Therapeutic effects of progesterone in animal models of neurological disorders

Autores
de Nicola, Alejandro Federico; Coronel, Maria Florencia; Garay, Laura Ines; Gargiulo Monachelli, Gisella Mariana; Gonzalez Deniselle, Maria Claudia; Gonzalez, Susana Laura; Labombarda, Maria Florencia; Meyer, Maria; Guennoun, Rachida; Schumacher, Michael
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in reproduction. In this review we first discussed progesterone effects following binding to the classical intracellular progesterone receptors A and B and several forms of membrane progesterone receptors, the modulation of intracellular signalling cascades and the interaction of progesterone reduced metabolites with neurotransmitter receptors. We next described our results involving animal models of human neuropathologies to elucidate the protective roles of progesterone. We described: (a) the protective and promyelinating effects of progesterone in experimental spinal cord injury; (b) the progesterone protective effects exerted upon motoneurons in the degenerating spinal cord of Wobbler mouse model of amyotropic lateral sclerosis; (c) the protective and anti-inflammatory effects of progesterone in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis and after lysolecithin demyelination; (d) the progesterone prevention of nociception and neuropathic pain which follow spinal cord injury; and (e) the protective effect of progesterone in experimental ischemic stroke. Whenever available, the molecular mechanisms involved in these progesterone effects were examined. The multiplicity of progesterone beneficial effects has opened new venues of research for neurological disorders. In this way, results obtained in animal models could provide the basis for novel therapeutic strategies and pre-clinical studies.
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Guennoun, Rachida. Institut National de la Santé et de la Recherche Médicale; Francia; University Paris Sud; Francia;
Fil: Schumacher, Michael. Institut National de la Santé et de la Recherche Médicale; Francia; University Paris Sud; Francia;
Materia
Progesterone
Neuroprotection
Steroid Receptors
Animal Models
Wobbler Mouse
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2219
Acceder
id CONICETDig_0e889ecfafb426a5715704a00f05f8cf
oai_identifier_str oai:ri.conicet.gov.ar:11336/2219
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Therapeutic effects of progesterone in animal models of neurological disordersde Nicola, Alejandro FedericoCoronel, Maria FlorenciaGaray, Laura InesGargiulo Monachelli, Gisella MarianaGonzalez Deniselle, Maria ClaudiaGonzalez, Susana LauraLabombarda, Maria FlorenciaMeyer, MariaGuennoun, RachidaSchumacher, MichaelProgesteroneNeuroprotectionSteroid ReceptorsAnimal ModelsWobbler Mousehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in reproduction. In this review we first discussed progesterone effects following binding to the classical intracellular progesterone receptors A and B and several forms of membrane progesterone receptors, the modulation of intracellular signalling cascades and the interaction of progesterone reduced metabolites with neurotransmitter receptors. We next described our results involving animal models of human neuropathologies to elucidate the protective roles of progesterone. We described: (a) the protective and promyelinating effects of progesterone in experimental spinal cord injury; (b) the progesterone protective effects exerted upon motoneurons in the degenerating spinal cord of Wobbler mouse model of amyotropic lateral sclerosis; (c) the protective and anti-inflammatory effects of progesterone in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis and after lysolecithin demyelination; (d) the progesterone prevention of nociception and neuropathic pain which follow spinal cord injury; and (e) the protective effect of progesterone in experimental ischemic stroke. Whenever available, the molecular mechanisms involved in these progesterone effects were examined. The multiplicity of progesterone beneficial effects has opened new venues of research for neurological disorders. In this way, results obtained in animal models could provide the basis for novel therapeutic strategies and pre-clinical studies.Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;Fil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;Fil: Guennoun, Rachida. Institut National de la Santé et de la Recherche Médicale; Francia; University Paris Sud; Francia;Fil: Schumacher, Michael. Institut National de la Santé et de la Recherche Médicale; Francia; University Paris Sud; Francia;Bentham Science Publishers2013-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2219de Nicola, Alejandro Federico; Coronel, Maria Florencia; Garay, Laura Ines; Gargiulo Monachelli, Gisella Mariana; Gonzalez Deniselle, Maria Claudia; et al.; Therapeutic effects of progesterone in animal models of neurological disorders; Bentham Science Publishers; Cns & Neurological Disorders-drug Targets; 12; 8; 29-11-2013; 1205-12181871-52731996-3181enginfo:eu-repo/semantics/altIdentifier/doi/10.2174/187152731131200120info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/115009/articleinfo:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/cns-and-neurological-disorders-drug-targets/volume/12/issue/8/page/1205/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:01:20Zoai:ri.conicet.gov.ar:11336/2219instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:01:20.574CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Therapeutic effects of progesterone in animal models of neurological disorders
title Therapeutic effects of progesterone in animal models of neurological disorders
spellingShingle Therapeutic effects of progesterone in animal models of neurological disorders
de Nicola, Alejandro Federico
Progesterone
Neuroprotection
Steroid Receptors
Animal Models
Wobbler Mouse
title_short Therapeutic effects of progesterone in animal models of neurological disorders
