Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives

Autores
Pallavicini, Carla; Gonzalez Vilas, Martina; Villarreal, Mirta Fabiana; Zamberlan, Federico; Muthukumaraswamy, Suresh D.; Nutt, David; Carhart Harris, Robin; Tagliazucchi, Enzo Rodolfo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by both classes of drugs, despite different pharmacological mechanisms of action. We investigated source-localized magnetoencephalography recordings to determine the frequency-specific changes in oscillatory activity and long-range functional coupling that are common to two serotonergic compounds (lysergic acid diethylamide [LSD] and psilocybin) and the NMDA-antagonist ketamine. Administration of the three drugs resulted in widespread and broadband spectral power reductions. We established their similarity by using different pairs of compounds to train and subsequently evaluate multivariate machine learning classifiers. After applying the same methodology to functional connectivity values, we observed a pattern of occipital, parietal and frontal decreases in the low alpha and theta bands that were specific to LSD and psilocybin, as well as decreases in the low beta band common to the three drugs. Our results represent a first effort in the direction of quantifying the similarity of large-scale brain activity patterns induced by drugs of different mechanism of action, confirming the link between changes in theta and alpha oscillations and 5-HT2A agonism, while also revealing the decoupling of activity in the beta band as an effect shared between NMDA antagonists and 5-HT2A agonists. We discuss how these frequency-specific convergences and divergences in the power and functional connectivity of brain oscillations might relate to the overlapping subjective effects of serotonergic psychedelics and glutamatergic dissociative compounds.
Fil: Pallavicini, Carla. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Gonzalez Vilas, Martina. Max Planck Institute For Empirical Aesthetics; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Muthukumaraswamy, Suresh D.. University of Auckland; Nueva Zelanda
Fil: Nutt, David. Center of Neuropsychopharmacology; Reino Unido
Fil: Carhart Harris, Robin. Center of Neuropsychopharmacology; Reino Unido
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Materia
CONSCIOUSNESS
DISSOCIATIVES
KETAMINE
MACHINE LEARNING
MAGNETOENCEPALOGRAPHY
SEROTONERGIC PSYCHEDELICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123298
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123298
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Spectral signatures of serotonergic psychedelics and glutamatergic dissociativesPallavicini, CarlaGonzalez Vilas, MartinaVillarreal, Mirta FabianaZamberlan, FedericoMuthukumaraswamy, Suresh D.Nutt, DavidCarhart Harris, RobinTagliazucchi, Enzo RodolfoCONSCIOUSNESSDISSOCIATIVESKETAMINEMACHINE LEARNINGMAGNETOENCEPALOGRAPHYSEROTONERGIC PSYCHEDELICShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by both classes of drugs, despite different pharmacological mechanisms of action. We investigated source-localized magnetoencephalography recordings to determine the frequency-specific changes in oscillatory activity and long-range functional coupling that are common to two serotonergic compounds (lysergic acid diethylamide [LSD] and psilocybin) and the NMDA-antagonist ketamine. Administration of the three drugs resulted in widespread and broadband spectral power reductions. We established their similarity by using different pairs of compounds to train and subsequently evaluate multivariate machine learning classifiers. After applying the same methodology to functional connectivity values, we observed a pattern of occipital, parietal and frontal decreases in the low alpha and theta bands that were specific to LSD and psilocybin, as well as decreases in the low beta band common to the three drugs. Our results represent a first effort in the direction of quantifying the similarity of large-scale brain activity patterns induced by drugs of different mechanism of action, confirming the link between changes in theta and alpha oscillations and 5-HT2A agonism, while also revealing the decoupling of activity in the beta band as an effect shared between NMDA antagonists and 5-HT2A agonists. We discuss how these frequency-specific convergences and divergences in the power and functional connectivity of brain oscillations might relate to the overlapping subjective effects of serotonergic psychedelics and glutamatergic dissociative compounds.Fil: Pallavicini, Carla. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Gonzalez Vilas, Martina. Max Planck Institute For Empirical Aesthetics; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Muthukumaraswamy, Suresh D.. University of Auckland; Nueva ZelandaFil: Nutt, David. Center of Neuropsychopharmacology; Reino UnidoFil: Carhart Harris, Robin. Center of Neuropsychopharmacology; Reino UnidoFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaElsevier2019-10-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123298Pallavicini, Carla; Gonzalez Vilas, Martina; Villarreal, Mirta Fabiana; Zamberlan, Federico; Muthukumaraswamy, Suresh D.; et al.; Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives; Elsevier; Journal Neuroimag; 200; 15-10-2019; 281-2911053-81191095-9572CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1053811919305506info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroimage.2019.06.053info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:34Zoai:ri.conicet.gov.ar:11336/123298instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:34.757CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
title Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
spellingShingle Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
Pallavicini, Carla
CONSCIOUSNESS
DISSOCIATIVES
KETAMINE
MACHINE LEARNING
MAGNETOENCEPALOGRAPHY
SEROTONERGIC PSYCHEDELICS
title_short Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
title_full Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
title_fullStr Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
title_full_unstemmed Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
title_sort Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
dc.creator.none.fl_str_mv Pallavicini, Carla
Gonzalez Vilas, Martina
Villarreal, Mirta Fabiana
Zamberlan, Federico
Muthukumaraswamy, Suresh D.
