressure of 17, 24 and 34MPa and 328K with flow rate of 200g/min of CO2. At 34MPa apparent solubilities of extracts were determined for four different Cannabis sativa L. strains with variable cannabinoids initial content. Extraction yield was highly dependent on pressure and plant material starting composition. The use of ethanol as a co-solvent was investigated with two different approaches, i.e. constant co-solvent flow, and by applying pulses of ethanol at different times though the extraction procedure. The obtained extracts were fractionated in 3 separators in a cascade configuration of decreasing temperature and pressure. The cannabinoid composition of the extracts was determined with HPLC analysis. Process extraction efficiency as high as 92% was achieved.
Fil: Rovetto, Laura Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (I). Grupo Vinculado al Plapiqui - Investigación y Desarrollo en Tecnología Química; Argentina. SPHEREX; Estados Unidos
Fil: Aieta, Niccolo V.. SPHEREX; Estados Unidos
Materia
Cannabinoids
Cannabis Sativa L.
Co-Solvent
Pulse Regime
Supercritical Co2 Extraction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43849
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/43849
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.Rovetto, Laura JorgelinaAieta, Niccolo V.CannabinoidsCannabis Sativa L.Co-SolventPulse RegimeSupercritical Co2 Extractionhttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Cannabis sativa L. extracts with high concentration of δ9-tetrahydrocannabinolic acid (THCA) and δ9-tetrahydrocannabinol (THC) were obtained by supercritical carbon dioxide (CO2) extraction. The objective of this work was to investigate the cannabinoid concentration of the extracts, the overall process yield under different extraction conditions, and the effect of ethanol as co-solvent. Extraction experiments were carried out with multistage pressure increments and at constant pressure of 17, 24 and 34MPa and 328K with flow rate of 200g/min of CO2. At 34MPa apparent solubilities of extracts were determined for four different Cannabis sativa L. strains with variable cannabinoids initial content. Extraction yield was highly dependent on pressure and plant material starting composition. The use of ethanol as a co-solvent was investigated with two different approaches, i.e. constant co-solvent flow, and by applying pulses of ethanol at different times though the extraction procedure. The obtained extracts were fractionated in 3 separators in a cascade configuration of decreasing temperature and pressure. The cannabinoid composition of the extracts was determined with HPLC analysis. Process extraction efficiency as high as 92% was achieved.Fil: Rovetto, Laura Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (I). Grupo Vinculado al Plapiqui - Investigación y Desarrollo en Tecnología Química; Argentina. SPHEREX; Estados UnidosFil: Aieta, Niccolo V.. SPHEREX; Estados UnidosElsevier Science2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43849Rovetto, Laura Jorgelina; Aieta, Niccolo V.; Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.; Elsevier Science; Journal of Supercritical Fluids; 129; 11-2017; 16-270896-8446CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.supflu.2017.03.014info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0896844617301900info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:17Zoai:ri.conicet.gov.ar:11336/43849instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:17.327CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
title Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
spellingShingle Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
Rovetto, Laura Jorgelina
Cannabinoids
Cannabis Sativa L.
Co-Solvent
Pulse Regime
Supercritical Co2 Extraction
title_short Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
title_full Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
title_fullStr Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
title_full_unstemmed Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
title_sort Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.
dc.creator.none.fl_str_mv Rovetto, Laura Jorgelina
Aieta, Niccolo V.
author Rovetto, Laura Jorgelina
author_facet Rovetto, Laura Jorgelina
Aieta, Niccolo V.
author_role author
author2 Aieta, Niccolo V.
author2_role author
dc.subject.none.fl_str_mv Cannabinoids
Cannabis Sativa L.
Co-Solvent
Pulse Regime
Supercritical Co2 Extraction
topic Cannabinoids
Cannabis Sativa L.
Co-Solvent
Pulse Regime
Supercritical Co2 Extraction
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Cannabis sativa L. extracts with high concentration of δ9-tetrahydrocannabinolic acid (THCA) and δ9-tetrahydrocannabinol (THC) were obtained by supercritical carbon dioxide (CO2) extraction. The objective of this work was to investigate the cannabinoid concentration of the extracts, the overall process yield under different extraction conditions, and the effect of ethanol as co-solvent. Extraction experiments were carried out with multistage pressure increments and at constant pressure of 17, 24 and 34MPa and 328K with flow rate of 200g/min of CO2. At 34MPa apparent solubilities of extracts were determined for four different Cannabis sativa L. strains with variable cannabinoids initial content. Extraction yield was highly dependent on pressure and plant material starting composition. The use of ethanol as a co-solvent was investigated with two different approaches, i.e. constant co-solvent flow, and by applying pulses of ethanol at different times though the extraction procedure. The obtained extracts were fractionated in 3 separators in a cascade configuration of decreasing temperature and pressure. The cannabinoid composition of the extracts was determined with HPLC analysis. Process extraction efficiency as high as 92% was achieved.
Fil: Rovetto, Laura Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (I). Grupo Vinculado al Plapiqui - Investigación y Desarrollo en Tecnología Química; Argentina. SPHEREX; Estados Unidos
Fil: Aieta, Niccolo V.. SPHEREX; Estados Unidos
description Cannabis sativa L. extracts with high concentration of δ9-tetrahydrocannabinolic acid (THCA) and δ9-tetrahydrocannabinol (THC) were obtained by supercritical carbon dioxide (CO2) extraction. The objective of this work was to investigate the cannabinoid concentration of the extracts, the overall process yield under different extraction conditions, and the effect of ethanol as co-solvent. Extraction experiments were carried out with multistage pressure increments and at constant pressure of 17, 24 and 34MPa and 328K with flow rate of 200g/min of CO2. At 34MPa apparent solubilities of extracts were determined for four different Cannabis sativa L. strains with variable cannabinoids initial content. Extraction yield was highly dependent on pressure and plant material starting composition. The use of ethanol as a co-solvent was investigated with two different approaches, i.e. constant co-solvent flow, and by applying pulses of ethanol at different times though the extraction procedure. The obtained extracts were fractionated in 3 separators in a cascade configuration of decreasing temperature and pressure. The cannabinoid composition of the extracts was determined with HPLC analysis. Process extraction efficiency as high as 92% was achieved.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43849
Rovetto, Laura Jorgelina; Aieta, Niccolo V.; Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.; Elsevier Science; Journal of Supercritical Fluids; 129; 11-2017; 16-27
0896-8446
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43849
identifier_str_mv Rovetto, Laura Jorgelina; Aieta, Niccolo V.; Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.; Elsevier Science; Journal of Supercritical Fluids; 129; 11-2017; 16-27
0896-8446
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.supflu.2017.03.014
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0896844617301900
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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