Nonadaptive origin of interactome complexity
- Autores
- Fernandez, Ariel; Lynch , Michael
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina. University Of Chicago; Estados Unidos
Fil: Lynch , Michael. Indiana University; Estados Unidos - Materia
-
Interactome
Natural Selection - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/20225
Ver los metadatos del registro completo
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Nonadaptive origin of interactome complexityFernandez, ArielLynch , MichaelInteractomeNatural Selectionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms.Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina. University Of Chicago; Estados UnidosFil: Lynch , Michael. Indiana University; Estados UnidosNature Publishing Group2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20225Fernandez, Ariel; Lynch , Michael; Nonadaptive origin of interactome complexity; Nature Publishing Group; Nature; 474; 6-2011; 502-5050028-0836CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v474/n7352/full/nature09992.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nature09992info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:33Zoai:ri.conicet.gov.ar:11336/20225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:33.445CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Nonadaptive origin of interactome complexity |
title |
Nonadaptive origin of interactome complexity |
spellingShingle |
Nonadaptive origin of interactome complexity Fernandez, Ariel Interactome Natural Selection |
title_short |
Nonadaptive origin of interactome complexity |
title_full |
Nonadaptive origin of interactome complexity |
title_fullStr |
Nonadaptive origin of interactome complexity |
title_full_unstemmed |
Nonadaptive origin of interactome complexity |
title_sort |
Nonadaptive origin of interactome complexity |
dc.creator.none.fl_str_mv |
Fernandez, Ariel Lynch , Michael |
author |
Fernandez, Ariel |
author_facet |
Fernandez, Ariel Lynch , Michael |
author_role |
author |
author2 |
Lynch , Michael |
author2_role |
author |
dc.subject.none.fl_str_mv |
Interactome Natural Selection |
topic |
Interactome Natural Selection |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms. Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina. University Of Chicago; Estados Unidos Fil: Lynch , Michael. Indiana University; Estados Unidos |
description |
The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/20225 Fernandez, Ariel; Lynch , Michael; Nonadaptive origin of interactome complexity; Nature Publishing Group; Nature; 474; 6-2011; 502-505 0028-0836 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/20225 |
identifier_str_mv |
Fernandez, Ariel; Lynch , Michael; Nonadaptive origin of interactome complexity; Nature Publishing Group; Nature; 474; 6-2011; 502-505 0028-0836 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v474/n7352/full/nature09992.html info:eu-repo/semantics/altIdentifier/doi/10.1038/nature09992 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |