Cell-centred model for the simulation of curved cellular monolayers

Autores
Mosaffa, Payman; Asadipour, Nina; Millán, Raúl Daniel; Rodríguez Ferran, Antonio; Muñoz, Jose J
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper presents a cell-centred model for the simulation of planar and curved multicellular soft tissues. We propose a computational model that includes stress relaxation due to cell reorganisation (intercellular connectivity changes) and cytoskeleton remodelling (intracellular changes). Cells are represented by their cell centres, and their mechanical interaction is modelled through active non-linear elastic laws with a dynamically changing resting length. Special attention is paid to the handling of connectivity changes between cells, and the relaxation that the tissues exhibit under these topological changes. Cell–cell connectivity is computed by resorting to a Delaunay triangulation, which is combined with a mapping technique in order to obtain triangulations on curved manifolds. Our numerical results show that even a linear elastic cell–cell interaction model may induce a global non-linear response due to the reorganisation of the cell connectivity. This plastic-like behaviour is combined with a non-linear rheological law where the resting length depends on the elastic strain, mimicking the global visco-elastic response of tissues. The model is applied to simulate the elongation of planar and curved monolayers.
Fil: Mosaffa, Payman. Universidad Politécnica de Catalunya; España
Fil: Asadipour, Nina. Universidad Politécnica de Catalunya; España
Fil: Millán, Raúl Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Politécnica de Catalunya; España
Fil: Rodríguez Ferran, Antonio. Universidad Politécnica de Catalunya; España
Fil: Muñoz, Jose J. Universidad Politécnica de Catalunya; España
Materia
Biomechanics
Cell-Centred
Delaunay
Morphogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59686
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/59686
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cell-centred model for the simulation of curved cellular monolayersMosaffa, PaymanAsadipour, NinaMillán, Raúl DanielRodríguez Ferran, AntonioMuñoz, Jose JBiomechanicsCell-CentredDelaunayMorphogenesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This paper presents a cell-centred model for the simulation of planar and curved multicellular soft tissues. We propose a computational model that includes stress relaxation due to cell reorganisation (intercellular connectivity changes) and cytoskeleton remodelling (intracellular changes). Cells are represented by their cell centres, and their mechanical interaction is modelled through active non-linear elastic laws with a dynamically changing resting length. Special attention is paid to the handling of connectivity changes between cells, and the relaxation that the tissues exhibit under these topological changes. Cell–cell connectivity is computed by resorting to a Delaunay triangulation, which is combined with a mapping technique in order to obtain triangulations on curved manifolds. Our numerical results show that even a linear elastic cell–cell interaction model may induce a global non-linear response due to the reorganisation of the cell connectivity. This plastic-like behaviour is combined with a non-linear rheological law where the resting length depends on the elastic strain, mimicking the global visco-elastic response of tissues. The model is applied to simulate the elongation of planar and curved monolayers.Fil: Mosaffa, Payman. Universidad Politécnica de Catalunya; EspañaFil: Asadipour, Nina. Universidad Politécnica de Catalunya; EspañaFil: Millán, Raúl Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Politécnica de Catalunya; EspañaFil: Rodríguez Ferran, Antonio. Universidad Politécnica de Catalunya; EspañaFil: Muñoz, Jose J. Universidad Politécnica de Catalunya; EspañaSpringer International Publishing2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59686Mosaffa, Payman; Asadipour, Nina; Millán, Raúl Daniel; Rodríguez Ferran, Antonio; Muñoz, Jose J; Cell-centred model for the simulation of curved cellular monolayers; Springer International Publishing; Computational Particle Mechanics; 2; 4; 12-2015; 359-3702196-43862196-4378CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s40571-015-0043-xinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40571-015-0043-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:28:06Zoai:ri.conicet.gov.ar:11336/59686instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:28:07.235CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cell-centred model for the simulation of curved cellular monolayers
title Cell-centred model for the simulation of curved cellular monolayers
spellingShingle Cell-centred model for the simulation of curved cellular monolayers
Mosaffa, Payman
Biomechanics
Cell-Centred
