One-dimensional drug release from finite Menger sponges: In silico simulation
- Autores
- Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.
Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; México
Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México
Fil: Ganem, Adriana. Universidad Nacional Autónoma de México; México
Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México - Materia
-
Menger sponge
Diffusion-controlled process
Drug release
Weibull function
Monte Carlo simulation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/137127
Ver los metadatos del registro completo
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One-dimensional drug release from finite Menger sponges: In silico simulationVillalobos, RafaelDomínguez, ArmandoGanem, AdrianaVidales, Ana MariaCordero, SalomónMenger spongeDiffusion-controlled processDrug releaseWeibull functionMonte Carlo simulationhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; MéxicoFil: Domínguez, Armando. Universidad Autónoma Metropolitana; MéxicoFil: Ganem, Adriana. Universidad Nacional Autónoma de México; MéxicoFil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: Cordero, Salomón. Universidad Autónoma Metropolitana; MéxicoPergamon-Elsevier Science Ltd2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/137127Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-28840960-0779CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960077909003671info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chaos.2009.04.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:36:13Zoai:ri.conicet.gov.ar:11336/137127instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:36:13.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| title |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| spellingShingle |
One-dimensional drug release from finite Menger sponges: In silico simulation Villalobos, Rafael Menger sponge Diffusion-controlled process Drug release Weibull function Monte Carlo simulation |
| title_short |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| title_full |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| title_fullStr |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| title_full_unstemmed |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| title_sort |
One-dimensional drug release from finite Menger sponges: In silico simulation |
| dc.creator.none.fl_str_mv |
Villalobos, Rafael Domínguez, Armando Ganem, Adriana Vidales, Ana Maria Cordero, Salomón |
| author |
Villalobos, Rafael |
| author_facet |
Villalobos, Rafael Domínguez, Armando Ganem, Adriana Vidales, Ana Maria Cordero, Salomón |
| author_role |
author |
| author2 |
Domínguez, Armando Ganem, Adriana Vidales, Ana Maria Cordero, Salomón |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Menger sponge Diffusion-controlled process Drug release Weibull function Monte Carlo simulation |
| topic |
Menger sponge Diffusion-controlled process Drug release Weibull function Monte Carlo simulation |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function. Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; México Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México Fil: Ganem, Adriana. Universidad Nacional Autónoma de México; México Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México |
| description |
The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-12 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
| status_str |
publishedVersion |
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http://hdl.handle.net/11336/137127 Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-2884 0960-0779 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/137127 |
| identifier_str_mv |
Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-2884 0960-0779 CONICET Digital CONICET |
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eng |
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eng |
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Pergamon-Elsevier Science Ltd |
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