Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature

Autores
Ramborger, Mariano Enrique; Zorrilla Zubilete, María Aurelia; Acosta, Gabriela Beatriz
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Stress plays a fundamental role in the etiology and evolution of diseases and disorders both in the early stages of development and the adult life. Neuropsychiatric disorders such as depression, autism, ADHD and schizophrenia have a complex etiology, which is influenced by early experiences that affect the vulnerability of the individual.During early intrauterine and postnatal life, the developing organism undergoes complex physiological changes, and even small disturbances can have far-reaching consequences which can be observed even into adulthood. Currently, understanding the factors that may be affecting the organism during development is a challenge. Among the effects induced by Prenatal Stress we can mention a dysregulation of the HPA axis, an alteration of the circadian rhythm, a reduction of the hippocampal plasticity and the capacity of learning and memory among others.The effects of Prenatal Stress are widely studied in laboratory animals, but systematic research on human subjects is comparatively scarce. While studies in humans suffer from certain methodological limitations, they are currently the only way to explore some of the most complex, long-term interactions between antenatal stress and the behavioral and cognitive alterations of the offspring. This work aims to review studies about Prenatal Stress pertaining human subjects, and to explore some of the controversies arising on this field.
Fil: Ramborger, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Materia
Prenatal stress
human studies,
hypothalamic-pituitary-adrenal axis
neurodevelopment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87024
Acceder
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spelling Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literatureRamborger, Mariano EnriqueZorrilla Zubilete, María AureliaAcosta, Gabriela BeatrizPrenatal stresshuman studies,hypothalamic-pituitary-adrenal axisneurodevelopmenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Stress plays a fundamental role in the etiology and evolution of diseases and disorders both in the early stages of development and the adult life. Neuropsychiatric disorders such as depression, autism, ADHD and schizophrenia have a complex etiology, which is influenced by early experiences that affect the vulnerability of the individual.During early intrauterine and postnatal life, the developing organism undergoes complex physiological changes, and even small disturbances can have far-reaching consequences which can be observed even into adulthood. Currently, understanding the factors that may be affecting the organism during development is a challenge. Among the effects induced by Prenatal Stress we can mention a dysregulation of the HPA axis, an alteration of the circadian rhythm, a reduction of the hippocampal plasticity and the capacity of learning and memory among others.The effects of Prenatal Stress are widely studied in laboratory animals, but systematic research on human subjects is comparatively scarce. While studies in humans suffer from certain methodological limitations, they are currently the only way to explore some of the most complex, long-term interactions between antenatal stress and the behavioral and cognitive alterations of the offspring. This work aims to review studies about Prenatal Stress pertaining human subjects, and to explore some of the controversies arising on this field.Fil: Ramborger, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaOAT2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87024Ramborger, Mariano Enrique; Zorrilla Zubilete, María Aurelia; Acosta, Gabriela Beatriz; Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature; OAT; Pediatric Dimensions; 3; 1; 2-2018; 1-62397-950XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/prenatal-stress-and-its-effects-of-human-cognition-behavior-and-psychopathology-a-review-of-the-literature.phpinfo:eu-repo/semantics/altIdentifier/doi/10.15761/PD.1000159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:53Zoai:ri.conicet.gov.ar:11336/87024instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:54.22CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
title Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
spellingShingle Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
Ramborger, Mariano Enrique
Prenatal stress
human studies,
hypothalamic-pituitary-adrenal axis
neurodevelopment
title_short Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
title_full Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
title_fullStr Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
title_full_unstemmed Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
title_sort Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature
dc.creator.none.fl_str_mv Ramborger, Mariano Enrique
Zorrilla Zubilete, María Aurelia
Acosta, Gabriela Beatriz
author Ramborger, Mariano Enrique
author_facet Ramborger, Mariano Enrique
Zorrilla Zubilete, María Aurelia
Acosta, Gabriela Beatriz
author_role author
author2 Zorrilla Zubilete, María Aurelia
Acosta, Gabriela Beatriz
author2_role author
author
dc.subject.none.fl_str_mv Prenatal stress
human studies,
hypothalamic-pituitary-adrenal axis
neurodevelopment
topic Prenatal stress
human studies,
hypothalamic-pituitary-adrenal axis
neurodevelopment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Stress plays a fundamental role in the etiology and evolution of diseases and disorders both in the early stages of development and the adult life. Neuropsychiatric disorders such as depression, autism, ADHD and schizophrenia have a complex etiology, which is influenced by early experiences that affect the vulnerability of the individual.During early intrauterine and postnatal life, the developing organism undergoes complex physiological changes, and even small disturbances can have far-reaching consequences which can be observed even into adulthood. Currently, understanding the factors that may be affecting the organism during development is a challenge. Among the effects induced by Prenatal Stress we can mention a dysregulation of the HPA axis, an alteration of the circadian rhythm, a reduction of the hippocampal plasticity and the capacity of learning and memory among others.The effects of Prenatal Stress are widely studied in laboratory animals, but systematic research on human subjects is comparatively scarce. While studies in humans suffer from certain methodological limitations, they are currently the only way to explore some of the most complex, long-term interactions between antenatal stress and the behavioral and cognitive alterations of the offspring. This work aims to review studies about Prenatal Stress pertaining human subjects, and to explore some of the controversies arising on this field.
Fil: Ramborger, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
description Stress plays a fundamental role in the etiology and evolution of diseases and disorders both in the early stages of development and the adult life. Neuropsychiatric disorders such as depression, autism, ADHD and schizophrenia have a complex etiology, which is influenced by early experiences that affect the vulnerability of the individual.During early intrauterine and postnatal life, the developing organism undergoes complex physiological changes, and even small disturbances can have far-reaching consequences which can be observed even into adulthood. Currently, understanding the factors that may be affecting the organism during development is a challenge. Among the effects induced by Prenatal Stress we can mention a dysregulation of the HPA axis, an alteration of the circadian rhythm, a reduction of the hippocampal plasticity and the capacity of learning and memory among others.The effects of Prenatal Stress are widely studied in laboratory animals, but systematic research on human subjects is comparatively scarce. While studies in humans suffer from certain methodological limitations, they are currently the only way to explore some of the most complex, long-term interactions between antenatal stress and the behavioral and cognitive alterations of the offspring. This work aims to review studies about Prenatal Stress pertaining human subjects, and to explore some of the controversies arising on this field.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87024
Ramborger, Mariano Enrique; Zorrilla Zubilete, María Aurelia; Acosta, Gabriela Beatriz; Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature; OAT; Pediatric Dimensions; 3; 1; 2-2018; 1-6
2397-950X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87024
identifier_str_mv Ramborger, Mariano Enrique; Zorrilla Zubilete, María Aurelia; Acosta, Gabriela Beatriz; Prenatal Stress and its effects of human cognition, behavior and psychopathology: A review of the literature; OAT; Pediatric Dimensions; 3; 1; 2-2018; 1-6
2397-950X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.15761/PD.1000159
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv OAT
publisher.none.fl_str_mv OAT
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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