The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment

Autores
Bussi, Ivana Leda; Ben Hamo, Miriam; Salazar Leon, Luis E.; Casiraghi, Leandro Pablo; Zhang, Victor Y.; Neitz, Alexandra F.; Lee, Jeffrey; Takahashi, Joseph S.; Kim, Jeansok J.; de la Iglesia, Horacio Oscar
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear-entrained clock, and provide a mechanistic insight into this clock.
Fil: Bussi, Ivana Leda. University of Washington; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ben Hamo, Miriam. University of Washington; Estados Unidos
Fil: Salazar Leon, Luis E.. University of Washington; Estados Unidos
Fil: Casiraghi, Leandro Pablo. University of Washington; Estados Unidos. Universidad de San Andrés. Escuela de Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zhang, Victor Y.. University of Washington; Estados Unidos
Fil: Neitz, Alexandra F.. University of Washington; Estados Unidos
Fil: Lee, Jeffrey. University of Washington; Estados Unidos
Fil: Takahashi, Joseph S.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Kim, Jeansok J.. University of Washington; Estados Unidos
Fil: de la Iglesia, Horacio Oscar. University of Washington; Estados Unidos
Materia
suprachiasmatic nuclei
fear
circadian entrainment
bmal-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/236959
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/236959
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainmentBussi, Ivana LedaBen Hamo, MiriamSalazar Leon, Luis E.Casiraghi, Leandro PabloZhang, Victor Y.Neitz, Alexandra F.Lee, JeffreyTakahashi, Joseph S.Kim, Jeansok J.de la Iglesia, Horacio Oscarsuprachiasmatic nucleifearcircadian entrainmentbmal-1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear-entrained clock, and provide a mechanistic insight into this clock.Fil: Bussi, Ivana Leda. University of Washington; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ben Hamo, Miriam. University of Washington; Estados UnidosFil: Salazar Leon, Luis E.. University of Washington; Estados UnidosFil: Casiraghi, Leandro Pablo. University of Washington; Estados Unidos. Universidad de San Andrés. Escuela de Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zhang, Victor Y.. University of Washington; Estados UnidosFil: Neitz, Alexandra F.. University of Washington; Estados UnidosFil: Lee, Jeffrey. University of Washington; Estados UnidosFil: Takahashi, Joseph S.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Kim, Jeansok J.. University of Washington; Estados UnidosFil: de la Iglesia, Horacio Oscar. University of Washington; Estados UnidosNational Academy of Sciences2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/236959Bussi, Ivana Leda; Ben Hamo, Miriam; Salazar Leon, Luis E.; Casiraghi, Leandro Pablo; Zhang, Victor Y.; et al.; The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 121; 13; 3-20240027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pnas.org/doi/10.1073/pnas.2316841121info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2316841121info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:07Zoai:ri.conicet.gov.ar:11336/236959instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:08.196CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
title The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
spellingShingle The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
Bussi, Ivana Leda
suprachiasmatic nuclei
fear
circadian entrainment
bmal-1
title_short The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
title_full The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
title_fullStr The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
title_full_unstemmed The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
title_sort The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment
dc.creator.none.fl_str_mv Bussi, Ivana Leda
Ben Hamo, Miriam
Salazar Leon, Luis E.
Casiraghi, Leandro Pablo
Zhang, Victor Y.
Neitz, Alexandra F.
Lee, Jeffrey
Takahashi, Joseph S.
Kim, Jeansok J.
de la Iglesia, Horacio Oscar
author Bussi, Ivana Leda
author_facet Bussi, Ivana Leda
Ben Hamo, Miriam
Salazar Leon, Luis E.
Casiraghi, Leandro Pablo
Zhang, Victor Y.
Neitz, Alexandra F.
Lee, Jeffrey
Takahashi, Joseph S.
Kim, Jeansok J.
de la Iglesia, Horacio Oscar
author_role author
author2 Ben Hamo, Miriam
Salazar Leon, Luis E.
Casiraghi, Leandro Pablo
Zhang, Victor Y.
Neitz, Alexandra F.
Lee, Jeffrey
Takahashi, Joseph S.
Kim, Jeansok J.
de la Iglesia, Horacio Oscar
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv suprachiasmatic nuclei
fear
circadian entrainment
bmal-1
topic suprachiasmatic nuclei
fear
circadian entrainment
bmal-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear-entrained clock, and provide a mechanistic insight into this clock.
Fil: Bussi, Ivana Leda. University of Washington; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ben Hamo, Miriam. University of Washington; Estados Unidos
Fil: Salazar Leon, Luis E.. University of Washington; Estados Unidos
Fil: Casiraghi, Leandro Pablo. University of Washington; Estados Unidos. Universidad de San Andrés. Escuela de Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zhang, Victor Y.. University of Washington; Estados Unidos
Fil: Neitz, Alexandra F.. University of Washington; Estados Unidos
Fil: Lee, Jeffrey. University of Washington; Estados Unidos
Fil: Takahashi, Joseph S.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Kim, Jeansok J.. University of Washington; Estados Unidos
Fil: de la Iglesia, Horacio Oscar. University of Washington; Estados Unidos
description We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear-entrained clock, and provide a mechanistic insight into this clock.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/236959
Bussi, Ivana Leda; Ben Hamo, Miriam; Salazar Leon, Luis E.; Casiraghi, Leandro Pablo; Zhang, Victor Y.; et al.; The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 121; 13; 3-2024
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/236959
identifier_str_mv Bussi, Ivana Leda; Ben Hamo, Miriam; Salazar Leon, Luis E.; Casiraghi, Leandro Pablo; Zhang, Victor Y.; et al.; The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 121; 13; 3-2024
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pnas.org/doi/10.1073/pnas.2316841121
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2316841121
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613600163921920
score 13.070432

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