title_full Therapeutic effects of progesterone in animal models of neurological disorders
title_fullStr Therapeutic effects of progesterone in animal models of neurological disorders
title_full_unstemmed Therapeutic effects of progesterone in animal models of neurological disorders
title_sort Therapeutic effects of progesterone in animal models of neurological disorders
dc.creator.none.fl_str_mv de Nicola, Alejandro Federico
Coronel, Maria Florencia
Garay, Laura Ines
Gargiulo Monachelli, Gisella Mariana
Gonzalez Deniselle, Maria Claudia
Gonzalez, Susana Laura
Labombarda, Maria Florencia
Meyer, Maria
Guennoun, Rachida
Schumacher, Michael
author de Nicola, Alejandro Federico
author_facet de Nicola, Alejandro Federico
Coronel, Maria Florencia
Garay, Laura Ines
Gargiulo Monachelli, Gisella Mariana
Gonzalez Deniselle, Maria Claudia
Gonzalez, Susana Laura
Labombarda, Maria Florencia
Meyer, Maria
Guennoun, Rachida
Schumacher, Michael
author_role author
author2 Coronel, Maria Florencia
Garay, Laura Ines
Gargiulo Monachelli, Gisella Mariana
Gonzalez Deniselle, Maria Claudia
Gonzalez, Susana Laura
Labombarda, Maria Florencia
Meyer, Maria
Guennoun, Rachida
Schumacher, Michael
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Progesterone
Neuroprotection
Steroid Receptors
Animal Models
Wobbler Mouse
topic Progesterone
Neuroprotection
Steroid Receptors
Animal Models
Wobbler Mouse
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in reproduction. In this review we first discussed progesterone effects following binding to the classical intracellular progesterone receptors A and B and several forms of membrane progesterone receptors, the modulation of intracellular signalling cascades and the interaction of progesterone reduced metabolites with neurotransmitter receptors. We next described our results involving animal models of human neuropathologies to elucidate the protective roles of progesterone. We described: (a) the protective and promyelinating effects of progesterone in experimental spinal cord injury; (b) the progesterone protective effects exerted upon motoneurons in the degenerating spinal cord of Wobbler mouse model of amyotropic lateral sclerosis; (c) the protective and anti-inflammatory effects of progesterone in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis and after lysolecithin demyelination; (d) the progesterone prevention of nociception and neuropathic pain which follow spinal cord injury; and (e) the protective effect of progesterone in experimental ischemic stroke. Whenever available, the molecular mechanisms involved in these progesterone effects were examined. The multiplicity of progesterone beneficial effects has opened new venues of research for neurological disorders. In this way, results obtained in animal models could provide the basis for novel therapeutic strategies and pre-clinical studies.
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina;
Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Guennoun, Rachida. Institut National de la Santé et de la Recherche Médicale; Francia; University Paris Sud; Francia;
Fil: Schumacher, Michael. Institut National de la Santé et de la Recherche Médicale; Francia; University Paris Sud; Francia;
description Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in reproduction. In this review we first discussed progesterone effects following binding to the classical intracellular progesterone receptors A and B and several forms of membrane progesterone receptors, the modulation of intracellular signalling cascades and the interaction of progesterone reduced metabolites with neurotransmitter receptors. We next described our results involving animal models of human neuropathologies to elucidate the protective roles of progesterone. We described: (a) the protective and promyelinating effects of progesterone in experimental spinal cord injury; (b) the progesterone protective effects exerted upon motoneurons in the degenerating spinal cord of Wobbler mouse model of amyotropic lateral sclerosis; (c) the protective and anti-inflammatory effects of progesterone in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis and after lysolecithin demyelination; (d) the progesterone prevention of nociception and neuropathic pain which follow spinal cord injury; and (e) the protective effect of progesterone in experimental ischemic stroke. Whenever available, the molecular mechanisms involved in these progesterone effects were examined. The multiplicity of progesterone beneficial effects has opened new venues of research for neurological disorders. In this way, results obtained in animal models could provide the basis for novel therapeutic strategies and pre-clinical studies.
publishDate 2013
dc.date.none.fl_str_mv 2013-11-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2219
de Nicola, Alejandro Federico; Coronel, Maria Florencia; Garay, Laura Ines; Gargiulo Monachelli, Gisella Mariana; Gonzalez Deniselle, Maria Claudia; et al.; Therapeutic effects of progesterone in animal models of neurological disorders; Bentham Science Publishers; Cns & Neurological Disorders-drug Targets; 12; 8; 29-11-2013; 1205-1218
1871-5273
1996-3181
url http://hdl.handle.net/11336/2219
identifier_str_mv de Nicola, Alejandro Federico; Coronel, Maria Florencia; Garay, Laura Ines; Gargiulo Monachelli, Gisella Mariana; Gonzalez Deniselle, Maria Claudia; et al.; Therapeutic effects of progesterone in animal models of neurological disorders; Bentham Science Publishers; Cns & Neurological Disorders-drug Targets; 12; 8; 29-11-2013; 1205-1218
1871-5273
1996-3181
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/187152731131200120
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/115009/article
info:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/cns-and-neurological-disorders-drug-targets/volume/12/issue/8/page/1205/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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