Delaunay
Morphogenesis
title_short Cell-centred model for the simulation of curved cellular monolayers
title_full Cell-centred model for the simulation of curved cellular monolayers
title_fullStr Cell-centred model for the simulation of curved cellular monolayers
title_full_unstemmed Cell-centred model for the simulation of curved cellular monolayers
title_sort Cell-centred model for the simulation of curved cellular monolayers
dc.creator.none.fl_str_mv Mosaffa, Payman
Asadipour, Nina
Millán, Raúl Daniel
Rodríguez Ferran, Antonio
Muñoz, Jose J
author Mosaffa, Payman
author_facet Mosaffa, Payman
Asadipour, Nina
Millán, Raúl Daniel
Rodríguez Ferran, Antonio
Muñoz, Jose J
author_role author
author2 Asadipour, Nina
Millán, Raúl Daniel
Rodríguez Ferran, Antonio
Muñoz, Jose J
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biomechanics
Cell-Centred
Delaunay
Morphogenesis
topic Biomechanics
Cell-Centred
Delaunay
Morphogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This paper presents a cell-centred model for the simulation of planar and curved multicellular soft tissues. We propose a computational model that includes stress relaxation due to cell reorganisation (intercellular connectivity changes) and cytoskeleton remodelling (intracellular changes). Cells are represented by their cell centres, and their mechanical interaction is modelled through active non-linear elastic laws with a dynamically changing resting length. Special attention is paid to the handling of connectivity changes between cells, and the relaxation that the tissues exhibit under these topological changes. Cell–cell connectivity is computed by resorting to a Delaunay triangulation, which is combined with a mapping technique in order to obtain triangulations on curved manifolds. Our numerical results show that even a linear elastic cell–cell interaction model may induce a global non-linear response due to the reorganisation of the cell connectivity. This plastic-like behaviour is combined with a non-linear rheological law where the resting length depends on the elastic strain, mimicking the global visco-elastic response of tissues. The model is applied to simulate the elongation of planar and curved monolayers.
Fil: Mosaffa, Payman. Universidad Politécnica de Catalunya; España
Fil: Asadipour, Nina. Universidad Politécnica de Catalunya; España
Fil: Millán, Raúl Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Politécnica de Catalunya; España
Fil: Rodríguez Ferran, Antonio. Universidad Politécnica de Catalunya; España
Fil: Muñoz, Jose J. Universidad Politécnica de Catalunya; España
description This paper presents a cell-centred model for the simulation of planar and curved multicellular soft tissues. We propose a computational model that includes stress relaxation due to cell reorganisation (intercellular connectivity changes) and cytoskeleton remodelling (intracellular changes). Cells are represented by their cell centres, and their mechanical interaction is modelled through active non-linear elastic laws with a dynamically changing resting length. Special attention is paid to the handling of connectivity changes between cells, and the relaxation that the tissues exhibit under these topological changes. Cell–cell connectivity is computed by resorting to a Delaunay triangulation, which is combined with a mapping technique in order to obtain triangulations on curved manifolds. Our numerical results show that even a linear elastic cell–cell interaction model may induce a global non-linear response due to the reorganisation of the cell connectivity. This plastic-like behaviour is combined with a non-linear rheological law where the resting length depends on the elastic strain, mimicking the global visco-elastic response of tissues. The model is applied to simulate the elongation of planar and curved monolayers.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59686
Mosaffa, Payman; Asadipour, Nina; Millán, Raúl Daniel; Rodríguez Ferran, Antonio; Muñoz, Jose J; Cell-centred model for the simulation of curved cellular monolayers; Springer International Publishing; Computational Particle Mechanics; 2; 4; 12-2015; 359-370
2196-4386
2196-4378
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59686
identifier_str_mv Mosaffa, Payman; Asadipour, Nina; Millán, Raúl Daniel; Rodríguez Ferran, Antonio; Muñoz, Jose J; Cell-centred model for the simulation of curved cellular monolayers; Springer International Publishing; Computational Particle Mechanics; 2; 4; 12-2015; 359-370
2196-4386
2196-4378
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s40571-015-0043-x
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40571-015-0043-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer International Publishing
publisher.none.fl_str_mv Springer International Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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