Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study

Autores
Villalobos, Rafael; Ganem, Adriana; Cordero, Salomón; Vidales, Ana Maria; Domínguez, Armande
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The main objective of this work is to study the drug release behavior from inert matrix systems by using computer simulation. This study allowed us to propose a new statistical method to evaluate the drug percolation threshold as a function of the exposed surface area of the device. The matrix system was simulated as a simple cubic lattice. The sites of the lattice were randomly occupied at various drug-excipient ratios. By simulating a diffusive process, the drug was delivered from the matrix system. The obtained release profiles were fitted to two different models: near the excipient percolation threshold, the square root of the time was well fitted, whereas close to (but above) the drug percolation threshold, the power law described accurately the release data. A relationship between the initial drug load and the amount of drug trapped inside the matrix system at infinite time was found. This relationship was conveniently described by an error function. Percolation thresholds in the matrix systems were determined from the latter relationship by using a nonlinear regression method. The assessment of percolation thresholds depends on the exposed surface area of the matrix systems. Moreover, estimated percolation thresholds were in agreement with the predicted values stated in the percolation theory.
Fil: Villalobos, Rafael. Universidad Autónoma Metropolitana; México
Fil: Ganem, Adriana. Universidad Autónoma Metropolitana; México
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
Fil: Vidales, Ana Maria. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Domínguez, Armande. Universidad Autónoma Metropolitana; México
Materia
ANOMALOUS DIFFUSION
DRUG RELEASE
MATRIX SYSTEMS
MONTE CARLO SIMULATION
PERCOLATION THEORY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214004
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation studyVillalobos, RafaelGanem, AdrianaCordero, SalomónVidales, Ana MariaDomínguez, ArmandeANOMALOUS DIFFUSIONDRUG RELEASEMATRIX SYSTEMSMONTE CARLO SIMULATIONPERCOLATION THEORYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The main objective of this work is to study the drug release behavior from inert matrix systems by using computer simulation. This study allowed us to propose a new statistical method to evaluate the drug percolation threshold as a function of the exposed surface area of the device. The matrix system was simulated as a simple cubic lattice. The sites of the lattice were randomly occupied at various drug-excipient ratios. By simulating a diffusive process, the drug was delivered from the matrix system. The obtained release profiles were fitted to two different models: near the excipient percolation threshold, the square root of the time was well fitted, whereas close to (but above) the drug percolation threshold, the power law described accurately the release data. A relationship between the initial drug load and the amount of drug trapped inside the matrix system at infinite time was found. This relationship was conveniently described by an error function. Percolation thresholds in the matrix systems were determined from the latter relationship by using a nonlinear regression method. The assessment of percolation thresholds depends on the exposed surface area of the matrix systems. Moreover, estimated percolation thresholds were in agreement with the predicted values stated in the percolation theory.Fil: Villalobos, Rafael. Universidad Autónoma Metropolitana; MéxicoFil: Ganem, Adriana. Universidad Autónoma Metropolitana; MéxicoFil: Cordero, Salomón. Universidad Autónoma Metropolitana; MéxicoFil: Vidales, Ana Maria. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: Domínguez, Armande. Universidad Autónoma Metropolitana; MéxicoTaylor & Francis2005-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214004Villalobos, Rafael; Ganem, Adriana; Cordero, Salomón; Vidales, Ana Maria; Domínguez, Armande; Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study; Taylor & Francis; Drug Development and Industrial Pharmacy; 31; 6; 12-2005; 535-5430363-9045CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/03639040500215693info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/03639040500215693info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:52Zoai:ri.conicet.gov.ar:11336/214004instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:52.338CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
title Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
spellingShingle Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
Villalobos, Rafael
ANOMALOUS DIFFUSION
DRUG RELEASE
MATRIX SYSTEMS
MONTE CARLO SIMULATION
PERCOLATION THEORY
title_short Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
title_full Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
title_fullStr Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
title_full_unstemmed Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
title_sort Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study
dc.creator.none.fl_str_mv Villalobos, Rafael
Ganem, Adriana
Cordero, Salomón
Vidales, Ana Maria
Domínguez, Armande
author Villalobos, Rafael
author_facet Villalobos, Rafael
Ganem, Adriana
Cordero, Salomón
Vidales, Ana Maria
Domínguez, Armande
author_role author
author2 Ganem, Adriana
Cordero, Salomón
Vidales, Ana Maria
Domínguez, Armande
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANOMALOUS DIFFUSION
DRUG RELEASE
MATRIX SYSTEMS
MONTE CARLO SIMULATION
PERCOLATION THEORY
topic ANOMALOUS DIFFUSION
DRUG RELEASE
MATRIX SYSTEMS
MONTE CARLO SIMULATION
PERCOLATION THEORY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The main objective of this work is to study the drug release behavior from inert matrix systems by using computer simulation. This study allowed us to propose a new statistical method to evaluate the drug percolation threshold as a function of the exposed surface area of the device. The matrix system was simulated as a simple cubic lattice. The sites of the lattice were randomly occupied at various drug-excipient ratios. By simulating a diffusive process, the drug was delivered from the matrix system. The obtained release profiles were fitted to two different models: near the excipient percolation threshold, the square root of the time was well fitted, whereas close to (but above) the drug percolation threshold, the power law described accurately the release data. A relationship between the initial drug load and the amount of drug trapped inside the matrix system at infinite time was found. This relationship was conveniently described by an error function. Percolation thresholds in the matrix systems were determined from the latter relationship by using a nonlinear regression method. The assessment of percolation thresholds depends on the exposed surface area of the matrix systems. Moreover, estimated percolation thresholds were in agreement with the predicted values stated in the percolation theory.
Fil: Villalobos, Rafael. Universidad Autónoma Metropolitana; México
Fil: Ganem, Adriana. Universidad Autónoma Metropolitana; México
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
Fil: Vidales, Ana Maria. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Domínguez, Armande. Universidad Autónoma Metropolitana; México
description The main objective of this work is to study the drug release behavior from inert matrix systems by using computer simulation. This study allowed us to propose a new statistical method to evaluate the drug percolation threshold as a function of the exposed surface area of the device. The matrix system was simulated as a simple cubic lattice. The sites of the lattice were randomly occupied at various drug-excipient ratios. By simulating a diffusive process, the drug was delivered from the matrix system. The obtained release profiles were fitted to two different models: near the excipient percolation threshold, the square root of the time was well fitted, whereas close to (but above) the drug percolation threshold, the power law described accurately the release data. A relationship between the initial drug load and the amount of drug trapped inside the matrix system at infinite time was found. This relationship was conveniently described by an error function. Percolation thresholds in the matrix systems were determined from the latter relationship by using a nonlinear regression method. The assessment of percolation thresholds depends on the exposed surface area of the matrix systems. Moreover, estimated percolation thresholds were in agreement with the predicted values stated in the percolation theory.
publishDate 2005
dc.date.none.fl_str_mv 2005-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214004
Villalobos, Rafael; Ganem, Adriana; Cordero, Salomón; Vidales, Ana Maria; Domínguez, Armande; Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study; Taylor & Francis; Drug Development and Industrial Pharmacy; 31; 6; 12-2005; 535-543
0363-9045
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214004
identifier_str_mv Villalobos, Rafael; Ganem, Adriana; Cordero, Salomón; Vidales, Ana Maria; Domínguez, Armande; Effect of the drug-excipient ratio in matrix-type-controlled release systems: Computer simulation study; Taylor & Francis; Drug Development and Industrial Pharmacy; 31; 6; 12-2005; 535-543
0363-9045
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/03639040500215693
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/03639040500215693
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613540985438208
score 13.070432

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