One-dimensional drug release from finite Menger sponges: In silico simulation

Autores
Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.
Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; México
Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México
Fil: Ganem, Adriana. Universidad Nacional Autónoma de México; México
Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
Materia
Menger sponge
Diffusion-controlled process
Drug release
Weibull function
Monte Carlo simulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/137127
Acceder
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network_name_str CONICET Digital (CONICET)
spelling One-dimensional drug release from finite Menger sponges: In silico simulationVillalobos, RafaelDomínguez, ArmandoGanem, AdrianaVidales, Ana MariaCordero, SalomónMenger spongeDiffusion-controlled processDrug releaseWeibull functionMonte Carlo simulationhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; MéxicoFil: Domínguez, Armando. Universidad Autónoma Metropolitana; MéxicoFil: Ganem, Adriana. Universidad Nacional Autónoma de México; MéxicoFil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: Cordero, Salomón. Universidad Autónoma Metropolitana; MéxicoPergamon-Elsevier Science Ltd2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/137127Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-28840960-0779CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960077909003671info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chaos.2009.04.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:23Zoai:ri.conicet.gov.ar:11336/137127instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:23.574CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv One-dimensional drug release from finite Menger sponges: In silico simulation
title One-dimensional drug release from finite Menger sponges: In silico simulation
spellingShingle One-dimensional drug release from finite Menger sponges: In silico simulation
Villalobos, Rafael
Menger sponge
Diffusion-controlled process
Drug release
Weibull function
Monte Carlo simulation
title_short One-dimensional drug release from finite Menger sponges: In silico simulation
title_full One-dimensional drug release from finite Menger sponges: In silico simulation
title_fullStr One-dimensional drug release from finite Menger sponges: In silico simulation
title_full_unstemmed One-dimensional drug release from finite Menger sponges: In silico simulation
title_sort One-dimensional drug release from finite Menger sponges: In silico simulation
dc.creator.none.fl_str_mv Villalobos, Rafael
Domínguez, Armando
Ganem, Adriana
Vidales, Ana Maria
Cordero, Salomón
author Villalobos, Rafael
author_facet Villalobos, Rafael
Domínguez, Armando
Ganem, Adriana
Vidales, Ana Maria
Cordero, Salomón
author_role author
author2 Domínguez, Armando
Ganem, Adriana
Vidales, Ana Maria
Cordero, Salomón
author2_role author
author
author
author
dc.subject.none.fl_str_mv Menger sponge
Diffusion-controlled process
Drug release
Weibull function
Monte Carlo simulation
topic Menger sponge
Diffusion-controlled process
Drug release
Weibull function
Monte Carlo simulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.
Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; México
Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México
Fil: Ganem, Adriana. Universidad Nacional Autónoma de México; México
Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
description The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/137127
Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-2884
0960-0779
CONICET Digital
CONICET
url http://hdl.handle.net/11336/137127
identifier_str_mv Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-2884
0960-0779
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960077909003671
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chaos.2009.04.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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