Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility

Autores
Buffone, Mariano Gabriel; Ijiri, Takashi W.; Cao, Wenlei; Merdiushev, Tanya; Aghajanian, Haig K.; Gerton, George L.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their release into the lumen of the seminiferous tubules, the site of spermatogenesis in the testis. These cells require maturation in the epididymis and female reproductive tract before they become competent for fertilization. Here we review aspects of the structural and molecular mechanisms that promote forward motility, hyperactivated motility, and acrosomal exocytosis. As a result, we favor a model articulated by others that the flagellum senses external signals and communicates with the head by second messengers to affect sperm functions such as acrosomal exocytosis. We hope this conceptual framework will serve to stimulate thinking and experimental investigations concerning the various steps of activating a sperm from a quiescent state to a gamete that is fully competent and committed to fertilization. The three themes of compartmentalization, competence, and commitment are key to an understanding of the molecular mechanisms of sperm activation. Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems.
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. University of Pennsylvania; Estados Unidos
Fil: Ijiri, Takashi W.. University of Pennsylvania; Estados Unidos
Fil: Cao, Wenlei. University of Pennsylvania; Estados Unidos
Fil: Merdiushev, Tanya. University of Pennsylvania; Estados Unidos
Fil: Aghajanian, Haig K.. University of Pennsylvania; Estados Unidos
Fil: Gerton, George L.. University of Pennsylvania; Estados Unidos
Materia
SPERM
MOTILITY
ACROSOME REACTION
CAPACITATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9855
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/9855
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motilityBuffone, Mariano GabrielIjiri, Takashi W.Cao, WenleiMerdiushev, TanyaAghajanian, Haig K.Gerton, George L.SPERMMOTILITYACROSOME REACTIONCAPACITATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their release into the lumen of the seminiferous tubules, the site of spermatogenesis in the testis. These cells require maturation in the epididymis and female reproductive tract before they become competent for fertilization. Here we review aspects of the structural and molecular mechanisms that promote forward motility, hyperactivated motility, and acrosomal exocytosis. As a result, we favor a model articulated by others that the flagellum senses external signals and communicates with the head by second messengers to affect sperm functions such as acrosomal exocytosis. We hope this conceptual framework will serve to stimulate thinking and experimental investigations concerning the various steps of activating a sperm from a quiescent state to a gamete that is fully competent and committed to fertilization. The three themes of compartmentalization, competence, and commitment are key to an understanding of the molecular mechanisms of sperm activation. Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems.Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. University of Pennsylvania; Estados UnidosFil: Ijiri, Takashi W.. University of Pennsylvania; Estados UnidosFil: Cao, Wenlei. University of Pennsylvania; Estados UnidosFil: Merdiushev, Tanya. University of Pennsylvania; Estados UnidosFil: Aghajanian, Haig K.. University of Pennsylvania; Estados UnidosFil: Gerton, George L.. University of Pennsylvania; Estados UnidosWiley2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9855Buffone, Mariano Gabriel; Ijiri, Takashi W.; Cao, Wenlei; Merdiushev, Tanya; Aghajanian, Haig K.; et al.; Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility; Wiley; Molecular Reproduction and Development; 79; 1; 1-2012; 4-181040-452X1098-2795enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mrd.21393/abstractinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1002/mrd.21393info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240700/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:47Zoai:ri.conicet.gov.ar:11336/9855instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:48.002CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
title Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
spellingShingle Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
Buffone, Mariano Gabriel
SPERM
MOTILITY
ACROSOME REACTION
CAPACITATION
title_short Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
title_full Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
title_fullStr Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
title_full_unstemmed Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
title_sort Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
dc.creator.none.fl_str_mv Buffone, Mariano Gabriel
Ijiri, Takashi W.
Cao, Wenlei
Merdiushev, Tanya
Aghajanian, Haig K.
Gerton, George L.
author Buffone, Mariano Gabriel
author_facet Buffone, Mariano Gabriel
Ijiri, Takashi W.
Cao, Wenlei
Merdiushev, Tanya
Aghajanian, Haig K.
Gerton, George L.
author_role author
author2 Ijiri, Takashi W.
Cao, Wenlei
Merdiushev, Tanya
Aghajanian, Haig K.
Gerton, George L.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv SPERM
MOTILITY
ACROSOME REACTION
CAPACITATION
topic SPERM
MOTILITY
ACROSOME REACTION
CAPACITATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their release into the lumen of the seminiferous tubules, the site of spermatogenesis in the testis. These cells require maturation in the epididymis and female reproductive tract before they become competent for fertilization. Here we review aspects of the structural and molecular mechanisms that promote forward motility, hyperactivated motility, and acrosomal exocytosis. As a result, we favor a model articulated by others that the flagellum senses external signals and communicates with the head by second messengers to affect sperm functions such as acrosomal exocytosis. We hope this conceptual framework will serve to stimulate thinking and experimental investigations concerning the various steps of activating a sperm from a quiescent state to a gamete that is fully competent and committed to fertilization. The three themes of compartmentalization, competence, and commitment are key to an understanding of the molecular mechanisms of sperm activation. Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems.
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. University of Pennsylvania; Estados Unidos
Fil: Ijiri, Takashi W.. University of Pennsylvania; Estados Unidos
Fil: Cao, Wenlei. University of Pennsylvania; Estados Unidos
Fil: Merdiushev, Tanya. University of Pennsylvania; Estados Unidos
Fil: Aghajanian, Haig K.. University of Pennsylvania; Estados Unidos
Fil: Gerton, George L.. University of Pennsylvania; Estados Unidos
description Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg. Furthermore, sperm do not exhibit progressive motility and are not capable of undergoing acrosomal exocytosis immediately following their release into the lumen of the seminiferous tubules, the site of spermatogenesis in the testis. These cells require maturation in the epididymis and female reproductive tract before they become competent for fertilization. Here we review aspects of the structural and molecular mechanisms that promote forward motility, hyperactivated motility, and acrosomal exocytosis. As a result, we favor a model articulated by others that the flagellum senses external signals and communicates with the head by second messengers to affect sperm functions such as acrosomal exocytosis. We hope this conceptual framework will serve to stimulate thinking and experimental investigations concerning the various steps of activating a sperm from a quiescent state to a gamete that is fully competent and committed to fertilization. The three themes of compartmentalization, competence, and commitment are key to an understanding of the molecular mechanisms of sperm activation. Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9855
Buffone, Mariano Gabriel; Ijiri, Takashi W.; Cao, Wenlei; Merdiushev, Tanya; Aghajanian, Haig K.; et al.; Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility; Wiley; Molecular Reproduction and Development; 79; 1; 1-2012; 4-18
1040-452X
1098-2795
url http://hdl.handle.net/11336/9855
identifier_str_mv Buffone, Mariano Gabriel; Ijiri, Takashi W.; Cao, Wenlei; Merdiushev, Tanya; Aghajanian, Haig K.; et al.; Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility; Wiley; Molecular Reproduction and Development; 79; 1; 1-2012; 4-18
1040-452X
1098-2795
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mrd.21393/abstract
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1002/mrd.21393
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240700/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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