Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
- Autores
- Rossatto Temp, Fernanda; Santos, Aline Carré; Marafiga, Joseane Righes; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; Oliveira, Sara Marquesan; Guerra, Gustavo Petri; Scimonelli, Teresa Nieves; Mello, Carlos Fernando
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure control
Fil: Rossatto Temp, Fernanda. Universidade Federal de Santa Maria; Brasil
Fil: Santos, Aline Carré. Universidade Federal de Santa Maria; Brasil
Fil: Marafiga, Joseane Righes. Universidade Federal de Santa Maria; Brasil
Fil: Jesse, Ana Cláudia. Universidade Federal de Santa Maria; Brasil
Fil: Lenz, Quéli Fernandes. Universidade Federal de Santa Maria; Brasil
Fil: Oliveira, Sara Marquesan. Universidade Federal de Santa Maria; Brasil
Fil: Guerra, Gustavo Petri. Universidade Tecnológica Federal do Paraná; Brasil
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Mello, Carlos Fernando. Universidade Federal de Santa Maria; Brasil - Materia
-
Melanocyte-Stimulating-Hormone
Central Inflammation
Epilepsy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/26370
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Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizuresRossatto Temp, FernandaSantos, Aline CarréMarafiga, Joseane RighesJesse, Ana CláudiaLenz, Quéli FernandesOliveira, Sara MarquesanGuerra, Gustavo PetriScimonelli, Teresa NievesMello, Carlos FernandoMelanocyte-Stimulating-HormoneCentral InflammationEpilepsyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure controlFil: Rossatto Temp, Fernanda. Universidade Federal de Santa Maria; BrasilFil: Santos, Aline Carré. Universidade Federal de Santa Maria; BrasilFil: Marafiga, Joseane Righes. Universidade Federal de Santa Maria; BrasilFil: Jesse, Ana Cláudia. Universidade Federal de Santa Maria; BrasilFil: Lenz, Quéli Fernandes. Universidade Federal de Santa Maria; BrasilFil: Oliveira, Sara Marquesan. Universidade Federal de Santa Maria; BrasilFil: Guerra, Gustavo Petri. Universidade Tecnológica Federal do Paraná; BrasilFil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Mello, Carlos Fernando. Universidade Federal de Santa Maria; BrasilElsevier Inc2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26370Rossatto Temp, Fernanda; Santos, Aline Carré ; Marafiga, Joseane Righes ; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; et al.; Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures; Elsevier Inc; Life Sciences; 93; 20; 9-2013; 723-7310024-3205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2013.09.006info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0024320513005183info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:42Zoai:ri.conicet.gov.ar:11336/26370instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:42.556CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
title |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
spellingShingle |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures Rossatto Temp, Fernanda Melanocyte-Stimulating-Hormone Central Inflammation Epilepsy |
title_short |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
title_full |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
title_fullStr |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
title_full_unstemmed |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
title_sort |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures |
dc.creator.none.fl_str_mv |
Rossatto Temp, Fernanda Santos, Aline Carré Marafiga, Joseane Righes Jesse, Ana Cláudia Lenz, Quéli Fernandes Oliveira, Sara Marquesan Guerra, Gustavo Petri Scimonelli, Teresa Nieves Mello, Carlos Fernando |
author |
Rossatto Temp, Fernanda |
author_facet |
Rossatto Temp, Fernanda Santos, Aline Carré Marafiga, Joseane Righes Jesse, Ana Cláudia Lenz, Quéli Fernandes Oliveira, Sara Marquesan Guerra, Gustavo Petri Scimonelli, Teresa Nieves Mello, Carlos Fernando |
author_role |
author |
author2 |
Santos, Aline Carré Marafiga, Joseane Righes Jesse, Ana Cláudia Lenz, Quéli Fernandes Oliveira, Sara Marquesan Guerra, Gustavo Petri Scimonelli, Teresa Nieves Mello, Carlos Fernando |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Melanocyte-Stimulating-Hormone Central Inflammation Epilepsy |
topic |
Melanocyte-Stimulating-Hormone Central Inflammation Epilepsy |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure control Fil: Rossatto Temp, Fernanda. Universidade Federal de Santa Maria; Brasil Fil: Santos, Aline Carré. Universidade Federal de Santa Maria; Brasil Fil: Marafiga, Joseane Righes. Universidade Federal de Santa Maria; Brasil Fil: Jesse, Ana Cláudia. Universidade Federal de Santa Maria; Brasil Fil: Lenz, Quéli Fernandes. Universidade Federal de Santa Maria; Brasil Fil: Oliveira, Sara Marquesan. Universidade Federal de Santa Maria; Brasil Fil: Guerra, Gustavo Petri. Universidade Tecnológica Federal do Paraná; Brasil Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Mello, Carlos Fernando. Universidade Federal de Santa Maria; Brasil |
description |
Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure control |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/26370 Rossatto Temp, Fernanda; Santos, Aline Carré ; Marafiga, Joseane Righes ; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; et al.; Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures; Elsevier Inc; Life Sciences; 93; 20; 9-2013; 723-731 0024-3205 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/26370 |
identifier_str_mv |
Rossatto Temp, Fernanda; Santos, Aline Carré ; Marafiga, Joseane Righes ; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; et al.; Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures; Elsevier Inc; Life Sciences; 93; 20; 9-2013; 723-731 0024-3205 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2013.09.006 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0024320513005183 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Inc |
publisher.none.fl_str_mv |
Elsevier Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269301582594048 |
score |
13.13397 |