Human brain effects of DMT assessed via EEG-fMRI

Autores
Timmermann, Christopher; Roseman, Leor; Haridas, Sharad; Rosas, Fernando E.; Luan, Lisa; Kettner, Hannes; Martell, Jonny; Erritzoe, David; Tagliazucchi, Enzo Rodolfo; Pallavicini, Carla; Girn, Manesh; Alamia, Andrea; Leech, Robert; Nutt, David J.; Carhart-Harris, Robin L.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-subjects, placebo-controlled design, we acquired multimodal neuroimaging [i.e., EEG-fMRI (electroencephalography-functional MRI)] data to assess the effects of intravenous (IV) N,N-Dimethyltryptamine (DMT) on brain function in 20 healthy volunteers. Simultaneous EEG-fMRI was acquired prior to, during, and after a bolus IV administration of 20 mg DMT, and, separately, placebo. At dosages consistent with the present study, DMT, a serotonin 2A receptor (5-HT2AR) agonist, induces a deeply immersive and radically altered state of consciousness. DMT is thus a useful research tool for probing the neural correlates of conscious experience. Here, fMRI results revealed robust increases in global functional connectivity (GFC), network disintegration and desegregation, and a compression of the principal cortical gradient under DMT. GFC × subjective intensity maps correlated with independent positron emission tomography (PET)-derived 5-HT2AR maps, and both overlapped with meta-analytical data implying human-specific psychological functions. Changes in major EEG-measured neurophysiological properties correlated with specific changes in various fMRI metrics, enriching our understanding of the neural basis of DMT's effects. The present findings advance on previous work by confirming a predominant action of DMT - and likely other 5-HT2AR agonist psychedelics - on the brain's transmodal association pole, i.e., the neurodevelopmentally and evolutionarily recent cortex that is associated with species-specific psychological advancements, and high expression of 5-HT2A receptors.
Fil: Timmermann, Christopher. Imperial College London; Reino Unido
Fil: Roseman, Leor. Imperial College London; Reino Unido
Fil: Haridas, Sharad. Imperial College London; Reino Unido
Fil: Rosas, Fernando E.. University of Sussex; Reino Unido. University of Oxford; Reino Unido. Imperial College London; Reino Unido
Fil: Luan, Lisa. Imperial College London; Reino Unido
Fil: Kettner, Hannes. Imperial College London; Reino Unido
Fil: Martell, Jonny. Imperial College London; Reino Unido
Fil: Erritzoe, David. Imperial College London; Reino Unido
Fil: Tagliazucchi, Enzo Rodolfo. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Pallavicini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Girn, Manesh. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Alamia, Andrea. Université Fédérale Toulouse; Francia
Fil: Leech, Robert. King's College London; Reino Unido
Fil: Nutt, David J.. Imperial College London; Reino Unido
Fil: Carhart-Harris, Robin L.. Imperial College London; Reino Unido. University of California; Estados Unidos
Materia
AYAHUASCA
CONSCIOUSNESS
DIMETHYLTRYPTAMINE
PSYCHEDELICS
SEROTONIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228617
Acceder
id CONICETDig_89adcf10c235bf25a7227947b602e35e
oai_identifier_str oai:ri.conicet.gov.ar:11336/228617
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human brain effects of DMT assessed via EEG-fMRITimmermann, ChristopherRoseman, LeorHaridas, SharadRosas, Fernando E.Luan, LisaKettner, HannesMartell, JonnyErritzoe, DavidTagliazucchi, Enzo RodolfoPallavicini, CarlaGirn, ManeshAlamia, AndreaLeech, RobertNutt, David J.Carhart-Harris, Robin L.AYAHUASCACONSCIOUSNESSDIMETHYLTRYPTAMINEPSYCHEDELICSSEROTONINhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-subjects, placebo-controlled design, we acquired multimodal neuroimaging [i.e., EEG-fMRI (electroencephalography-functional MRI)] data to assess the effects of intravenous (IV) N,N-Dimethyltryptamine (DMT) on brain function in 20 healthy volunteers. Simultaneous EEG-fMRI was acquired prior to, during, and after a bolus IV administration of 20 mg DMT, and, separately, placebo. At dosages consistent with the present study, DMT, a serotonin 2A receptor (5-HT2AR) agonist, induces a