Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents

Autores
Quiroga, Jairo; Cobo, Débora; Insuasty, Braulio; Abonía, Rodrigo; Nogueras, Manuel; Cobo, Justo; Vásquez, Yelkaira; Gupta, Mahabir; Derita, Marcos Gabriel; Zacchino, Susana Alicia Stella
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl) acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Fil: Quiroga, Jairo. Universidad del Valle; Colombia
Fil: Cobo, Débora. Universidad del Valle; Colombia
Fil: Insuasty, Braulio. Universidad del Valle; Colombia
Fil: Abonía, Rodrigo. Universidad del Valle; Colombia
Fil: Nogueras, Manuel. Universidad de Jaén; España
Fil: Cobo, Justo. Universidad de Jaén; España
Fil: Vásquez, Yelkaira. Universidad de Panamá; Panamá
Fil: Gupta, Mahabir. Universidad de Panamá; Panamá
Fil: Derita, Marcos Gabriel. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Departamento de Producción Vegetal. Cátedra de Cultivos Intensivos; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Departamento de Producción Vegetal. Cátedra de Cultivos Intensivos; Argentina
Materia
2-THIENYLACETONITRILE
3-THIENY-LACETONITRILE
ANTIFUNGAL AND CYTOTOXIC ACTIVITIES
BENZALDEHYDES
THIENYLACRYLONITRILES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99810
Acceder
id CONICETDig_3bad580c250f2f6c290a01e77cd320c5
oai_identifier_str oai:ri.conicet.gov.ar:11336/99810
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agentsQuiroga, JairoCobo, DéboraInsuasty, BraulioAbonía, RodrigoNogueras, ManuelCobo, JustoVásquez, YelkairaGupta, MahabirDerita, Marcos GabrielZacchino, Susana Alicia Stella2-THIENYLACETONITRILE3-THIENY-LACETONITRILEANTIFUNGAL AND CYTOTOXIC ACTIVITIESBENZALDEHYDESTHIENYLACRYLONITRILEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl) acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.Fil: Quiroga, Jairo. Universidad del Valle; ColombiaFil: Cobo, Débora. Universidad del Valle; ColombiaFil: Insuasty, Braulio. Universidad del Valle; ColombiaFil: Abonía, Rodrigo. Universidad del Valle; ColombiaFil: Nogueras, Manuel. Universidad de Jaén; EspañaFil: Cobo, Justo. Universidad de Jaén; EspañaFil: Vásquez, Yelkaira. Universidad de Panamá; PanamáFil: Gupta, Mahabir. Universidad de Panamá; PanamáFil: Derita, Marcos Gabriel. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Departamento de Producción Vegetal. Cátedra de Cultivos Intensivos; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Departamento de Producción Vegetal. Cátedra de Cultivos Intensivos; ArgentinaWiley VCH Verlag2007-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99810Quiroga, Jairo; Cobo, Débora; Insuasty, Braulio; Abonía, Rodrigo; Nogueras, Manuel; et al.; Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents; Wiley VCH Verlag; Archiv Der Pharmazie; 340; 11; 11-2007; 603-6060365-6233CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.200700082info:eu-repo/semantics/altIdentifier/doi/10.1002/ardp.200700082info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:15:57Zoai:ri.conicet.gov.ar:11336/99810instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:15:57.74CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
title Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
spellingShingle Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
Quiroga, Jairo
2-THIENYLACETONITRILE
3-THIENY-LACETONITRILE
ANTIFUNGAL AND CYTOTOXIC ACTIVITIES
BENZALDEHYDES
THIENYLACRYLONITRILES
title_short Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
title_full Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
title_fullStr Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
title_full_unstemmed Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
title_sort Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents
dc.creator.none.fl_str_mv Quiroga, Jairo
Cobo, Débora
Insuasty, Braulio
Abonía, Rodrigo
Nogueras, Manuel
Cobo, Justo
Vásquez, Yelkaira
Gupta, Mahabir
Derita, Marcos Gabriel
Zacchino, Susana Alicia Stella
author Quiroga, Jairo
author_facet Quiroga, Jairo
Cobo, Débora
Insuasty, Braulio
Abonía, Rodrigo
Nogueras, Manuel
Cobo, Justo
Vásquez, Yelkaira
Gupta, Mahabir
Derita, Marcos Gabriel
Zacchino, Susana Alicia Stella
author_role author
author2 Cobo, Débora
Insuasty, Braulio
Abonía, Rodrigo
Nogueras, Manuel
Cobo, Justo
Vásquez, Yelkaira
Gupta, Mahabir
Derita, Marcos Gabriel
Zacchino, Susana Alicia Stella
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 2-THIENYLACETONITRILE
3-THIENY-LACETONITRILE
ANTIFUNGAL AND CYTOTOXIC ACTIVITIES
BENZALDEHYDES
THIENYLACRYLONITRILES
topic 2-THIENYLACETONITRILE
3-THIENY-LACETONITRILE
ANTIFUNGAL AND CYTOTOXIC ACTIVITIES
BENZALDEHYDES
THIENYLACRYLONITRILES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl) acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Fil: Quiroga, Jairo. Universidad del Valle; Colombia
Fil: Cobo, Débora. Universidad del Valle; Colombia
Fil: Insuasty, Braulio. Universidad del Valle; Colombia
Fil: Abonía, Rodrigo. Universidad del Valle; Colombia
Fil: Nogueras, Manuel. Universidad de Jaén; España
Fil: Cobo, Justo. Universidad de Jaén; España
Fil: Vásquez, Yelkaira. Universidad de Panamá; Panamá
Fil: Gupta, Mahabir. Universidad de Panamá; Panamá
Fil: Derita, Marcos Gabriel. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Departamento de Producción Vegetal. Cátedra de Cultivos Intensivos; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Departamento de Producción Vegetal. Cátedra de Cultivos Intensivos; Argentina
description A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl) acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
publishDate 2007
dc.date.none.fl_str_mv 2007-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99810
Quiroga, Jairo; Cobo, Débora; Insuasty, Braulio; Abonía, Rodrigo; Nogueras, Manuel; et al.; Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents; Wiley VCH Verlag; Archiv Der Pharmazie; 340; 11; 11-2007; 603-606
0365-6233
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99810
identifier_str_mv Quiroga, Jairo; Cobo, Débora; Insuasty, Braulio; Abonía, Rodrigo; Nogueras, Manuel; et al.; Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3- arylacrylonitriles as antifungal and anticancer agents; Wiley VCH Verlag; Archiv Der Pharmazie; 340; 11; 11-2007; 603-606
0365-6233
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.200700082
info:eu-repo/semantics/altIdentifier/doi/10.1002/ardp.200700082
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781600692436992
score 12.982451

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