Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic...

Autores
Rapacioli, Melina; Palma, Verónica; Flores, Domingo Vladimir
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The central nervous system areas displaying the highest structural and functional complexity correspond to the so called cortices, i.e. concentric alternating neuronal and fibrous layers. Corticogenesis, i.e. the development of the cortical organization, depends on the temporal-spatial organization of several developmental events: (a) the duration of the proliferative phase of the neuroepithelium, (b) the relative duration of symmetric (expansive) versus asymmetric (neuronogenic) sub phases, (c) the spatial organization of each kind of cell division, (e) the time of determination and cell cycle exit and (f) the time of onset of the post-mitotic neuronal migration and (g) the time of onset of the neuronal structural and functional differentiation. The first five events depend on molecular mechanisms that perform a fine tuning of the proliferative activity. Changes in any of them significantly influence the cortical size or volume (tangential expansion and radial thickness), morphology, architecture and also impact on neuritogenesis and synaptogenesis affecting the cortical wiring. This paper integrates information, obtained in several species, on the developmental roles of cell proliferation in the development of the optic tectum (OT) cortex, a multilayered associative area of the dorsal (alar) midbrain. The present review (1) compiles relevant information on the temporal and spatial organization of cell proliferation in different species (fish, amphibians, birds, and mammals), (2) revises the main molecular events involved in the isthmic organizer (IsO) determination and localization, (3) describes how the patterning installed by IsO is translated into spatially organized neural stem cell proliferation (i.e. by means of growth factors, receptors, transcription factors, signaling pathways, etc.) and (4) describes the morpho- and histogenetic effect of a spatially organized cell proliferation in the above mentioned species. A brief section on the OT evolution is also included. This section considers how the differential operation of cell proliferation could explain differences among species.
Fil: Rapacioli, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Fil: Palma, Verónica. Universidad de Chile; Chile
Fil: Flores, Domingo Vladimir. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Materia
CELL PROLIFERATION
CORTICOGENESIS
HISTOGENESIS
MORPHOGENESIS
PATTERNING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91401
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/91401
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex developmentRapacioli, MelinaPalma, VerónicaFlores, Domingo VladimirCELL PROLIFERATIONCORTICOGENESISHISTOGENESISMORPHOGENESISPATTERNINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The central nervous system areas displaying the highest structural and functional complexity correspond to the so called cortices, i.e. concentric alternating neuronal and fibrous layers. Corticogenesis, i.e. the development of the cortical organization, depends on the temporal-spatial organization of several developmental events: (a) the duration of the proliferative phase of the neuroepithelium, (b) the relative duration of symmetric (expansive) versus asymmetric (neuronogenic) sub phases, (c) the spatial organization of each kind of cell division, (e) the time of determination and cell cycle exit and (f) the time of onset of the post-mitotic neuronal migration and (g) the time of onset of the neuronal structural and functional differentiation. The first five events depend on molecular mechanisms that perform a fine tuning of the proliferative activity. Changes in any of them significantly influence the cortical size or volume (tangential expansion and radial thickness), morphology, architecture and also impact on neuritogenesis and synaptogenesis affecting the cortical wiring. This paper integrates information, obtained in several species, on the developmental roles of cell proliferation in the development of the optic tectum (OT) cortex, a multilayered associative area of the dorsal (alar) midbrain. The present review (1) compiles relevant information on the temporal and spatial organization of cell proliferation in different species (fish, amphibians, birds, and mammals), (2) revises the main molecular events involved in the isthmic organizer (IsO) determination and localization, (3) describes how the patterning installed by IsO is translated into spatially organized neural stem cell proliferation (i.e. by means of growth factors, receptors, transcription factors, signaling pathways, etc.) and (4) describes the morpho- and histogenetic effect of a spatially organized cell proliferation in the above mentioned species. A brief section on the OT evolution is also included. This section considers how the differential operation of cell proliferation could explain differences among species.Fil: Rapacioli, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; ArgentinaFil: Palma, Verónica. Universidad de Chile; ChileFil: Flores, Domingo Vladimir. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; ArgentinaFrontiers Research Foundation2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91401Rapacioli, Melina; Palma, Verónica; Flores, Domingo Vladimir; Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 10; 67; 3-2016; 1-211662-5102CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncel.2016.00067/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fncel.2016.00067info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:10:51Zoai:ri.conicet.gov.ar:11336/91401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:10:51.676CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
title Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
spellingShingle Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
Rapacioli, Melina
CELL PROLIFERATION
CORTICOGENESIS
HISTOGENESIS
MORPHOGENESIS
PATTERNING
title_short Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