deeply immersive and radically altered state of consciousness. DMT is thus a useful research tool for probing the neural correlates of conscious experience. Here, fMRI results revealed robust increases in global functional connectivity (GFC), network disintegration and desegregation, and a compression of the principal cortical gradient under DMT. GFC × subjective intensity maps correlated with independent positron emission tomography (PET)-derived 5-HT2AR maps, and both overlapped with meta-analytical data implying human-specific psychological functions. Changes in major EEG-measured neurophysiological properties correlated with specific changes in various fMRI metrics, enriching our understanding of the neural basis of DMT's effects. The present findings advance on previous work by confirming a predominant action of DMT - and likely other 5-HT2AR agonist psychedelics - on the brain's transmodal association pole, i.e., the neurodevelopmentally and evolutionarily recent cortex that is associated with species-specific psychological advancements, and high expression of 5-HT2A receptors.Fil: Timmermann, Christopher. Imperial College London; Reino UnidoFil: Roseman, Leor. Imperial College London; Reino UnidoFil: Haridas, Sharad. Imperial College London; Reino UnidoFil: Rosas, Fernando E.. University of Sussex; Reino Unido. University of Oxford; Reino Unido. Imperial College London; Reino UnidoFil: Luan, Lisa. Imperial College London; Reino UnidoFil: Kettner, Hannes. Imperial College London; Reino UnidoFil: Martell, Jonny. Imperial College London; Reino UnidoFil: Erritzoe, David. Imperial College London; Reino UnidoFil: Tagliazucchi, Enzo Rodolfo. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Pallavicini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Girn, Manesh. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Alamia, Andrea. Université Fédérale Toulouse; FranciaFil: Leech, Robert. King's College London; Reino UnidoFil: Nutt, David J.. Imperial College London; Reino UnidoFil: Carhart-Harris, Robin L.. Imperial College London; Reino Unido. University of California; Estados UnidosNational Academy of Sciences2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228617Timmermann, Christopher; Roseman, Leor; Haridas, Sharad; Rosas, Fernando E.; Luan, Lisa; et al.; Human brain effects of DMT assessed via EEG-fMRI; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 120; 13; 3-2023; 1-120027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2218949120info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/10.1073/pnas.2218949120info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:21Zoai:ri.conicet.gov.ar:11336/228617instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:21.221CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human brain effects of DMT assessed via EEG-fMRI
title Human brain effects of DMT assessed via EEG-fMRI
spellingShingle Human brain effects of DMT assessed via EEG-fMRI
Timmermann, Christopher
AYAHUASCA
CONSCIOUSNESS
DIMETHYLTRYPTAMINE
PSYCHEDELICS
SEROTONIN
title_short Human brain effects of DMT assessed via EEG-fMRI
title_full Human brain effects of DMT assessed via EEG-fMRI
title_fullStr Human brain effects of DMT assessed via EEG-fMRI
title_full_unstemmed Human brain effects of DMT assessed via EEG-fMRI
title_sort Human brain effects of DMT assessed via EEG-fMRI
dc.creator.none.fl_str_mv Timmermann, Christopher
Roseman, Leor
Haridas, Sharad
Rosas, Fernando E.
Luan, Lisa
Kettner, Hannes
Martell, Jonny
Erritzoe, David
Tagliazucchi, Enzo Rodolfo
Pallavicini, Carla
Girn, Manesh
Alamia, Andrea
Leech, Robert
Nutt, David J.
Carhart-Harris, Robin L.
author Timmermann, Christopher
author_facet Timmermann, Christopher
Roseman, Leor
Haridas, Sharad
Rosas, Fernando E.
Luan, Lisa
Kettner, Hannes
Martell, Jonny
Erritzoe, David
Tagliazucchi, Enzo Rodolfo
Pallavicini, Carla
Girn, Manesh
Alamia, Andrea
Leech, Robert
Nutt, David J.
Carhart-Harris, Robin L.
author_role author
author2 Roseman, Leor
Haridas, Sharad
Rosas, Fernando E.
Luan, Lisa
Kettner, Hannes
Martell, Jonny
Erritzoe, David
Tagliazucchi, Enzo Rodolfo
Pallavicini, Carla
Girn, Manesh
Alamia, Andrea
Leech, Robert
Nutt, David J.
