Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
- Autores
- Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; Narum, David; Nielsen, Morten A.; Oleinikov, Andrew V.; Resende, Mafalda; Salanti, Ali; Saveria, Tracy; Williamson, Kathryn; Dicko, Alassane; Scherf, Artur; Smith, Joseph D.; Theander, Thor G.; Duffy, Patrick E.
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.
Fil: Fried, Michal. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Avril, Marion. Seattle Biomedical Research Institute; Estados Unidos
Fil: Chaturvedi, Richa. Seattle Biomedical Research Institute; Estados Unidos
Fil: Fernandez, Pablo Mariano. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Lograsso, Joseph. Seattle Biomedical Research Institute; Estados Unidos
Fil: Narum, David. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Nielsen, Morten A.. Universidad de Copenhagen; Dinamarca
Fil: Oleinikov, Andrew V.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Resende, Mafalda. Universidad de Copenhagen; Dinamarca
Fil: Salanti, Ali. Universidad de Copenhagen; Dinamarca
Fil: Saveria, Tracy. Seattle Biomedical Research Institute; Estados Unidos
Fil: Williamson, Kathryn. Seattle Biomedical Research Institute; Estados Unidos
Fil: Dicko, Alassane. University of Bamako; Malí
Fil: Scherf, Artur. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Smith, Joseph D.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Theander, Thor G.. Universidad de Copenhagen; Dinamarca
Fil: Duffy, Patrick E.. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos - Materia
-
Multilaboratory Approach
Pregnancy Malaria
Antiadhesion Antibodies
Vaccine - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/12440
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Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malariaFried, MichalAvril, MarionChaturvedi, RichaFernandez, Pablo MarianoLograsso, JosephNarum, DavidNielsen, Morten A.Oleinikov, Andrew V.Resende, MafaldaSalanti, AliSaveria, TracyWilliamson, KathrynDicko, AlassaneScherf, ArturSmith, Joseph D.Theander, Thor G.Duffy, Patrick E.Multilaboratory ApproachPregnancy MalariaAntiadhesion AntibodiesVaccinehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.Fil: Fried, Michal. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados UnidosFil: Avril, Marion. Seattle Biomedical Research Institute; Estados UnidosFil: Chaturvedi, Richa. Seattle Biomedical Research Institute; Estados UnidosFil: Fernandez, Pablo Mariano. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Lograsso, Joseph. Seattle Biomedical Research Institute; Estados UnidosFil: Narum, David. Public Health Service. National Institute Of Health; Estados UnidosFil: Nielsen, Morten A.. Universidad de Copenhagen; DinamarcaFil: Oleinikov, Andrew V.. Seattle Biomedical Research Institute; Estados UnidosFil: Resende, Mafalda. Universidad de Copenhagen; DinamarcaFil: Salanti, Ali. Universidad de Copenhagen; DinamarcaFil: Saveria, Tracy. Seattle Biomedical Research Institute; Estados UnidosFil: Williamson, Kathryn. Seattle Biomedical Research Institute; Estados UnidosFil: Dicko, Alassane. University of Bamako; MalíFil: Scherf, Artur. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; FranciaFil: Smith, Joseph D.. Seattle Biomedical Research Institute; Estados UnidosFil: Theander, Thor G.. Universidad de Copenhagen; DinamarcaFil: Duffy, Patrick E.. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados UnidosAmerican Society For Microbiology2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12440Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; et al.; Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria; American Society For Microbiology; Infection And Immunity; 81; 2; 2-2013; 487-4960019-9567enginfo:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/2/487.longinfo:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.01106-12info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:17Zoai:ri.conicet.gov.ar:11336/12440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:18.04CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
title |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
spellingShingle |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria Fried, Michal Multilaboratory Approach Pregnancy Malaria Antiadhesion Antibodies Vaccine |
title_short |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
title_full |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
title_fullStr |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
title_full_unstemmed |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
title_sort |
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria |
dc.creator.none.fl_str_mv |
Fried, Michal Avril, Marion Chaturvedi, Richa Fernandez, Pablo Mariano Lograsso, Joseph Narum, David Nielsen, Morten A. Oleinikov, Andrew V. Resende, Mafalda Salanti, Ali Saveria, Tracy Williamson, Kathryn Dicko, Alassane Scherf, Artur Smith, Joseph D. Theander, Thor G. Duffy, Patrick E. |
author |
Fried, Michal |
author_facet |
Fried, Michal Avril, Marion Chaturvedi, Richa Fernandez, Pablo Mariano Lograsso, Joseph Narum, David Nielsen, Morten A. Oleinikov, Andrew V. Resende, Mafalda Salanti, Ali Saveria, Tracy Williamson, Kathryn Dicko, Alassane Scherf, Artur Smith, Joseph D. Theander, Thor G. Duffy, Patrick E. |
author_role |
author |
author2 |
Avril, Marion Chaturvedi, Richa Fernandez, Pablo Mariano Lograsso, Joseph Narum, David Nielsen, Morten A. Oleinikov, Andrew V. Resende, Mafalda Salanti, Ali Saveria, Tracy Williamson, Kathryn Dicko, Alassane Scherf, Artur Smith, Joseph D. Theander, Thor G. Duffy, Patrick E. |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Multilaboratory Approach Pregnancy Malaria Antiadhesion Antibodies Vaccine |
topic |
Multilaboratory Approach Pregnancy Malaria Antiadhesion Antibodies Vaccine |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens. Fil: Fried, Michal. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos Fil: Avril, Marion. Seattle Biomedical Research Institute; Estados Unidos Fil: Chaturvedi, Richa. Seattle Biomedical Research Institute; Estados Unidos Fil: Fernandez, Pablo Mariano. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina Fil: Lograsso, Joseph. Seattle Biomedical Research Institute; Estados Unidos Fil: Narum, David. Public Health Service. National Institute Of Health; Estados Unidos Fil: Nielsen, Morten A.. Universidad de Copenhagen; Dinamarca Fil: Oleinikov, Andrew V.. Seattle Biomedical Research Institute; Estados Unidos Fil: Resende, Mafalda. Universidad de Copenhagen; Dinamarca Fil: Salanti, Ali. Universidad de Copenhagen; Dinamarca Fil: Saveria, Tracy. Seattle Biomedical Research Institute; Estados Unidos Fil: Williamson, Kathryn. Seattle Biomedical Research Institute; Estados Unidos Fil: Dicko, Alassane. University of Bamako; Malí Fil: Scherf, Artur. Instituto Pasteur; Francia. Centre National de la Recherche Scientifique; Francia Fil: Smith, Joseph D.. Seattle Biomedical Research Institute; Estados Unidos Fil: Theander, Thor G.. Universidad de Copenhagen; Dinamarca Fil: Duffy, Patrick E.. Seattle Biomedical Research Institute; Estados Unidos. Public Health Service. National Institute Of Health; Estados Unidos |
description |
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/12440 Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; et al.; Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria; American Society For Microbiology; Infection And Immunity; 81; 2; 2-2013; 487-496 0019-9567 |
url |
http://hdl.handle.net/11336/12440 |
identifier_str_mv |
Fried, Michal; Avril, Marion; Chaturvedi, Richa; Fernandez, Pablo Mariano; Lograsso, Joseph; et al.; Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria; American Society For Microbiology; Infection And Immunity; 81; 2; 2-2013; 487-496 0019-9567 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/2/487.long info:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.01106-12 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society For Microbiology |
publisher.none.fl_str_mv |
American Society For Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269573626200064 |
score |
13.13397 |