Nutt, David
Carhart Harris, Robin
Tagliazucchi, Enzo Rodolfo
author Pallavicini, Carla
author_facet Pallavicini, Carla
Gonzalez Vilas, Martina
Villarreal, Mirta Fabiana
Zamberlan, Federico
Muthukumaraswamy, Suresh D.
Nutt, David
Carhart Harris, Robin
Tagliazucchi, Enzo Rodolfo
author_role author
author2 Gonzalez Vilas, Martina
Villarreal, Mirta Fabiana
Zamberlan, Federico
Muthukumaraswamy, Suresh D.
Nutt, David
Carhart Harris, Robin
Tagliazucchi, Enzo Rodolfo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CONSCIOUSNESS
DISSOCIATIVES
KETAMINE
MACHINE LEARNING
MAGNETOENCEPALOGRAPHY
SEROTONERGIC PSYCHEDELICS
topic CONSCIOUSNESS
DISSOCIATIVES
KETAMINE
MACHINE LEARNING
MAGNETOENCEPALOGRAPHY
SEROTONERGIC PSYCHEDELICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by both classes of drugs, despite different pharmacological mechanisms of action. We investigated source-localized magnetoencephalography recordings to determine the frequency-specific changes in oscillatory activity and long-range functional coupling that are common to two serotonergic compounds (lysergic acid diethylamide [LSD] and psilocybin) and the NMDA-antagonist ketamine. Administration of the three drugs resulted in widespread and broadband spectral power reductions. We established their similarity by using different pairs of compounds to train and subsequently evaluate multivariate machine learning classifiers. After applying the same methodology to functional connectivity values, we observed a pattern of occipital, parietal and frontal decreases in the low alpha and theta bands that were specific to LSD and psilocybin, as well as decreases in the low beta band common to the three drugs. Our results represent a first effort in the direction of quantifying the similarity of large-scale brain activity patterns induced by drugs of different mechanism of action, confirming the link between changes in theta and alpha oscillations and 5-HT2A agonism, while also revealing the decoupling of activity in the beta band as an effect shared between NMDA antagonists and 5-HT2A agonists. We discuss how these frequency-specific convergences and divergences in the power and functional connectivity of brain oscillations might relate to the overlapping subjective effects of serotonergic psychedelics and glutamatergic dissociative compounds.
Fil: Pallavicini, Carla. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Gonzalez Vilas, Martina. Max Planck Institute For Empirical Aesthetics; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Muthukumaraswamy, Suresh D.. University of Auckland; Nueva Zelanda
Fil: Nutt, David. Center of Neuropsychopharmacology; Reino Unido
Fil: Carhart Harris, Robin. Center of Neuropsychopharmacology; Reino Unido
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
description Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by both classes of drugs, despite different pharmacological mechanisms of action. We investigated source-localized magnetoencephalography recordings to determine the frequency-specific changes in oscillatory activity and long-range functional coupling that are common to two serotonergic compounds (lysergic acid diethylamide [LSD] and psilocybin) and the NMDA-antagonist ketamine. Administration of the three drugs resulted in widespread and broadband spectral power reductions. We established their similarity by using different pairs of compounds to train and subsequently evaluate multivariate machine learning classifiers. After applying the same methodology to functional connectivity values, we observed a pattern of occipital, parietal and frontal decreases in the low alpha and theta bands that were specific to LSD and psilocybin, as well as decreases in the low beta band common to the three drugs. Our results represent a first effort in the direction of quantifying the similarity of large-scale brain activity patterns induced by drugs of different mechanism of action, confirming the link between changes in theta and alpha oscillations and 5-HT2A agonism, while also revealing the decoupling of activity in the beta band as an effect shared between NMDA antagonists and 5-HT2A agonists. We discuss how these frequency-specific convergences and divergences in the power and functional connectivity of brain oscillations might relate to the overlapping subjective effects of serotonergic psychedelics and glutamatergic dissociative compounds.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123298
Pallavicini, Carla; Gonzalez Vilas, Martina; Villarreal, Mirta Fabiana; Zamberlan, Federico; Muthukumaraswamy, Suresh D.; et al.; Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives; Elsevier; Journal Neuroimag; 200; 15-10-2019; 281-291
1053-8119
1095-9572
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123298
identifier_str_mv Pallavicini, Carla; Gonzalez Vilas, Martina; Villarreal, Mirta Fabiana; Zamberlan, Federico; Muthukumaraswamy, Suresh D.; et al.; Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives; Elsevier; Journal Neuroimag; 200; 15-10-2019; 281-291
1053-8119
1095-9572
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1053811919305506
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroimage.2019.06.053
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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