Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures

Autores
Rossatto Temp, Fernanda; Santos, Aline Carré; Marafiga, Joseane Righes; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; Oliveira, Sara Marquesan; Guerra, Gustavo Petri; Scimonelli, Teresa Nieves; Mello, Carlos Fernando
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure control
Fil: Rossatto Temp, Fernanda. Universidade Federal de Santa Maria; Brasil
Fil: Santos, Aline Carré. Universidade Federal de Santa Maria; Brasil
Fil: Marafiga, Joseane Righes. Universidade Federal de Santa Maria; Brasil
Fil: Jesse, Ana Cláudia. Universidade Federal de Santa Maria; Brasil
Fil: Lenz, Quéli Fernandes. Universidade Federal de Santa Maria; Brasil
Fil: Oliveira, Sara Marquesan. Universidade Federal de Santa Maria; Brasil
Fil: Guerra, Gustavo Petri. Universidade Tecnológica Federal do Paraná; Brasil
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Mello, Carlos Fernando. Universidade Federal de Santa Maria; Brasil
Materia
Melanocyte-Stimulating-Hormone
Central Inflammation
Epilepsy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26370

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizuresRossatto Temp, FernandaSantos, Aline CarréMarafiga, Joseane RighesJesse, Ana CláudiaLenz, Quéli FernandesOliveira, Sara MarquesanGuerra, Gustavo PetriScimonelli, Teresa NievesMello, Carlos FernandoMelanocyte-Stimulating-HormoneCentral InflammationEpilepsyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure controlFil: Rossatto Temp, Fernanda. Universidade Federal de Santa Maria; BrasilFil: Santos, Aline Carré. Universidade Federal de Santa Maria; BrasilFil: Marafiga, Joseane Righes. Universidade Federal de Santa Maria; BrasilFil: Jesse, Ana Cláudia. Universidade Federal de Santa Maria; BrasilFil: Lenz, Quéli Fernandes. Universidade Federal de Santa Maria; BrasilFil: Oliveira, Sara Marquesan. Universidade Federal de Santa Maria; BrasilFil: Guerra, Gustavo Petri. Universidade Tecnológica Federal do Paraná; BrasilFil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Mello, Carlos Fernando. Universidade Federal de Santa Maria; BrasilElsevier Inc2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26370Rossatto Temp, Fernanda; Santos, Aline Carré ; Marafiga, Joseane Righes ; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; et al.; Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures; Elsevier Inc; Life Sciences; 93; 20; 9-2013; 723-7310024-3205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2013.09.006info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0024320513005183info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:42Zoai:ri.conicet.gov.ar:11336/26370instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:42.556CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
title Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
spellingShingle Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
Rossatto Temp, Fernanda
Melanocyte-Stimulating-Hormone
Central Inflammation
Epilepsy
title_short Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
title_full Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
title_fullStr Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
title_full_unstemmed Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
title_sort Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures
dc.creator.none.fl_str_mv Rossatto Temp, Fernanda
Santos, Aline Carré
Marafiga, Joseane Righes
Jesse, Ana Cláudia
Lenz, Quéli Fernandes
Oliveira, Sara Marquesan
Guerra, Gustavo Petri
Scimonelli, Teresa Nieves
Mello, Carlos Fernando
author Rossatto Temp, Fernanda
author_facet Rossatto Temp, Fernanda
Santos, Aline Carré
Marafiga, Joseane Righes
Jesse, Ana Cláudia
Lenz, Quéli Fernandes
Oliveira, Sara Marquesan
Guerra, Gustavo Petri
Scimonelli, Teresa Nieves
Mello, Carlos Fernando
author_role author
author2 Santos, Aline Carré
Marafiga, Joseane Righes
Jesse, Ana Cláudia
Lenz, Quéli Fernandes
Oliveira, Sara Marquesan
Guerra, Gustavo Petri
Scimonelli, Teresa Nieves
Mello, Carlos Fernando
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Melanocyte-Stimulating-Hormone
Central Inflammation
Epilepsy
topic Melanocyte-Stimulating-Hormone
Central Inflammation
Epilepsy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure control
Fil: Rossatto Temp, Fernanda. Universidade Federal de Santa Maria; Brasil
Fil: Santos, Aline Carré. Universidade Federal de Santa Maria; Brasil
Fil: Marafiga, Joseane Righes. Universidade Federal de Santa Maria; Brasil
Fil: Jesse, Ana Cláudia. Universidade Federal de Santa Maria; Brasil
Fil: Lenz, Quéli Fernandes. Universidade Federal de Santa Maria; Brasil
Fil: Oliveira, Sara Marquesan. Universidade Federal de Santa Maria; Brasil
Fil: Guerra, Gustavo Petri. Universidade Tecnológica Federal do Paraná; Brasil
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Mello, Carlos Fernando. Universidade Federal de Santa Maria; Brasil
description Aims: Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether α-MSH modifies seizures. Therefore, in the current study we determined whether α-MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures. Main methods: Adult male Swiss mice were injected with α-MSH (1.66, 5 or 15 μg/3 μL, intracerebroventricular (i.c.v.)) or systemic (0.1, 0.3 or 1 mg/kg, intraperitoneally (i.p.)). Five to sixty minutes after the injection of the peptide, animals were injected with PTZ (60 mg/kg, i.p.) or pilocarpine (370 mg/kg, i.p.). Latency to myoclonic jerks and tonic–clonic seizures, number of seizure episodes, total time spent seizing and seizure intensity, assessed by the Racine and Meurs scales were recorded. Interleukin 1 beta (IL-1β) levels in the hippocampus were measured by a commercial enzyme-linked immunoabsorbent assay (ELISA). Key findings: Neither intracerebroventricular (1.66, 5 or 15 μg/3 μL, i.c.v.) nor systemic (0.1, 0.3 or 1 mg/kg, i.p.) administration of α-MSH altered PTZ- and pilocarpine-induced seizures. IL-1β levels in the hippocampi were not altered by α-MSH, PTZ or pilocarpine. Significance: Although inflammation has been implicated in seizures and epilepsy and α-MSH is a potent antiinflammatory peptide, our results do not support a role for α-MSH in seizure control
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26370
Rossatto Temp, Fernanda; Santos, Aline Carré ; Marafiga, Joseane Righes ; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; et al.; Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures; Elsevier Inc; Life Sciences; 93; 20; 9-2013; 723-731
0024-3205
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26370
identifier_str_mv Rossatto Temp, Fernanda; Santos, Aline Carré ; Marafiga, Joseane Righes ; Jesse, Ana Cláudia; Lenz, Quéli Fernandes; et al.; Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures; Elsevier Inc; Life Sciences; 93; 20; 9-2013; 723-731
0024-3205
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2013.09.006
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0024320513005183
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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