Nonadaptive origin of interactome complexity

Autores
Fernandez, Ariel; Lynch , Michael
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina. University Of Chicago; Estados Unidos
Fil: Lynch , Michael. Indiana University; Estados Unidos
Materia
Interactome
Natural Selection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20225

id CONICETDig_dae6f2926177a2f23b9a3eef469902cc
oai_identifier_str oai:ri.conicet.gov.ar:11336/20225
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nonadaptive origin of interactome complexityFernandez, ArielLynch , MichaelInteractomeNatural Selectionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms.Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina. University Of Chicago; Estados UnidosFil: Lynch , Michael. Indiana University; Estados UnidosNature Publishing Group2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20225Fernandez, Ariel; Lynch , Michael; Nonadaptive origin of interactome complexity; Nature Publishing Group; Nature; 474; 6-2011; 502-5050028-0836CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v474/n7352/full/nature09992.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nature09992info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:33Zoai:ri.conicet.gov.ar:11336/20225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:33.445CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nonadaptive origin of interactome complexity
title Nonadaptive origin of interactome complexity
spellingShingle Nonadaptive origin of interactome complexity
Fernandez, Ariel
Interactome
Natural Selection
title_short Nonadaptive origin of interactome complexity
title_full Nonadaptive origin of interactome complexity
title_fullStr Nonadaptive origin of interactome complexity
title_full_unstemmed Nonadaptive origin of interactome complexity
title_sort Nonadaptive origin of interactome complexity
dc.creator.none.fl_str_mv Fernandez, Ariel
Lynch , Michael
author Fernandez, Ariel
author_facet Fernandez, Ariel
Lynch , Michael
author_role author
author2 Lynch , Michael
author2_role author
dc.subject.none.fl_str_mv Interactome
Natural Selection
topic Interactome
Natural Selection
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina. University Of Chicago; Estados Unidos
Fil: Lynch , Michael. Indiana University; Estados Unidos
description The boundaries between prokaryotes, unicellular eukaryotes, and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift and mutation (1). The resultant decline in the efficiency of selection appears to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner (2). A key remaining question concerns the extent to which variation in the power of random genetic drift is capable of explaining phylogenetic diversity at the subcellular and cellular levels (2-4). Should this be the case, population size would have to be considered as a potential determinant of the mechanistic pathways responsible for long-term phenotypic evolution. Here we demonstrate a phylogenetically broad inverse relationship between the power of drift and the structural integrity of protein subunits. This leads to the hypothesis that the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein-protein interactions that stabilize key gene functions. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge by nonadaptive mechanisms.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20225
Fernandez, Ariel; Lynch , Michael; Nonadaptive origin of interactome complexity; Nature Publishing Group; Nature; 474; 6-2011; 502-505
0028-0836
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20225
identifier_str_mv Fernandez, Ariel; Lynch , Michael; Nonadaptive origin of interactome complexity; Nature Publishing Group; Nature; 474; 6-2011; 502-505
0028-0836
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v474/n7352/full/nature09992.html
info:eu-repo/semantics/altIdentifier/doi/10.1038/nature09992
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614446710784000
score 13.070432