title_full Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
title_fullStr Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
title_full_unstemmed Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
title_sort Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development
dc.creator.none.fl_str_mv Rapacioli, Melina
Palma, Verónica
Flores, Domingo Vladimir
author Rapacioli, Melina
author_facet Rapacioli, Melina
Palma, Verónica
Flores, Domingo Vladimir
author_role author
author2 Palma, Verónica
Flores, Domingo Vladimir
author2_role author
author
dc.subject.none.fl_str_mv CELL PROLIFERATION
CORTICOGENESIS
HISTOGENESIS
MORPHOGENESIS
PATTERNING
topic CELL PROLIFERATION
CORTICOGENESIS
HISTOGENESIS
MORPHOGENESIS
PATTERNING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The central nervous system areas displaying the highest structural and functional complexity correspond to the so called cortices, i.e. concentric alternating neuronal and fibrous layers. Corticogenesis, i.e. the development of the cortical organization, depends on the temporal-spatial organization of several developmental events: (a) the duration of the proliferative phase of the neuroepithelium, (b) the relative duration of symmetric (expansive) versus asymmetric (neuronogenic) sub phases, (c) the spatial organization of each kind of cell division, (e) the time of determination and cell cycle exit and (f) the time of onset of the post-mitotic neuronal migration and (g) the time of onset of the neuronal structural and functional differentiation. The first five events depend on molecular mechanisms that perform a fine tuning of the proliferative activity. Changes in any of them significantly influence the cortical size or volume (tangential expansion and radial thickness), morphology, architecture and also impact on neuritogenesis and synaptogenesis affecting the cortical wiring. This paper integrates information, obtained in several species, on the developmental roles of cell proliferation in the development of the optic tectum (OT) cortex, a multilayered associative area of the dorsal (alar) midbrain. The present review (1) compiles relevant information on the temporal and spatial organization of cell proliferation in different species (fish, amphibians, birds, and mammals), (2) revises the main molecular events involved in the isthmic organizer (IsO) determination and localization, (3) describes how the patterning installed by IsO is translated into spatially organized neural stem cell proliferation (i.e. by means of growth factors, receptors, transcription factors, signaling pathways, etc.) and (4) describes the morpho- and histogenetic effect of a spatially organized cell proliferation in the above mentioned species. A brief section on the OT evolution is also included. This section considers how the differential operation of cell proliferation could explain differences among species.
Fil: Rapacioli, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Fil: Palma, Verónica. Universidad de Chile; Chile
Fil: Flores, Domingo Vladimir. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
description The central nervous system areas displaying the highest structural and functional complexity correspond to the so called cortices, i.e. concentric alternating neuronal and fibrous layers. Corticogenesis, i.e. the development of the cortical organization, depends on the temporal-spatial organization of several developmental events: (a) the duration of the proliferative phase of the neuroepithelium, (b) the relative duration of symmetric (expansive) versus asymmetric (neuronogenic) sub phases, (c) the spatial organization of each kind of cell division, (e) the time of determination and cell cycle exit and (f) the time of onset of the post-mitotic neuronal migration and (g) the time of onset of the neuronal structural and functional differentiation. The first five events depend on molecular mechanisms that perform a fine tuning of the proliferative activity. Changes in any of them significantly influence the cortical size or volume (tangential expansion and radial thickness), morphology, architecture and also impact on neuritogenesis and synaptogenesis affecting the cortical wiring. This paper integrates information, obtained in several species, on the developmental roles of cell proliferation in the development of the optic tectum (OT) cortex, a multilayered associative area of the dorsal (alar) midbrain. The present review (1) compiles relevant information on the temporal and spatial organization of cell proliferation in different species (fish, amphibians, birds, and mammals), (2) revises the main molecular events involved in the isthmic organizer (IsO) determination and localization, (3) describes how the patterning installed by IsO is translated into spatially organized neural stem cell proliferation (i.e. by means of growth factors, receptors, transcription factors, signaling pathways, etc.) and (4) describes the morpho- and histogenetic effect of a spatially organized cell proliferation in the above mentioned species. A brief section on the OT evolution is also included. This section considers how the differential operation of cell proliferation could explain differences among species.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91401
Rapacioli, Melina; Palma, Verónica; Flores, Domingo Vladimir; Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 10; 67; 3-2016; 1-21
1662-5102
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91401
identifier_str_mv Rapacioli, Melina; Palma, Verónica; Flores, Domingo Vladimir; Morphogenetic and histogenetic roles of the temporal-spatial organization of cell proliferation in the vertebrate corticogenesis as revealed by inter-specific analyses of the optic tectum cortex development; Frontiers Research Foundation; Frontiers in Cellular Neuroscience; 10; 67; 3-2016; 1-21
1662-5102
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncel.2016.00067/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fncel.2016.00067
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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