Role of astrocytes in the immune-circadian signaling

Autores
Duhart, José Manuel; Marpegan, Luciano; Leone, Maria Juliana; Golombek, Diego Andrés
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The mammalian circadian system controls biological rhythms by means of a central biological clock located in the suprachiasmatic nuclei (SCN) as well as diverse peripheral oscillators located throughout the body. Besides entrainment by the environment, rhythmic nervous and humoral factors are able to stimulate the clock and therefore close a feedback loop that fine-tunes the system. Among such factors, the immune system is clearly regulated by the circadian clock, with both cellular and humoral components experiencing daily rhythms in different tissues. We propose that immune factors are able to modulate the SCN and affect the phase of the oscillator. In addition, taking into account that astrocytes respond to cytokines and chemokines and might also secrete such molecules, as well as express immune-like receptors, we suggest that glial cells of the central nervous system play a key role as an interface between the immune and the circadian systems. The circadian modulation of the immune system opens a new perspective for the understanding of not only the origins of disease but also of physiological regulation of body functions. Conversely, immune factors are now being recognized as clock regulators, and astrocytes provide a link for such communication, adding another role to an increasing list of glial functions.
Fil: Duhart, José Manuel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leone, Maria Juliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Circadian Rhythms
Suprachiasmatic Nuclei
Astrocytes
Immune System
Cytokines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28291
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/28291
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of astrocytes in the immune-circadian signalingDuhart, José ManuelMarpegan, LucianoLeone, Maria JulianaGolombek, Diego AndrésCircadian RhythmsSuprachiasmatic NucleiAstrocytesImmune SystemCytokineshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The mammalian circadian system controls biological rhythms by means of a central biological clock located in the suprachiasmatic nuclei (SCN) as well as diverse peripheral oscillators located throughout the body. Besides entrainment by the environment, rhythmic nervous and humoral factors are able to stimulate the clock and therefore close a feedback loop that fine-tunes the system. Among such factors, the immune system is clearly regulated by the circadian clock, with both cellular and humoral components experiencing daily rhythms in different tissues. We propose that immune factors are able to modulate the SCN and affect the phase of the oscillator. In addition, taking into account that astrocytes respond to cytokines and chemokines and might also secrete such molecules, as well as express immune-like receptors, we suggest that glial cells of the central nervous system play a key role as an interface between the immune and the circadian systems. The circadian modulation of the immune system opens a new perspective for the understanding of not only the origins of disease but also of physiological regulation of body functions. Conversely, immune factors are now being recognized as clock regulators, and astrocytes provide a link for such communication, adding another role to an increasing list of glial functions.Fil: Duhart, José Manuel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Leone, Maria Juliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaIOS Press2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28291Duhart, José Manuel; Marpegan, Luciano; Leone, Maria Juliana; Golombek, Diego Andrés; Role of astrocytes in the immune-circadian signaling; IOS Press; Advances in Neuroimmune Biology; 4; 2; 10-2013; 85-961878-948XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/advances-in-neuroimmune-biology/nib130058info:eu-repo/semantics/altIdentifier/doi/10.3233/NIB-130058info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:13Zoai:ri.conicet.gov.ar:11336/28291instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:14.129CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of astrocytes in the immune-circadian signaling
title Role of astrocytes in the immune-circadian signaling
spellingShingle Role of astrocytes in the immune-circadian signaling
Duhart, José Manuel
Circadian Rhythms
Suprachiasmatic Nuclei
Astrocytes
Immune System
Cytokines
title_short Role of astrocytes in the immune-circadian signaling
title_full Role of astrocytes in the immune-circadian signaling
title_fullStr Role of astrocytes in the immune-circadian signaling
title_full_unstemmed Role of astrocytes in the immune-circadian signaling
title_sort Role of astrocytes in the immune-circadian signaling
dc.creator.none.fl_str_mv Duhart, José Manuel
Marpegan, Luciano
Leone, Maria Juliana
Golombek, Diego Andrés
author Duhart, José Manuel
author_facet Duhart, José Manuel
Marpegan, Luciano
Leone, Maria Juliana
Golombek, Diego Andrés
author_role author
author2 Marpegan, Luciano
Leone, Maria Juliana
Golombek, Diego Andrés
author2_role author
author
author
dc.subject.none.fl_str_mv Circadian Rhythms
Suprachiasmatic Nuclei
Astrocytes
Immune System
Cytokines
topic Circadian Rhythms
Suprachiasmatic Nuclei
Astrocytes
Immune System
Cytokines
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The mammalian circadian system controls biological rhythms by means of a central biological clock located in the suprachiasmatic nuclei (SCN) as well as diverse peripheral oscillators located throughout the body. Besides entrainment by the environment, rhythmic nervous and humoral factors are able to stimulate the clock and therefore close a feedback loop that fine-tunes the system. Among such factors, the immune system is clearly regulated by the circadian clock, with both cellular and humoral components experiencing daily rhythms in different tissues. We propose that immune factors are able to modulate the SCN and affect the phase of the oscillator. In addition, taking into account that astrocytes respond to cytokines and chemokines and might also secrete such molecules, as well as express immune-like receptors, we suggest that glial cells of the central nervous system play a key role as an interface between the immune and the circadian systems. The circadian modulation of the immune system opens a new perspective for the understanding of not only the origins of disease but also of physiological regulation of body functions. Conversely, immune factors are now being recognized as clock regulators, and astrocytes provide a link for such communication, adding another role to an increasing list of glial functions.
Fil: Duhart, José Manuel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leone, Maria Juliana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The mammalian circadian system controls biological rhythms by means of a central biological clock located in the suprachiasmatic nuclei (SCN) as well as diverse peripheral oscillators located throughout the body. Besides entrainment by the environment, rhythmic nervous and humoral factors are able to stimulate the clock and therefore close a feedback loop that fine-tunes the system. Among such factors, the immune system is clearly regulated by the circadian clock, with both cellular and humoral components experiencing daily rhythms in different tissues. We propose that immune factors are able to modulate the SCN and affect the phase of the oscillator. In addition, taking into account that astrocytes respond to cytokines and chemokines and might also secrete such molecules, as well as express immune-like receptors, we suggest that glial cells of the central nervous system play a key role as an interface between the immune and the circadian systems. The circadian modulation of the immune system opens a new perspective for the understanding of not only the origins of disease but also of physiological regulation of body functions. Conversely, immune factors are now being recognized as clock regulators, and astrocytes provide a link for such communication, adding another role to an increasing list of glial functions.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28291
Duhart, José Manuel; Marpegan, Luciano; Leone, Maria Juliana; Golombek, Diego Andrés; Role of astrocytes in the immune-circadian signaling; IOS Press; Advances in Neuroimmune Biology; 4; 2; 10-2013; 85-96
1878-948X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28291
identifier_str_mv Duhart, José Manuel; Marpegan, Luciano; Leone, Maria Juliana; Golombek, Diego Andrés; Role of astrocytes in the immune-circadian signaling; IOS Press; Advances in Neuroimmune Biology; 4; 2; 10-2013; 85-96
1878-948X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/advances-in-neuroimmune-biology/nib130058
info:eu-repo/semantics/altIdentifier/doi/10.3233/NIB-130058
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269272551718912
score 13.13397

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