Carhart-Harris, Robin L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AYAHUASCA
CONSCIOUSNESS
DIMETHYLTRYPTAMINE
PSYCHEDELICS
SEROTONIN
topic AYAHUASCA
CONSCIOUSNESS
DIMETHYLTRYPTAMINE
PSYCHEDELICS
SEROTONIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-subjects, placebo-controlled design, we acquired multimodal neuroimaging [i.e., EEG-fMRI (electroencephalography-functional MRI)] data to assess the effects of intravenous (IV) N,N-Dimethyltryptamine (DMT) on brain function in 20 healthy volunteers. Simultaneous EEG-fMRI was acquired prior to, during, and after a bolus IV administration of 20 mg DMT, and, separately, placebo. At dosages consistent with the present study, DMT, a serotonin 2A receptor (5-HT2AR) agonist, induces a deeply immersive and radically altered state of consciousness. DMT is thus a useful research tool for probing the neural correlates of conscious experience. Here, fMRI results revealed robust increases in global functional connectivity (GFC), network disintegration and desegregation, and a compression of the principal cortical gradient under DMT. GFC × subjective intensity maps correlated with independent positron emission tomography (PET)-derived 5-HT2AR maps, and both overlapped with meta-analytical data implying human-specific psychological functions. Changes in major EEG-measured neurophysiological properties correlated with specific changes in various fMRI metrics, enriching our understanding of the neural basis of DMT's effects. The present findings advance on previous work by confirming a predominant action of DMT - and likely other 5-HT2AR agonist psychedelics - on the brain's transmodal association pole, i.e., the neurodevelopmentally and evolutionarily recent cortex that is associated with species-specific psychological advancements, and high expression of 5-HT2A receptors.
Fil: Timmermann, Christopher. Imperial College London; Reino Unido
Fil: Roseman, Leor. Imperial College London; Reino Unido
Fil: Haridas, Sharad. Imperial College London; Reino Unido
Fil: Rosas, Fernando E.. University of Sussex; Reino Unido. University of Oxford; Reino Unido. Imperial College London; Reino Unido
Fil: Luan, Lisa. Imperial College London; Reino Unido
Fil: Kettner, Hannes. Imperial College London; Reino Unido
Fil: Martell, Jonny. Imperial College London; Reino Unido
Fil: Erritzoe, David. Imperial College London; Reino Unido
Fil: Tagliazucchi, Enzo Rodolfo. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Pallavicini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Girn, Manesh. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Alamia, Andrea. Université Fédérale Toulouse; Francia
Fil: Leech, Robert. King's College London; Reino Unido
Fil: Nutt, David J.. Imperial College London; Reino Unido
Fil: Carhart-Harris, Robin L.. Imperial College London; Reino Unido. University of California; Estados Unidos
description Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-subjects, placebo-controlled design, we acquired multimodal neuroimaging [i.e., EEG-fMRI (electroencephalography-functional MRI)] data to assess the effects of intravenous (IV) N,N-Dimethyltryptamine (DMT) on brain function in 20 healthy volunteers. Simultaneous EEG-fMRI was acquired prior to, during, and after a bolus IV administration of 20 mg DMT, and, separately, placebo. At dosages consistent with the present study, DMT, a serotonin 2A receptor (5-HT2AR) agonist, induces a deeply immersive and radically altered state of consciousness. DMT is thus a useful research tool for probing the neural correlates of conscious experience. Here, fMRI results revealed robust increases in global functional connectivity (GFC), network disintegration and desegregation, and a compression of the principal cortical gradient under DMT. GFC × subjective intensity maps correlated with independent positron emission tomography (PET)-derived 5-HT2AR maps, and both overlapped with meta-analytical data implying human-specific psychological functions. Changes in major EEG-measured neurophysiological properties correlated with specific changes in various fMRI metrics, enriching our understanding of the neural basis of DMT's effects. The present findings advance on previous work by confirming a predominant action of DMT - and likely other 5-HT2AR agonist psychedelics - on the brain's transmodal association pole, i.e., the neurodevelopmentally and evolutionarily recent cortex that is associated with species-specific psychological advancements, and high expression of 5-HT2A receptors.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228617
Timmermann, Christopher; Roseman, Leor; Haridas, Sharad; Rosas, Fernando E.; Luan, Lisa; et al.; Human brain effects of DMT assessed via EEG-fMRI; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 120; 13; 3-2023; 1-12
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228617
identifier_str_mv Timmermann, Christopher; Roseman, Leor; Haridas, Sharad; Rosas, Fernando E.; Luan, Lisa; et al.; Human brain effects of DMT assessed via EEG-fMRI; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 120; 13; 3-2023; 1-12
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2218949120
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/10.1073/pnas.2218949120
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613276856483840
score 13.070432

Publicaciones similares