Endocannabinoid system participates in the neuroendocrine control of homeostasis

Autores
de Laurentiis, Andrea; Fernández Solari, Jose Javier; Mohn, Claudia Ester; Zorrilla Zubilete, María Aurelia; Besuhli, Valeria
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The hypothalamo-neurohypophyseal system plays a role in homeostasis under a variety of stress conditions, including endotoxemia. Oxytocin (OXT) and vasopressin (VP) are important hormones synthesized by neurons in the hypothalamic paraventricular and supraoptic nuclei and released into different brain regions and from the neurohypophyseal terminals into the blood in response to many patho-physiological stimuli. However, the mechanism that controls OXT and VP secretion has not been fully elucidated. Nitric oxide (NO) is a known mediator that regulates the release of these hormones. The endocannabinoid system is a new intercellular system that modulates several neuroendocrine actions. Endocannabinoids (eCB) are released as retrograde messengers by many neurons, including hypothalamic magnocellular neurons and cannabinoid receptors are localized within these neurons, as well as in the anterior and posterior pituitary lobes, suggesting an eCB role in the production and release of OXT and VP. Lipopolysaccharide (LPS) injection is a model used as immune challenge. LPS causes a neuroendocrine response that is mediated by cytokines, tumor necrosis factor-α being one of them. We focused on NO and endocannabinoid system participation on OXT and VP production and secretion during basal and stress conditions and found that eCB affect basal OXT and VP secretion by acting differently at each level of the hypothalamo-neurohypophyseal system. After LPS, there is an increase in eCB synthesis that enhances OXT secretion
Fil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Fernández Solari, Jose Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mohn, Claudia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
Oxytocin
Vasopressin
Cannabinoid Receptors
Nitric Oxyde
Hypothalamus
Neurohypophysis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14492

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endocannabinoid system participates in the neuroendocrine control of homeostasisde Laurentiis, AndreaFernández Solari, Jose JavierMohn, Claudia EsterZorrilla Zubilete, María AureliaBesuhli, ValeriaOxytocinVasopressinCannabinoid ReceptorsNitric OxydeHypothalamusNeurohypophysishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The hypothalamo-neurohypophyseal system plays a role in homeostasis under a variety of stress conditions, including endotoxemia. Oxytocin (OXT) and vasopressin (VP) are important hormones synthesized by neurons in the hypothalamic paraventricular and supraoptic nuclei and released into different brain regions and from the neurohypophyseal terminals into the blood in response to many patho-physiological stimuli. However, the mechanism that controls OXT and VP secretion has not been fully elucidated. Nitric oxide (NO) is a known mediator that regulates the release of these hormones. The endocannabinoid system is a new intercellular system that modulates several neuroendocrine actions. Endocannabinoids (eCB) are released as retrograde messengers by many neurons, including hypothalamic magnocellular neurons and cannabinoid receptors are localized within these neurons, as well as in the anterior and posterior pituitary lobes, suggesting an eCB role in the production and release of OXT and VP. Lipopolysaccharide (LPS) injection is a model used as immune challenge. LPS causes a neuroendocrine response that is mediated by cytokines, tumor necrosis factor-α being one of them. We focused on NO and endocannabinoid system participation on OXT and VP production and secretion during basal and stress conditions and found that eCB affect basal OXT and VP secretion by acting differently at each level of the hypothalamo-neurohypophyseal system. After LPS, there is an increase in eCB synthesis that enhances OXT secretionFil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Fernández Solari, Jose Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Mohn, Claudia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaKarger2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14492de Laurentiis, Andrea; Fernández Solari, Jose Javier; Mohn, Claudia Ester; Zorrilla Zubilete, María Aurelia; Besuhli, Valeria; Endocannabinoid system participates in the neuroendocrine control of homeostasis; Karger; Neuroimmunomodulation.; 17; 3; 2-2010; 153-1561021-74011423-0216enginfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1159%2F000258711info:eu-repo/semantics/altIdentifier/doi/10.1159%2F000258711info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:28Zoai:ri.conicet.gov.ar:11336/14492instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:28.648CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endocannabinoid system participates in the neuroendocrine control of homeostasis
title Endocannabinoid system participates in the neuroendocrine control of homeostasis
spellingShingle Endocannabinoid system participates in the neuroendocrine control of homeostasis
de Laurentiis, Andrea
Oxytocin
Vasopressin
Cannabinoid Receptors
Nitric Oxyde
Hypothalamus
Neurohypophysis
