Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge

Autores
de Laurentiis, Andrea; Correa, Fernando Gabriel; Fernández Solari, José Javier
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes.
Fil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Fernández Solari, José Javier. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ENDOCANNABINOID SYSTEM
HYPOTHALAMIC–PITUITARY–GONADAL AXIS
HYPOTHALAMUS
NEUROIMMUNENENDOCRINE AXIS
OXYTOCIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211218
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endocannabinoid system in the neuroendocrine response to LPS-induced immune challengede Laurentiis, AndreaCorrea, Fernando GabrielFernández Solari, José JavierENDOCANNABINOID SYSTEMHYPOTHALAMIC–PITUITARY–GONADAL AXISHYPOTHALAMUSNEUROIMMUNENENDOCRINE AXISOXYTOCINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes.Fil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Fernández Solari, José Javier. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaOxford University Press2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211218de Laurentiis, Andrea; Correa, Fernando Gabriel; Fernández Solari, José Javier; Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge; Oxford University Press; Journal of the Endocrine Society; 6; 10; 8-2022; 1-102472-1972CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvac120/6660711info:eu-repo/semantics/altIdentifier/doi/10.1210/jendso/bvac120info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:18Zoai:ri.conicet.gov.ar:11336/211218instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:18.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
title Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
spellingShingle Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
de Laurentiis, Andrea
ENDOCANNABINOID SYSTEM
HYPOTHALAMIC–PITUITARY–GONADAL AXIS
HYPOTHALAMUS
NEUROIMMUNENENDOCRINE AXIS
OXYTOCIN
title_short Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
title_full Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
title_fullStr Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
title_full_unstemmed Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
title_sort Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge
dc.creator.none.fl_str_mv de Laurentiis, Andrea
Correa, Fernando Gabriel
Fernández Solari, José Javier
author de Laurentiis, Andrea
author_facet de Laurentiis, Andrea
Correa, Fernando Gabriel
Fernández Solari, José Javier
author_role author
author2 Correa, Fernando Gabriel
Fernández Solari, José Javier
author2_role author
author
dc.subject.none.fl_str_mv ENDOCANNABINOID SYSTEM
HYPOTHALAMIC–PITUITARY–GONADAL AXIS
HYPOTHALAMUS
NEUROIMMUNENENDOCRINE AXIS
OXYTOCIN
topic ENDOCANNABINOID SYSTEM
HYPOTHALAMIC–PITUITARY–GONADAL AXIS
HYPOTHALAMUS
NEUROIMMUNENENDOCRINE AXIS
OXYTOCIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes.
Fil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Fernández Solari, José Javier. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211218
de Laurentiis, Andrea; Correa, Fernando Gabriel; Fernández Solari, José Javier; Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge; Oxford University Press; Journal of the Endocrine Society; 6; 10; 8-2022; 1-10
2472-1972
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211218
identifier_str_mv de Laurentiis, Andrea; Correa, Fernando Gabriel; Fernández Solari, José Javier; Endocannabinoid system in the neuroendocrine response to LPS-induced immune challenge; Oxford University Press; Journal of the Endocrine Society; 6; 10; 8-2022; 1-10
2472-1972
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvac120/6660711
info:eu-repo/semantics/altIdentifier/doi/10.1210/jendso/bvac120
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269214685003776
score 13.13397

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