Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria

Autores
Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; Narum, David; Nielsen, Morten A.; Oleinikov, Andrew V.; Resende, Mafalda; Salanti, Ali; Saveria, Tracy; Williamson, Kathryn; Dicko, Alassane; Scherf, Artur; Smith, Joseph D.; Theander, Thor G.; Duffy, Patrick E.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.
Fil: Fried, Michal. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Avril, Marion. Seattle Biomedical Research Institute; Estados Unidos
Fil: Chaturvedi, Richa. Seattle Biomedical Research Institute; Estados Unidos
Fil: Fernandez, Pablo Mariano. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Lograsso, Joseph. Seattle Biomedical Research Institute; Estados Unidos
Fil: Narum, David. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Nielsen, Morten A.. Universidad de Copenhagen; Dinamarca
Fil: Oleinikov, Andrew V.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Resende, Mafalda. Universidad de Copenhagen; Dinamarca
Fil: Salanti, Ali. Universidad de Copenhagen; Dinamarca
Fil: Saveria, Tracy. Seattle Biomedical Research Institute; Estados Unidos
Fil: Williamson, Kathryn. Seattle Biomedical Research Institute; Estados Unidos
Fil: Dicko, Alassane. University of Bamako; Malí
Fil: Scherf, Artur. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Smith, Joseph D.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Theander, Thor G.. Universidad de Copenhagen; Dinamarca
Fil: Duffy, Patrick E.. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos
Materia
Multilaboratory Approach
Pregnancy Malaria
Antiadhesion Antibodies
Vaccine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12440

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oai_identifier_str oai:ri.conicet.gov.ar:11336/12440
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malariaFried, MichalAvril, MarionChaturvedi, RichaFernandez, Pablo MarianoLograsso, JosephNarum, DavidNielsen, Morten A.Oleinikov, Andrew V.Resende, MafaldaSalanti, AliSaveria, TracyWilliamson, KathrynDicko, AlassaneScherf, ArturSmith, Joseph D.Theander, Thor G.Duffy, Patrick E.Multilaboratory ApproachPregnancy MalariaAntiadhesion AntibodiesVaccinehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.Fil: Fried, Michal. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados UnidosFil: Avril, Marion. Seattle Biomedical Research Institute; Estados UnidosFil: Chaturvedi, Richa. Seattle Biomedical Research Institute; Estados UnidosFil: Fernandez, Pablo Mariano. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Lograsso, Joseph. Seattle Biomedical Research Institute; Estados UnidosFil: Narum, David. Public Health Service. National Institute Of Health; Estados UnidosFil: Nielsen, Morten A.. Universidad de Copenhagen; DinamarcaFil: Oleinikov, Andrew V.. Seattle Biomedical Research Institute; Estados UnidosFil: Resende, Mafalda. Universidad de Copenhagen; DinamarcaFil: Salanti, Ali. Universidad de Copenhagen; DinamarcaFil: Saveria, Tracy. Seattle Biomedical Research Institute; Estados UnidosFil: Williamson, Kathryn. Seattle Biomedical Research Institute; Estados UnidosFil: Dicko, Alassane. University of Bamako; MalíFil: Scherf, Artur. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; FranciaFil: Smith, Joseph D.. Seattle Biomedical Research Institute; Estados UnidosFil: Theander, Thor G.. Universidad de Copenhagen; DinamarcaFil: Duffy, Patrick E.. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados UnidosAmerican Society For Microbiology2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12440Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; et al.; Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria; American Society For Microbiology; Infection And Immunity; 81; 2; 2-2013; 487-4960019-9567enginfo:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/2/487.longinfo:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.01106-12info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:17Zoai:ri.conicet.gov.ar:11336/12440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:18.04CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
title Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
spellingShingle Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
Fried, Michal
Multilaboratory Approach
Pregnancy Malaria
Antiadhesion Antibodies
Vaccine
title_short Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
title_full Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
title_fullStr Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
title_full_unstemmed Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
title_sort Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
dc.creator.none.fl_str_mv Fried, Michal
Avril, Marion
Chaturvedi, Richa
Fernandez, Pablo Mariano
Lograsso, Joseph
Narum, David
Nielsen, Morten A.
Oleinikov, Andrew V.
Resende, Mafalda
Salanti, Ali
Saveria, Tracy
Williamson, Kathryn
Dicko, Alassane
Scherf, Artur
Smith, Joseph D.
Theander, Thor G.
Duffy, Patrick E.
author Fried, Michal
author_facet Fried, Michal
Avril, Marion
Chaturvedi, Richa
Fernandez, Pablo Mariano
Lograsso, Joseph
Narum, David
Nielsen, Morten A.
Oleinikov, Andrew V.
Resende, Mafalda
Salanti, Ali
Saveria, Tracy
Williamson, Kathryn
Dicko, Alassane
Scherf, Artur
Smith, Joseph D.
Theander, Thor G.
Duffy, Patrick E.
author_role author
author2 Avril, Marion
Chaturvedi, Richa
Fernandez, Pablo Mariano
Lograsso, Joseph
Narum, David
Nielsen, Morten A.
Oleinikov, Andrew V.
Resende, Mafalda
Salanti, Ali
Saveria, Tracy
Williamson, Kathryn
Dicko, Alassane
Scherf, Artur
Smith, Joseph D.
Theander, Thor G.
Duffy, Patrick E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Multilaboratory Approach
Pregnancy Malaria
Antiadhesion Antibodies
Vaccine
topic Multilaboratory Approach
Pregnancy Malaria
Antiadhesion Antibodies
Vaccine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.
Fil: Fried, Michal. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Avril, Marion. Seattle Biomedical Research Institute; Estados Unidos
Fil: Chaturvedi, Richa. Seattle Biomedical Research Institute; Estados Unidos
Fil: Fernandez, Pablo Mariano. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Lograsso, Joseph. Seattle Biomedical Research Institute; Estados Unidos
Fil: Narum, David. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Nielsen, Morten A.. Universidad de Copenhagen; Dinamarca
Fil: Oleinikov, Andrew V.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Resende, Mafalda. Universidad de Copenhagen; Dinamarca
Fil: Salanti, Ali. Universidad de Copenhagen; Dinamarca
Fil: Saveria, Tracy. Seattle Biomedical Research Institute; Estados Unidos
Fil: Williamson, Kathryn. Seattle Biomedical Research Institute; Estados Unidos
Fil: Dicko, Alassane. University of Bamako; Malí
Fil: Scherf, Artur. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Smith, Joseph D.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Theander, Thor G.. Universidad de Copenhagen; Dinamarca
Fil: Duffy, Patrick E.. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos
description Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12440
Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; et al.; Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria; American Society For Microbiology; Infection And Immunity; 81; 2; 2-2013; 487-496
0019-9567
url http://hdl.handle.net/11336/12440
identifier_str_mv Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; et al.; Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria; American Society For Microbiology; Infection And Immunity; 81; 2; 2-2013; 487-496
0019-9567
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/2/487.long
info:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.01106-12
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society For Microbiology
publisher.none.fl_str_mv American Society For Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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