title_short Endocannabinoid system participates in the neuroendocrine control of homeostasis
title_full Endocannabinoid system participates in the neuroendocrine control of homeostasis
title_fullStr Endocannabinoid system participates in the neuroendocrine control of homeostasis
title_full_unstemmed Endocannabinoid system participates in the neuroendocrine control of homeostasis
title_sort Endocannabinoid system participates in the neuroendocrine control of homeostasis
dc.creator.none.fl_str_mv de Laurentiis, Andrea
Fernández Solari, Jose Javier
Mohn, Claudia Ester
Zorrilla Zubilete, María Aurelia
Besuhli, Valeria
author de Laurentiis, Andrea
author_facet de Laurentiis, Andrea
Fernández Solari, Jose Javier
Mohn, Claudia Ester
Zorrilla Zubilete, María Aurelia
Besuhli, Valeria
author_role author
author2 Fernández Solari, Jose Javier
Mohn, Claudia Ester
Zorrilla Zubilete, María Aurelia
Besuhli, Valeria
author2_role author
author
author
author
dc.subject.none.fl_str_mv Oxytocin
Vasopressin
Cannabinoid Receptors
Nitric Oxyde
Hypothalamus
Neurohypophysis
topic Oxytocin
Vasopressin
Cannabinoid Receptors
Nitric Oxyde
Hypothalamus
Neurohypophysis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The hypothalamo-neurohypophyseal system plays a role in homeostasis under a variety of stress conditions, including endotoxemia. Oxytocin (OXT) and vasopressin (VP) are important hormones synthesized by neurons in the hypothalamic paraventricular and supraoptic nuclei and released into different brain regions and from the neurohypophyseal terminals into the blood in response to many patho-physiological stimuli. However, the mechanism that controls OXT and VP secretion has not been fully elucidated. Nitric oxide (NO) is a known mediator that regulates the release of these hormones. The endocannabinoid system is a new intercellular system that modulates several neuroendocrine actions. Endocannabinoids (eCB) are released as retrograde messengers by many neurons, including hypothalamic magnocellular neurons and cannabinoid receptors are localized within these neurons, as well as in the anterior and posterior pituitary lobes, suggesting an eCB role in the production and release of OXT and VP. Lipopolysaccharide (LPS) injection is a model used as immune challenge. LPS causes a neuroendocrine response that is mediated by cytokines, tumor necrosis factor-α being one of them. We focused on NO and endocannabinoid system participation on OXT and VP production and secretion during basal and stress conditions and found that eCB affect basal OXT and VP secretion by acting differently at each level of the hypothalamo-neurohypophyseal system. After LPS, there is an increase in eCB synthesis that enhances OXT secretion
Fil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Fernández Solari, Jose Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mohn, Claudia Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description The hypothalamo-neurohypophyseal system plays a role in homeostasis under a variety of stress conditions, including endotoxemia. Oxytocin (OXT) and vasopressin (VP) are important hormones synthesized by neurons in the hypothalamic paraventricular and supraoptic nuclei and released into different brain regions and from the neurohypophyseal terminals into the blood in response to many patho-physiological stimuli. However, the mechanism that controls OXT and VP secretion has not been fully elucidated. Nitric oxide (NO) is a known mediator that regulates the release of these hormones. The endocannabinoid system is a new intercellular system that modulates several neuroendocrine actions. Endocannabinoids (eCB) are released as retrograde messengers by many neurons, including hypothalamic magnocellular neurons and cannabinoid receptors are localized within these neurons, as well as in the anterior and posterior pituitary lobes, suggesting an eCB role in the production and release of OXT and VP. Lipopolysaccharide (LPS) injection is a model used as immune challenge. LPS causes a neuroendocrine response that is mediated by cytokines, tumor necrosis factor-α being one of them. We focused on NO and endocannabinoid system participation on OXT and VP production and secretion during basal and stress conditions and found that eCB affect basal OXT and VP secretion by acting differently at each level of the hypothalamo-neurohypophyseal system. After LPS, there is an increase in eCB synthesis that enhances OXT secretion
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14492
de Laurentiis, Andrea; Fernández Solari, Jose Javier; Mohn, Claudia Ester; Zorrilla Zubilete, María Aurelia; Besuhli, Valeria; Endocannabinoid system participates in the neuroendocrine control of homeostasis; Karger; Neuroimmunomodulation.; 17; 3; 2-2010; 153-156
1021-7401
1423-0216
url http://hdl.handle.net/11336/14492
identifier_str_mv de Laurentiis, Andrea; Fernández Solari, Jose Javier; Mohn, Claudia Ester; Zorrilla Zubilete, María Aurelia; Besuhli, Valeria; Endocannabinoid system participates in the neuroendocrine control of homeostasis; Karger; Neuroimmunomodulation.; 17; 3; 2-2010; 153-156
1021-7401
1423-0216
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1159%2F000258711
info:eu-repo/semantics/altIdentifier/doi/10.1159%2F000258711
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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