The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of mal...

Autores
Pampillo, Macarena; Scimonelli, Teresa Nieves; Duvilanski, Beatriz Haydee; Celis, María Ester; Seilicovich, Adriana; Lasaga, Mercedes Isabel
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to investigate the effect of metabotropic glutamate receptor (mGluR) activation on gamma-aminobutyric acid (GABA) and α-melanocyte stimulating hormone (α-MSH) release from hypothalamic fragments and posterior pituitaries. The actions of a number of subtype-selective mGluR agonists were monitored. A group I mGluR agonist, (S)-3-hydroxyphenylglycine (3-HPG; 0.5 mM), decreased K+-induced hypothalamic GABA release. (RS)-1-Aminoindan-1,5-dicarboxylic acid (AIDA), a specific group I mGluR antagonist (0.2 mM), blocked the effect of 3-HPG. (2S, 1′S, 2′S)-2-(Carboxycyclopropyl) glycine (L-CCG-I) and L-serine-O-phosphate (L-SOP; 0.01-1 mM), agonists of group II and III mGluRs, respectively, did not modify hypothalamic evoked GABA release. Group I mGluR activation decreased, whereas group III increased and group II induced no changes in GABA release from the posterior pituitary. 3-HPG (1 mM) and L-CCG-I (0.1 mM) decreased, whereas L-SOP (0.01-0.1 mM) did not change α-MSH release from hypothalamic fragments. No agonists of the three mGluR groups modified α-MSH release from the posterior pituitary. These results indicate that activation of mGluRs differentially affects GABA and α-MSH release from the hypothalamus and the posterior pituitary.
Fil: Pampillo, Macarena. Centro de Investigaciones En Reproducción; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Duvilanski, Beatriz Haydee. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
Fil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
Α-MELANOCYTE STIMULATING HORMONE
GAMMA-AMINOBUTYRIC ACID
HYPOTHALAMUS
METABOTROPIC GLUTAMATE RECEPTORS
POSTERIOR PITUITARY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115767
Acceder
id CONICETDig_dc4a5e9f366fdfea7a9c4d41c4f983dc
oai_identifier_str oai:ri.conicet.gov.ar:11336/115767
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male ratsPampillo, MacarenaScimonelli, Teresa NievesDuvilanski, Beatriz HaydeeCelis, María EsterSeilicovich, AdrianaLasaga, Mercedes IsabelΑ-MELANOCYTE STIMULATING HORMONEGAMMA-AMINOBUTYRIC ACIDHYPOTHALAMUSMETABOTROPIC GLUTAMATE RECEPTORSPOSTERIOR PITUITARYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of the present study was to investigate the effect of metabotropic glutamate receptor (mGluR) activation on gamma-aminobutyric acid (GABA) and α-melanocyte stimulating hormone (α-MSH) release from hypothalamic fragments and posterior pituitaries. The actions of a number of subtype-selective mGluR agonists were monitored. A group I mGluR agonist, (S)-3-hydroxyphenylglycine (3-HPG; 0.5 mM), decreased K+-induced hypothalamic GABA release. (RS)-1-Aminoindan-1,5-dicarboxylic acid (AIDA), a specific group I mGluR antagonist (0.2 mM), blocked the effect of 3-HPG. (2S, 1′S, 2′S)-2-(Carboxycyclopropyl) glycine (L-CCG-I) and L-serine-O-phosphate (L-SOP; 0.01-1 mM), agonists of group II and III mGluRs, respectively, did not modify hypothalamic evoked GABA release. Group I mGluR activation decreased, whereas group III increased and group II induced no changes in GABA release from the posterior pituitary. 3-HPG (1 mM) and L-CCG-I (0.1 mM) decreased, whereas L-SOP (0.01-0.1 mM) did not change α-MSH release from hypothalamic fragments. No agonists of the three mGluR groups modified α-MSH release from the posterior pituitary. These results indicate that activation of mGluRs differentially affects GABA and α-MSH release from the hypothalamus and the posterior pituitary.Fil: Pampillo, Macarena. Centro de Investigaciones En Reproducción; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Duvilanski, Beatriz Haydee. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaFil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaFil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaElsevier Ireland2002-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115767Pampillo, Macarena; Scimonelli, Teresa Nieves; Duvilanski, Beatriz Haydee; Celis, María Ester; Seilicovich, Adriana; et al.; The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats; Elsevier Ireland; Neuroscience Letters; 327; 2; 7-2002; 95-980304-3940CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0304-3940(02)00386-5info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0304394002003865info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:56Zoai:ri.conicet.gov.ar:11336/115767instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:57.124CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
title The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
spellingShingle The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
Pampillo, Macarena
Α-MELANOCYTE STIMULATING HORMONE
GAMMA-AMINOBUTYRIC ACID
HYPOTHALAMUS
METABOTROPIC GLUTAMATE RECEPTORS
POSTERIOR PITUITARY
