Effects of classic psychedelic drugs on turbulent signatures in brain dynamics

Autores
Cruzat, Josephine; Sanz Perl Hernandez, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; Roseman, Leor; Luppi, Andrea; Ibañez, Agustin Mariano; Nutt, David; Carhart Harris, Robin; Tagliazucchi, Enzo Rodolfo; Deco, Gustavo; Kringelbach, Morten
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain’s functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., “compress”) the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.
Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile. Universitat Pompeu Fabra; España. University of Oxford; Reino Unido
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Escrichs, Anira. Universitat Pompeu Fabra; España
Fil: Vohryzek, Jakub. Universitat Pompeu Fabra; España. University of Oxford; Reino Unido
Fil: Timmermann, Christopher. Imperial College London; Reino Unido
Fil: Roseman, Leor. Imperial College London; Reino Unido
Fil: Luppi, Andrea. University of Cambridge; Reino Unido. The Alan Turing Institute; Reino Unido
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda
Fil: Nutt, David. Imperial College London; Reino Unido
Fil: Carhart Harris, Robin. Imperial College London; Reino Unido. University of California; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de la Recerca i Estudis Avancats; España. Max Planck Institute for Human Cognitive and Brain Sciences; Alemania. Monash University; Australia
Fil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; Dinamarca
Materia
Psychedelics
Consciousness
Turbulence
Dynamics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214792
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Effects of classic psychedelic drugs on turbulent signatures in brain dynamicsCruzat, JosephineSanz Perl Hernandez, YonatanEscrichs, AniraVohryzek, JakubTimmermann, ChristopherRoseman, LeorLuppi, AndreaIbañez, Agustin MarianoNutt, DavidCarhart Harris, RobinTagliazucchi, Enzo RodolfoDeco, GustavoKringelbach, MortenPsychedelicsConsciousnessTurbulenceDynamicshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain’s functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., “compress”) the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile. Universitat Pompeu Fabra; España. University of Oxford; Reino UnidoFil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Escrichs, Anira. Universitat Pompeu Fabra; EspañaFil: Vohryzek, Jakub. Universitat Pompeu Fabra; España. University of Oxford; Reino UnidoFil: Timmermann, Christopher. Imperial College London; Reino UnidoFil: Roseman, Leor. Imperial College London; Reino UnidoFil: Luppi, Andrea. University of Cambridge; Reino Unido. The Alan Turing Institute; Reino UnidoFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; IrlandaFil: Nutt, David. Imperial College London; Reino UnidoFil: Carhart Harris, Robin. Imperial College London; Reino Unido. University of California; Estados UnidosFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; ChileFil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de la Recerca i Estudis Avancats; España. Max Planck Institute for Human Cognitive and Brain Sciences; Alemania. Monash University; AustraliaFil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; DinamarcaMassachusetts Institute of Technology2022-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214792Cruzat, Josephine; Sanz Perl Hernandez, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; et al.; Effects of classic psychedelic drugs on turbulent signatures in brain dynamics; Massachusetts Institute of Technology; Network Neuroscience; 6; 4; 4-2022; 1104-11242472-1751CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://direct.mit.edu/netn/article/6/4/1104/110445/Effects-of-classic-psychedelic-drugs-on-turbulentinfo:eu-repo/semantics/altIdentifier/doi/10.1162/netn_a_00250info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:19Zoai:ri.conicet.gov.ar:11336/214792instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:19.709CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
title Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
spellingShingle Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
Cruzat, Josephine
Psychedelics
Consciousness
Turbulence
Dynamics
title_short Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
title_full Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
title_fullStr Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
title_full_unstemmed Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
title_sort Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
dc.creator.none.fl_str_mv Cruzat, Josephine
Sanz Perl Hernandez, Yonatan
Escrichs, Anira
Vohryzek, Jakub
Timmermann, Christopher
Roseman, Leor
Luppi, Andrea
Ibañez, Agustin Mariano
Nutt, David
Carhart Harris, Robin
Tagliazucchi, Enzo Rodolfo
Deco, Gustavo
Kringelbach, Morten
author Cruzat, Josephine
author_facet Cruzat, Josephine
Sanz Perl Hernandez, Yonatan
Escrichs, Anira
Vohryzek, Jakub
Timmermann, Christopher
Roseman, Leor
Luppi, Andrea
Ibañez, Agustin Mariano
Nutt, David
Carhart Harris, Robin
Tagliazucchi, Enzo Rodolfo
Deco, Gustavo
Kringelbach, Morten
author_role author
author2 Sanz Perl Hernandez, Yonatan
Escrichs, Anira
Vohryzek, Jakub
Timmermann, Christopher
Roseman, Leor
Luppi, Andrea
Ibañez, Agustin Mariano
Nutt, David
Carhart Harris, Robin
Tagliazucchi, Enzo Rodolfo
Deco, Gustavo
Kringelbach, Morten
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psychedelics
Consciousness
Turbulence
Dynamics
topic Psychedelics
Consciousness
Turbulence
Dynamics
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain’s functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., “compress”) the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.
Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile. Universitat Pompeu Fabra; España. University of Oxford; Reino Unido
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Escrichs, Anira. Universitat Pompeu Fabra; España
Fil: Vohryzek, Jakub. Universitat Pompeu Fabra; España. University of Oxford; Reino Unido
Fil: Timmermann, Christopher. Imperial College London; Reino Unido
Fil: Roseman, Leor. Imperial College London; Reino Unido
Fil: Luppi, Andrea. University of Cambridge; Reino Unido. The Alan Turing Institute; Reino Unido
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda
Fil: Nutt, David. Imperial College London; Reino Unido
Fil: Carhart Harris, Robin. Imperial College London; Reino Unido. University of California; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de la Recerca i Estudis Avancats; España. Max Planck Institute for Human Cognitive and Brain Sciences; Alemania. Monash University; Australia
Fil: Kringelbach, Morten. University of Oxford; Reino Unido. University Aarhus; Dinamarca
description Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain’s functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., “compress”) the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.
publishDate 2022
dc.date.none.fl_str_mv 2022-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214792
Cruzat, Josephine; Sanz Perl Hernandez, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; et al.; Effects of classic psychedelic drugs on turbulent signatures in brain dynamics; Massachusetts Institute of Technology; Network Neuroscience; 6; 4; 4-2022; 1104-1124
2472-1751
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214792
identifier_str_mv Cruzat, Josephine; Sanz Perl Hernandez, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; et al.; Effects of classic psychedelic drugs on turbulent signatures in brain dynamics; Massachusetts Institute of Technology; Network Neuroscience; 6; 4; 4-2022; 1104-1124
2472-1751
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://direct.mit.edu/netn/article/6/4/1104/110445/Effects-of-classic-psychedelic-drugs-on-turbulent
info:eu-repo/semantics/altIdentifier/doi/10.1162/netn_a_00250
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Massachusetts Institute of Technology
publisher.none.fl_str_mv Massachusetts Institute of Technology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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