Progesterone and progestins: neuroprotection and myelin repair

Autores
Schumacher, Michael; Sitruk Ware, Regine; de Nicola, Alejandro Federico
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. This concept has recently been translated into clinical practice, though there is need for more experimental studies and investigations on the mechanisms of the actions of progesterone. However, it is important to be aware that most of the experimental research concerns the effects of physiological progesterone. Although progesterone represents an interesting therapeutic option, the recognition of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (HRTs).
Fil: Schumacher, Michael. Inserm; Francia
Fil: Sitruk Ware, Regine. The Rockefeller University; Estados Unidos
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Materia
Progesterone
Progesterone Receptors
Neuroprotection
Hormone Replacement Therapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25465
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Progesterone and progestins: neuroprotection and myelin repairSchumacher, MichaelSitruk Ware, Reginede Nicola, Alejandro FedericoProgesteroneProgesterone ReceptorsNeuroprotectionHormone Replacement Therapyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. This concept has recently been translated into clinical practice, though there is need for more experimental studies and investigations on the mechanisms of the actions of progesterone. However, it is important to be aware that most of the experimental research concerns the effects of physiological progesterone. Although progesterone represents an interesting therapeutic option, the recognition of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (HRTs).Fil: Schumacher, Michael. Inserm; FranciaFil: Sitruk Ware, Regine. The Rockefeller University; Estados UnidosFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaElsevier2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25465Schumacher, Michael; Sitruk Ware, Regine; de Nicola, Alejandro Federico; Progesterone and progestins: neuroprotection and myelin repair; Elsevier; Current Opinion In Pharmacology; 8; 6; 12-2008; 740-7461471-48921471-4973CONICET DigitalCONICETengErratum in Curr Opin Pharmacol. 2009 Apr;9(2):227info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1471489208001586info:eu-repo/semantics/altIdentifier/doi/10.1016/j.coph.2008.10.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:21Zoai:ri.conicet.gov.ar:11336/25465instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:21.515CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone and progestins: neuroprotection and myelin repair
title Progesterone and progestins: neuroprotection and myelin repair
spellingShingle Progesterone and progestins: neuroprotection and myelin repair
Schumacher, Michael
Progesterone
Progesterone Receptors
Neuroprotection
Hormone Replacement Therapy
title_short Progesterone and progestins: neuroprotection and myelin repair
title_full Progesterone and progestins: neuroprotection and myelin repair
title_fullStr Progesterone and progestins: neuroprotection and myelin repair
title_full_unstemmed Progesterone and progestins: neuroprotection and myelin repair
title_sort Progesterone and progestins: neuroprotection and myelin repair
dc.creator.none.fl_str_mv Schumacher, Michael
Sitruk Ware, Regine
de Nicola, Alejandro Federico
author Schumacher, Michael
author_facet Schumacher, Michael
Sitruk Ware, Regine
de Nicola, Alejandro Federico
author_role author
author2 Sitruk Ware, Regine
de Nicola, Alejandro Federico
author2_role author
author
dc.subject.none.fl_str_mv Progesterone
Progesterone Receptors
Neuroprotection
Hormone Replacement Therapy
topic Progesterone
Progesterone Receptors
Neuroprotection
Hormone Replacement Therapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. This concept has recently been translated into clinical practice, though there is need for more experimental studies and investigations on the mechanisms of the actions of progesterone. However, it is important to be aware that most of the experimental research concerns the effects of physiological progesterone. Although progesterone represents an interesting therapeutic option, the recognition of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (HRTs).
Fil: Schumacher, Michael. Inserm; Francia
Fil: Sitruk Ware, Regine. The Rockefeller University; Estados Unidos
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
description Progesterone, known for its role in pregnancy, also exerts marked effects on the nervous system. Its neuroprotective and promyelinating actions, now well documented by experimental studies, make it a particularly promising therapeutic agent for neuroinjury and neurodegenerative diseases. This concept has recently been translated into clinical practice, though there is need for more experimental studies and investigations on the mechanisms of the actions of progesterone. However, it is important to be aware that most of the experimental research concerns the effects of physiological progesterone. Although progesterone represents an interesting therapeutic option, the recognition of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (HRTs).
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25465
Schumacher, Michael; Sitruk Ware, Regine; de Nicola, Alejandro Federico; Progesterone and progestins: neuroprotection and myelin repair; Elsevier; Current Opinion In Pharmacology; 8; 6; 12-2008; 740-746
1471-4892
1471-4973
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25465
identifier_str_mv Schumacher, Michael; Sitruk Ware, Regine; de Nicola, Alejandro Federico; Progesterone and progestins: neuroprotection and myelin repair; Elsevier; Current Opinion In Pharmacology; 8; 6; 12-2008; 740-746
1471-4892
1471-4973
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Erratum in Curr Opin Pharmacol. 2009 Apr;9(2):227
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1471489208001586
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.coph.2008.10.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269633730576384
score 13.13397

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