title_short The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
title_full The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
title_fullStr The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
title_full_unstemmed The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
title_sort The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats
dc.creator.none.fl_str_mv Pampillo, Macarena
Scimonelli, Teresa Nieves
Duvilanski, Beatriz Haydee
Celis, María Ester
Seilicovich, Adriana
Lasaga, Mercedes Isabel
author Pampillo, Macarena
author_facet Pampillo, Macarena
Scimonelli, Teresa Nieves
Duvilanski, Beatriz Haydee
Celis, María Ester
Seilicovich, Adriana
Lasaga, Mercedes Isabel
author_role author
author2 Scimonelli, Teresa Nieves
Duvilanski, Beatriz Haydee
Celis, María Ester
Seilicovich, Adriana
Lasaga, Mercedes Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Α-MELANOCYTE STIMULATING HORMONE
GAMMA-AMINOBUTYRIC ACID
HYPOTHALAMUS
METABOTROPIC GLUTAMATE RECEPTORS
POSTERIOR PITUITARY
topic Α-MELANOCYTE STIMULATING HORMONE
GAMMA-AMINOBUTYRIC ACID
HYPOTHALAMUS
METABOTROPIC GLUTAMATE RECEPTORS
POSTERIOR PITUITARY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present study was to investigate the effect of metabotropic glutamate receptor (mGluR) activation on gamma-aminobutyric acid (GABA) and α-melanocyte stimulating hormone (α-MSH) release from hypothalamic fragments and posterior pituitaries. The actions of a number of subtype-selective mGluR agonists were monitored. A group I mGluR agonist, (S)-3-hydroxyphenylglycine (3-HPG; 0.5 mM), decreased K+-induced hypothalamic GABA release. (RS)-1-Aminoindan-1,5-dicarboxylic acid (AIDA), a specific group I mGluR antagonist (0.2 mM), blocked the effect of 3-HPG. (2S, 1′S, 2′S)-2-(Carboxycyclopropyl) glycine (L-CCG-I) and L-serine-O-phosphate (L-SOP; 0.01-1 mM), agonists of group II and III mGluRs, respectively, did not modify hypothalamic evoked GABA release. Group I mGluR activation decreased, whereas group III increased and group II induced no changes in GABA release from the posterior pituitary. 3-HPG (1 mM) and L-CCG-I (0.1 mM) decreased, whereas L-SOP (0.01-0.1 mM) did not change α-MSH release from hypothalamic fragments. No agonists of the three mGluR groups modified α-MSH release from the posterior pituitary. These results indicate that activation of mGluRs differentially affects GABA and α-MSH release from the hypothalamus and the posterior pituitary.
Fil: Pampillo, Macarena. Centro de Investigaciones En Reproducción; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Duvilanski, Beatriz Haydee. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
Fil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description The aim of the present study was to investigate the effect of metabotropic glutamate receptor (mGluR) activation on gamma-aminobutyric acid (GABA) and α-melanocyte stimulating hormone (α-MSH) release from hypothalamic fragments and posterior pituitaries. The actions of a number of subtype-selective mGluR agonists were monitored. A group I mGluR agonist, (S)-3-hydroxyphenylglycine (3-HPG; 0.5 mM), decreased K+-induced hypothalamic GABA release. (RS)-1-Aminoindan-1,5-dicarboxylic acid (AIDA), a specific group I mGluR antagonist (0.2 mM), blocked the effect of 3-HPG. (2S, 1′S, 2′S)-2-(Carboxycyclopropyl) glycine (L-CCG-I) and L-serine-O-phosphate (L-SOP; 0.01-1 mM), agonists of group II and III mGluRs, respectively, did not modify hypothalamic evoked GABA release. Group I mGluR activation decreased, whereas group III increased and group II induced no changes in GABA release from the posterior pituitary. 3-HPG (1 mM) and L-CCG-I (0.1 mM) decreased, whereas L-SOP (0.01-0.1 mM) did not change α-MSH release from hypothalamic fragments. No agonists of the three mGluR groups modified α-MSH release from the posterior pituitary. These results indicate that activation of mGluRs differentially affects GABA and α-MSH release from the hypothalamus and the posterior pituitary.
publishDate 2002
dc.date.none.fl_str_mv 2002-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115767
Pampillo, Macarena; Scimonelli, Teresa Nieves; Duvilanski, Beatriz Haydee; Celis, María Ester; Seilicovich, Adriana; et al.; The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats; Elsevier Ireland; Neuroscience Letters; 327; 2; 7-2002; 95-98
0304-3940
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115767
identifier_str_mv Pampillo, Macarena; Scimonelli, Teresa Nieves; Duvilanski, Beatriz Haydee; Celis, María Ester; Seilicovich, Adriana; et al.; The activation of metabotropic glutamate receptors differentially affects GABA and α-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats; Elsevier Ireland; Neuroscience Letters; 327; 2; 7-2002; 95-98
0304-3940
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/S0304-3940(02)00386-5
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0304394002003865
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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