Endogenous galectin-3 controls experimental malaria in a species-specific manner

Autores
Toscano, Marta Alicia; Tongren, J. E.; De Souza, J. B.; Liu, F. T.; Riley, E. M.; Rabinovich, Gabriel Adrián
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host–pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3−/− mice was consistent with higher titres of anti-P. yoelii MSP119 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host–pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Tongren, J. E.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: De Souza, J. B.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Liu, F. T.. University of California at Davis; Estados Unidos
Fil: Riley, E. M.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
Parasites
Malaria
Galectin-3
Immunoglobulins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22207
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22207
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endogenous galectin-3 controls experimental malaria in a species-specific mannerToscano, Marta AliciaTongren, J. E.De Souza, J. B.Liu, F. T.Riley, E. M.Rabinovich, Gabriel AdriánParasitesMalariaGalectin-3Immunoglobulinshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host–pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3−/− mice was consistent with higher titres of anti-P. yoelii MSP119 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host–pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Tongren, J. E.. London School of Hygiene and Tropical Medicine; Reino UnidoFil: De Souza, J. B.. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Liu, F. T.. University of California at Davis; Estados UnidosFil: Riley, E. M.. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaWiley2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22207Toscano, Marta Alicia; Tongren, J. E.; De Souza, J. B.; Liu, F. T.; Riley, E. M.; et al.; Endogenous galectin-3 controls experimental malaria in a species-specific manner; Wiley; Parasite Immunology; 34; 7; 6-2012; 383-3870141-98381365-3024CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-3024.2012.01366.xinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01366.x/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:05Zoai:ri.conicet.gov.ar:11336/22207instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:05.599CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endogenous galectin-3 controls experimental malaria in a species-specific manner
title Endogenous galectin-3 controls experimental malaria in a species-specific manner
spellingShingle Endogenous galectin-3 controls experimental malaria in a species-specific manner
Toscano, Marta Alicia
Parasites
Malaria
Galectin-3
Immunoglobulins
title_short Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_full Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_fullStr Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_full_unstemmed Endogenous galectin-3 controls experimental malaria in a species-specific manner
title_sort Endogenous galectin-3 controls experimental malaria in a species-specific manner
dc.creator.none.fl_str_mv Toscano, Marta Alicia
Tongren, J. E.
De Souza, J. B.
Liu, F. T.
Riley, E. M.
Rabinovich, Gabriel Adrián
author Toscano, Marta Alicia
author_facet Toscano, Marta Alicia
Tongren, J. E.
De Souza, J. B.
Liu, F. T.
Riley, E. M.
Rabinovich, Gabriel Adrián
author_role author
author2 Tongren, J. E.
De Souza, J. B.
Liu, F. T.
Riley, E. M.
Rabinovich, Gabriel Adrián
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Parasites
Malaria
Galectin-3
Immunoglobulins
topic Parasites
Malaria
Galectin-3
Immunoglobulins
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host–pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3−/− mice was consistent with higher titres of anti-P. yoelii MSP119 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host–pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Tongren, J. E.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: De Souza, J. B.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Liu, F. T.. University of California at Davis; Estados Unidos
Fil: Riley, E. M.. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host–pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3−/− mice was consistent with higher titres of anti-P. yoelii MSP119 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host–pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22207
Toscano, Marta Alicia; Tongren, J. E.; De Souza, J. B.; Liu, F. T.; Riley, E. M.; et al.; Endogenous galectin-3 controls experimental malaria in a species-specific manner; Wiley; Parasite Immunology; 34; 7; 6-2012; 383-387
0141-9838
1365-3024
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22207
identifier_str_mv Toscano, Marta Alicia; Tongren, J. E.; De Souza, J. B.; Liu, F. T.; Riley, E. M.; et al.; Endogenous galectin-3 controls experimental malaria in a species-specific manner; Wiley; Parasite Immunology; 34; 7; 6-2012; 383-387
0141-9838
1365-3024
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-3024.2012.01366.x
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01366.x/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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