Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro

Autores
Charris, Jaime; Domínguez, José; Cordero, Mary; Orfila, Luz; Riggione, Flavia; López, Simón E.; Enriz, Ricardo Daniel; Suviere, Fernando
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimidone 10-13 were prepared in order to investigate their cytotoxicity and antimalarial activities. Some of the them showed a promising activity. The detailed synthesis, spectroscopic, computational and biological data are described.
Fil: Charris, Jaime. Universidad Central de Venezuela; Venezuela
Fil: Domínguez, José. Universidad Central de Venezuela; Venezuela
Fil: Cordero, Mary. Universidad Central de Venezuela; Venezuela
Fil: Orfila, Luz. Universidad Central de Venezuela; Venezuela
Fil: Riggione, Flavia. Universidad Central de Venezuela; Venezuela
Fil: López, Simón E.. Universidad Simon Bolivar. Departamento de Quimica.; Venezuela
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Suviere, Fernando. Universidad Nacional de San Luis. Facultad de Ciencias Físico- Matemáticas y Naturales; Argentina
Materia
Pyrido pyrimidines
Synthesis
Cytotoxic activities
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127111
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitroCharris, JaimeDomínguez, JoséCordero, MaryOrfila, LuzRiggione, FlaviaLópez, Simón E.Enriz, Ricardo DanielSuviere, FernandoPyrido pyrimidinesSynthesisCytotoxic activitieshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimidone 10-13 were prepared in order to investigate their cytotoxicity and antimalarial activities. Some of the them showed a promising activity. The detailed synthesis, spectroscopic, computational and biological data are described.Fil: Charris, Jaime. Universidad Central de Venezuela; VenezuelaFil: Domínguez, José. Universidad Central de Venezuela; VenezuelaFil: Cordero, Mary. Universidad Central de Venezuela; VenezuelaFil: Orfila, Luz. Universidad Central de Venezuela; VenezuelaFil: Riggione, Flavia. Universidad Central de Venezuela; VenezuelaFil: López, Simón E.. Universidad Simon Bolivar. Departamento de Quimica.; VenezuelaFil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Suviere, Fernando. Universidad Nacional de San Luis. Facultad de Ciencias Físico- Matemáticas y Naturales; ArgentinaDe Gruyter2000-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127111Charris, Jaime; Domínguez, José; Cordero, Mary; Orfila, Luz; Riggione, Flavia; et al.; Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro; De Gruyter; Heterocyclic Communications; 6; 6; 1-12-2000; 571-5780793-02832191-0197CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/document/doi/10.1515/HC.2000.6.6.571/htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/HC.2000.6.6.571info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:23:41Zoai:ri.conicet.gov.ar:11336/127111instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:23:42.169CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
title Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
spellingShingle Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
Charris, Jaime
Pyrido pyrimidines
Synthesis
Cytotoxic activities
title_short Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
title_full Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
title_fullStr Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
title_full_unstemmed Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
title_sort Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro
dc.creator.none.fl_str_mv Charris, Jaime
Domínguez, José
Cordero, Mary
Orfila, Luz
Riggione, Flavia
López, Simón E.
Enriz, Ricardo Daniel
Suviere, Fernando
author Charris, Jaime
author_facet Charris, Jaime
Domínguez, José
Cordero, Mary
Orfila, Luz
Riggione, Flavia
López, Simón E.
Enriz, Ricardo Daniel
Suviere, Fernando
author_role author
author2 Domínguez, José
Cordero, Mary
Orfila, Luz
Riggione, Flavia
López, Simón E.
Enriz, Ricardo Daniel
Suviere, Fernando
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pyrido pyrimidines
Synthesis
Cytotoxic activities
topic Pyrido pyrimidines
Synthesis
Cytotoxic activities
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimidone 10-13 were prepared in order to investigate their cytotoxicity and antimalarial activities. Some of the them showed a promising activity. The detailed synthesis, spectroscopic, computational and biological data are described.
Fil: Charris, Jaime. Universidad Central de Venezuela; Venezuela
Fil: Domínguez, José. Universidad Central de Venezuela; Venezuela
Fil: Cordero, Mary. Universidad Central de Venezuela; Venezuela
Fil: Orfila, Luz. Universidad Central de Venezuela; Venezuela
Fil: Riggione, Flavia. Universidad Central de Venezuela; Venezuela
Fil: López, Simón E.. Universidad Simon Bolivar. Departamento de Quimica.; Venezuela
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Suviere, Fernando. Universidad Nacional de San Luis. Facultad de Ciencias Físico- Matemáticas y Naturales; Argentina
description A series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimidone 10-13 were prepared in order to investigate their cytotoxicity and antimalarial activities. Some of the them showed a promising activity. The detailed synthesis, spectroscopic, computational and biological data are described.
publishDate 2000
dc.date.none.fl_str_mv 2000-12-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127111
Charris, Jaime; Domínguez, José; Cordero, Mary; Orfila, Luz; Riggione, Flavia; et al.; Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro; De Gruyter; Heterocyclic Communications; 6; 6; 1-12-2000; 571-578
0793-0283
2191-0197
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127111
identifier_str_mv Charris, Jaime; Domínguez, José; Cordero, Mary; Orfila, Luz; Riggione, Flavia; et al.; Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro; De Gruyter; Heterocyclic Communications; 6; 6; 1-12-2000; 571-578
0793-0283
2191-0197
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/document/doi/10.1515/HC.2000.6.6.571/html
info:eu-repo/semantics/altIdentifier/doi/10.1515/HC.2000.6.6.571
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781767757856768
score 12.982451

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